Compound Chinese traditional medicine ointment containing ozonated radix arnebiae oil and preparation method thereof

A technology of comfrey trioxide and compound traditional Chinese medicine, which is applied to medical preparations containing active ingredients, medical preparations without active ingredients, ointment delivery, etc., and can solve the problems of unspecified active ingredient content, inevitable loss of active ingredients, The low efficiency of the extraction method achieves the effects of avoiding toxic and side effects, clear compound ingredients, and good transdermal performance

Inactive Publication Date: 2017-08-11
广东祈福医院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Chinese patent CN106177452 discloses the preparation and application of compound comfrey ozone oil. It obtains compound comfrey oil by pressing, and obtains trioxide comfrey oil after passing through ozone. Active ingredient content
The obtained oily liniment has low viscosity, which is not conducive to application and short residence time on the affected area, which will cause problems such as uneven application, low drug efficacy, and poor patient compliance; the loss is large during use, and it is easy to contaminate the bottle wall
In addition, the Chinese herbal medicines used need to go through multiple processing steps of frying, crushing, fermentation, steaming, pressing, filtering, dehydration, and decolorization. The process is too cumbersome and the active ingredients are inevitably lost during the preparation process.

Method used

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  • Compound Chinese traditional medicine ointment containing ozonated radix arnebiae oil and preparation method thereof
  • Compound Chinese traditional medicine ointment containing ozonated radix arnebiae oil and preparation method thereof
  • Compound Chinese traditional medicine ointment containing ozonated radix arnebiae oil and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Embodiment 1: Angelica dahurica micronization

[0046] The preparation method is as follows: put the washed Angelica dahurica in a hot air circulation oven, set the drying temperature at 60°C, dry for 1 hour, crush it with a traditional Chinese medicine powder machine, pass it through an 80-mesh sieve, and crush the powder of Angelica dahurica with a jet mill, and the crushing air pressure is 0.3 mpa, collecting micronized Angelica dahurica. The particle size distribution of the micronized Angelica dahurica was measured by a laser particle size analyzer, and the results are shown in Table 1.

[0047] Table 1 Particle size distribution of micronized Angelica dahurica

[0048]

Embodiment 2

[0050] A kind of preparation step of the compound traditional Chinese medicine ointment containing comfrey oil trioxide:

[0051] (1) Add comfrey into olive oil at a weight ratio of 2:5, soak completely and filter to obtain comfrey oil, measure 500 g and inject 500 mcg of ozone to obtain comfrey trioxide oil, and set aside;

[0052] (2) Weigh 27.5g of beeswax, 57.5g of vaseline, and 2.5g of phospholipid, heat it to 60°C, and emulsify it with a high-speed shear homogenizer at 8000rpm for 15min to obtain an ointment base;

[0053] (3) Add 5 g of eugenol and 0.25 g of peppermint oil into the above-mentioned ointment base, and homogeneously emulsify at 60° C. (high-speed shear homogenizer at 10,000 rpm for 10 min);

[0054] (4) Weigh 7.5 g of the micronized Angelica dahurica of Example 1 and mix it with 2 g of titanium dioxide evenly, then add it to the ointment of the previous step, and homogeneously emulsify at 60°C (high-speed shear homogenizer 10000rpm homogeneously emulsify f...

Embodiment 3

[0057] A kind of preparation step of the compound traditional Chinese medicine ointment containing comfrey oil trioxide:

[0058] (1) measure the comfrey oil 500g of embodiment 2 and pass into the ozone of 1000mcg, obtain comfrey oil trioxide, standby;

[0059] (2) Weigh 27.5g of beeswax, 57.5g of vaseline, and 2.5g of phospholipid, heat it to 60°C, and emulsify it with a high-speed shear homogenizer at 6000rpm for 25min to obtain an ointment base;

[0060] (3) Add 5 g of eugenol and 0.25 g of peppermint oil into the above-mentioned ointment base, and homogeneously emulsify at 40°C (high-speed shear homogenizer at 10,000 rpm for 5 min);

[0061] (4) Weigh 7.5 g of the micronized Angelica dahurica of Example 1 and mix it with 2 g of titanium dioxide evenly, then add it to the ointment of the previous step, and homogeneously emulsify at 40°C (high-speed shear homogenizer 10000rpm homogeneously emulsify for 5min);

[0062] (5) Add 500 g of the spare comfrey oil trioxide mentione...

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Abstract

The invention discloses a compound Chinese traditional medicine ointment containing ozonated radix arnebiae oil and a preparation method thereof. The ointment is prepared from, by weight, 20 parts of ozonated radix arnebiae oil, 0-3 parts of radix angelicae, 0.2 part of eugenol, 1.1 parts of beeswax, 2.3 parts of vaseline, 0.1 part of phospholipid, 0.01 part of peppermint oil and 0.08 part of opacifying agent. The ointment obtained by adopting the preparation method can overcome the shortcomings of existing dosage forms, the dosing convenience and the effectiveness of the compound of the ozonated Chinese herbal compound are improved, and meanwhile a good clinical effect can be achieved. Clinically, radix arnebiae oil ointments different in ozonization degree are selected according to indications and can be used for killing bacteria and pathogenic microorganisms. The ointment is externally applied and is used for treating neurodermatitis, trophic ulcer, wound surfaces, burn, mosquito bite, beautifying the skin and dispelling freckles. Proliferation of granulation tissues and epithelial cells at diseased parts can be accelerated, and the ointment can be used for treating various (oral, genital, rectal) mucosal diseases.

Description

technical field [0001] The invention belongs to the field of compound traditional Chinese medicines, in particular to a compound traditional Chinese medicine ointment containing comfrey oil trioxide and a preparation method thereof. Background technique [0002] The chemical formula for ozone is O 3 , has a pungent smell, also known as ozone. Ozone is a natural oxidant. High-purity O3 has the effect of killing various bacteria, viruses, fungi, etc., and has the characteristics of "green" sterilization. Source: The history, current situation and future of ozone therapy. At present, in Europe, ozone is mainly used in the treatment of lumbar disc herniation and bone and joint diseases, the treatment of trauma and refractory ulcers (such as diabetic foot), the adjuvant treatment of cancer, and the anti-freedom therapy. Based on the treatment of diseases such as anti-aging, stroke and viral hepatitis, its clinical efficacy has been fully affirmed. [0003] Comfrey, scientific ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61K9/06A61K47/24A61K47/06A61K47/44A61K47/10A61P17/02A61P31/10A61P31/04A61P31/00A61P17/00A61P25/00A61P1/02A61P15/00A61P1/00A61K33/00A61K31/085A61K35/644
Inventor 彭磷基
Owner 广东祈福医院有限公司
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