Micro-fluidic chip based on 3D printing and emulsion production device including micro-fluidic chip

Abstract

The invention provides a micro-fluidic chip based on 3D printing. The micro-fluidic chip comprises a micro-drop module, an emulsion module, a dispersion phase module and a continuous phase module, wherein a drop production channel is formed in the micro-drop module; an emulsion channel communicated with the drop production channel is formed in the emulsion module; a dispersion phase channel is formed in the dispersion phase module and is communicated with the drop production channel and the emulsion channel, and center axes of the dispersion phase channel, the drop production channel and the emulsion channel coincide with one another; the continuous phase module is located on one side of a center axis, and a continuous phase channel is formed in the continuous phase module; and the continuous phase channel and the dispersion phase channel form a confluence part in the micro-fluidic chip, and the confluence part is located between a dispersion phase channel inlet and the drop production channel. The invention further provides an emulsion production device. The micro-fluidic chip for preparing an emulsion and the emulsion production device including the micro-fluidic chip have simple structures, are detachable, convenient to prepare and assemble and easy to maintain, the produced micro-drops are uniform and good in dispersity, and meanwhile, the micro-drops with relatively small sizes can be produced.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a microfluidic chip based on 3D printing and an emulsion generating device including the chip. Background technique [0002] Emulsion is a relatively stable emulsified liquid system formed by uniformly dispersing one liquid in the form of fine droplets in another immiscible liquid. Among them, one phase dispersed in the form of droplets is called the dispersed phase (or internal phase, discontinuous phase), and the other phase is called the continuous phase (or external phase, dispersion medium). Usually one of the phases is water or an aqueous solution, commonly known as the water phase; the other phase is an organic phase immiscible with water, commonly known as the oil phase. The external phase is water and the internal phase is oil, which is oil-in-water emulsion (O / W); otherwise, it is water-in-oil emulsion (W / O). Emulsion is widely used in materials, chemical indust...

AI Technical Summary

Problems solved by technology

[0005] However, the existing microfluidic micro-droplet preparation devices and methods, specifically, such as Figure 1-2 As shown, the micro-droplet production device disclosed in prior art 1 (CN103386333A) is a planar microfluidic chip, the preparation process is complicated, and the structure is integrally formed and cannot be disassembled. Once a part is blocked or damaged, the whole chip won't work

Additionally, if image 3 As shown, the droplet production device disclosed in prior art 2 (CN 102300564A) has complex preparation and assembly, and the size of the produced droplets is preferably at the millimeter level, so that it cannot fully satisfy the use of microdroplets in various size ranges. need

[0006] At present, commonly used microfluidic chip preparation techniques, such as soft lithography, glass tube assembly, hot-pressed polymer molding, etc., are limited by the complicated preparation process and high preparation cost, which restricts the development of microfluidic microchips. Development and Promotion of Droplet Technology

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