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Automatic control production process for medicinal barium sulfate

A production process, the technology of barium sulfate, applied in the field of automatic control production process of medicinal barium sulfate, can solve the problems of inability to accurately control the particle size range of barium sulfate, low pass rate of barium sulfate, etc., to achieve civilized production and improve operation Environment and labor intensity, the effect of optimizing product quality

Active Publication Date: 2017-07-21
青岛红蝶新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the above-mentioned defects that the pharmaceutical barium sulfate synthesis process existing in the prior art cannot accurately control the particle size range of barium sulfate, resulting in a low pass rate of barium sulfate synthesis, and to provide a pharmaceutical barium sulfate synthesis process. Advanced automatic control process, adopting automatic control production process, greatly improves the first pass rate of barium sulfate synthesis, ensures product quality and reduces cost

Method used

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  • Automatic control production process for medicinal barium sulfate
  • Automatic control production process for medicinal barium sulfate
  • Automatic control production process for medicinal barium sulfate

Examples

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preparation example Construction

[0034] figure 2 A process flow chart for the preparation of barium chloride / sodium sulfate is provided.

[0035] The preparation process of barium chloride solution: the central control system issues instructions, the cold water pump starts, and drinking water is added to the barium chloride tank. The liquid level gauge detects the water level in the barium chloride tank. When the water level reaches the set height, the agitator starts , the central control system issues an instruction, the feed valve is opened, the barium chloride is pumped into the barium chloride tank, the flow meter detects the flow rate of sodium sulfate, when the set flow rate is reached, the feed is stopped, the steam valve is opened for heating, and the barium chloride is stirred until it reaches the set flow rate. Dissolution, the temperature sensor detects the temperature of the liquid in the barium tank, the temperature is controlled within the set range, the solution is taken to measure the Baume ...

Embodiment 1

[0042] This embodiment provides a synthesis process of medicinal barium sulfate.

[0043] 1. Feed according to Table 1.

[0044] Table 1

[0045] Material name Specification Feed material / batch use Industrial Barium Chloride ≥98.0％ 3250kg Raw material for barium sulfate synthesis Industrial Sodium Sulfate ≥98.0％ 1900kg Raw material for barium sulfate synthesis

[0046] 2. Process flow:

[0047] (1) Preparation of barium chloride solution (abbreviated barium solution):

[0048] The central control system issues instructions, the cold water pump starts, and drinking water is added to the barium tank. The liquid level gauge detects the water level in the barium tank. When the water level reaches 2 / 3 of the barium tank, the agitator starts, and the central control system Instructions are issued, the feed valve is opened, the barium chloride is pumped into the barium chloride tank, and the flow meter detects the flow rate of sodium sulfate...

Embodiment 2

[0056] This embodiment provides a synthesis process of medicinal barium sulfate.

[0057] 1. Feeding is carried out as shown in Table 1 of Example 1.

[0058] 2. Process flow:

[0059] (1) Preparation of barium chloride solution (abbreviated barium solution):

[0060] The central control system issues instructions, the cold water pump starts, and drinking water is added to the barium tank. The liquid level gauge detects the water level in the barium tank. When the water level reaches 2 / 3 of the barium tank, the agitator starts, and the central control system Instructions are issued, the feed valve is opened, the barium chloride is pumped into the barium chloride tank, and the flow meter detects the flow rate of sodium sulfate. When the set flow rate is reached, the feed is stopped, the steam valve is opened for heating, and the barium chloride is stirred until the barium chloride is dissolved, and the sample is measured. The Baume degree of the solution, the central control ...

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Abstract

The invention relates to the technical field of barium sulfate synthesis, in particular to an automatic control production process for medicinal barium sulfate. The process includes: a central control system sends a production instruction to start a cold water pump for pumping drinking water into a chemical combination tank; when the water level reaches a 1 / 7-1 / 4 position of the chemical combination tank, a stirrer starts, and a steam valve starts to heat; when the water temperature reaches 60-80 DEG C, a feeding valve starts, and barium chloride solution and sodium sulfate solution equal in quantity are pumped into the chemical combination tank from a barium solution storage tank and a nitrate solution storage tank at the same time to realize chemical combination; when a set flow rate is achieved, feeding stops, chemical combination is finished, sampling for detecting particle size and reaction endpoints is performed to guarantee slight excessiveness of sulfate radicals, the central control system sends an instruction, a bottom gate of the chemical combination tank opens, and an automatic delivery device delivers materials to a pressure filter. By adoption of the automatic control production process, one-time qualification rate of barium sulfate synthesis is greatly increased, product quality is guaranteed, and cost is reduced.

Description

technical field [0001] The invention relates to the technical field of barium sulfate synthesis, in particular to an automatic control production process of medicinal barium sulfate. Background technique [0002] Barium sulfate is mainly used as a gastrointestinal contrast agent in medicine. According to the requirements of the Pharmacopoeia quality standards, the viscosity of medicinal barium sulfate should not exceed 0.150Pa.s, and the sedimentation volume ratio should be higher than 0.90. Size is related to distribution. In fact, the viscosity is directly proportional to the sedimentation volume ratio, and the higher the viscosity, the higher the sedimentation volume ratio, that is, it is not easy to settle, and the Pharmacopoeia's requirements for these two indicators are opposite to each other, that is, low viscosity and high sedimentation volume ratio are required. This requires that the synthetic particle size of barium sulfate should be controlled very accurately w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01F11/46A61K49/04
CPCY02P20/129C01F11/462A61K49/0404C01P2004/61C01P2004/62C01P2006/22C01P2006/82C01P2006/90
Inventor 刘志龙贾道峰
Owner 青岛红蝶新材料有限公司
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