Multimodal imaging system and imaging method thereof

Abstract

The invention provides a multimode imaging system and an imaging method thereof. The multimode imaging system comprises a first laser device, a second laser device, a delay device, an imaging probe, an ultrasonic transceiving instrument, a fluorescent detector and a data acquisition and processing module. The first laser device generates a first light signal and a light source triggering signal, and the light source triggering signal is transmitted to the second laser device through the delay device to generate a second light signal. The first light signal and the second light signal are emitted to detected tissue through the imaging probe, and a first photoacoustic signal, a first fluorescent signal, a second photoacoustic signal and a second fluorescent signal are excited separately. The first laser device further generates an ultrasonic triggering signal, and the ultrasonic triggering signal is transmitted to the ultrasonic transceiving instrument through the delay device to generate a second ultrasonic signal. The signals are all received by the imaging probe and transmitted to the data acquisition and processing module to obtain image information. The multimode imaging system can simultaneously obtain photoacoustic, ultrasonic, fluorescent and photoacoustic spectrum imaging information of the detected tissue.

Description

technical field [0001] The invention relates to the technical field of biomedical imaging, in particular to a multimodal imaging system and an imaging method thereof. Background technique [0002] Photoacoustic imaging technology is a non-invasive biomedical imaging technology that combines the advantages of optical and ultrasonic imaging. It has the advantages of large depth and high resolution imaging for obtaining information such as the morphology, structure and distribution of lesions. However, this imaging technology mainly focuses on structural For functional imaging, it is difficult to obtain functional quantitative data, and it is also impossible to obtain the content of a specific component in the tissue. Fluorescence imaging technology can detect the composition of different molecules through fluorescent endoscopic probes, and can also indicate the status of tumors or lesions such as atherosclerotic plaques in blood vessels. However, fluorescent endoscopic probes...

AI Technical Summary

Problems solved by technology

[0003] However, the photoacoustic-fluorescence imaging system in the prior art has some shortcomings, for example, it can only detect the photoacoustic-fluorescence signal under a certain wavelength of the laser signal, so that the accuracy of the detection result is not high, or it can be Detect photoacoustic-fluorescence signals under laser signals of different wavelengths, but it takes a lot of time to switch between different wavelengths, which causes the detection process to take too long and reduces the detection efficiency when more samples are detected

The photoacoustic-fluorescence imaging system in the prior art cannot perform dynamic real-time measurement and analysis of information such as the structure, distribution and composition of biological tissues

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