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A kind of ivermectin long-acting transdermal absorption agent and preparation method thereof

The technology of a transdermal absorbent and ivermectin, which is applied in the field of pharmaceutical preparations, can solve the problems of short duration of effect and need to be repeated multiple times of medication, and achieve the effects of long effective time and convenient use.

Active Publication Date: 2019-11-22
HENAN AGRICULTURAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of short duration of action of transdermal and oral drugs currently on the market and the need for repeated medications, the present invention screens a variety of Solvent system, with high-efficiency penetration enhancer azone, absolute ethanol, N,N-dimethylformamide and α-pyrrolidone as excipients, the best solvent combination, developed by transdermal absorption theory and production technology The ivermectin long-acting transdermal absorber is easy to use, safe and has a long effective time, and can effectively kill animal endoparasites and ectoparasites

Method used

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  • A kind of ivermectin long-acting transdermal absorption agent and preparation method thereof
  • A kind of ivermectin long-acting transdermal absorption agent and preparation method thereof
  • A kind of ivermectin long-acting transdermal absorption agent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] The invention provides a long-acting transdermal absorbent for ivermectin. Each liter of the long-acting transdermal absorbent for ivermectin comprises the following components: ivermectin raw material: 2-20 g; absolute ethanol: 100 g ~200 mL; Azone 10~30 mL; α-Pyrrolidone 100~400 mL; N,N-Dimethylformamide: Add to 1L.

[0021] The preparation method of described ivermectin transdermal absorption agent, comprises the following steps:

[0022] (1) Weigh the ivermectin raw material and absolute ethanol according to the above ratio, dissolve the ivermectin raw material in absolute ethanol, and stir until completely dissolved to obtain a mixed solution a;

[0023] (2) First take N,N-dimethylformamide with a volume fraction of 20-30% of the total volume, and then add the formula amount of azone to obtain the mixed solution b;

[0024] (3) Add the mixed solution b to the mixed solution a, and stir evenly to obtain the mixed solution c;

[0025] (4) Add the formulated amount ...

Embodiment 2

[0028] The invention provides an ivermectin long-acting transdermal absorbent, each liter of the ivermectin long-acting transdermal absorbent comprises the following components: 15g; absolute ethanol: 180 mL; azone: 20 mL; - Pyrrolidone 300 mL; N,N-Dimethylformamide: make up to 1 L.

[0029] The preparation method of this embodiment is the same as that of Example 1.

Embodiment 3

[0031] The invention provides a long-acting transdermal absorbent for ivermectin. Each liter of the long-acting transdermal absorbent for ivermectin comprises the following components: ivermectin raw material: 2g; absolute ethanol: 120 mL; Azone 30 mL; α-pyrrolidone 200 mL; N,N-dimethylformamide: add to 1L.

[0032] The preparation method of this embodiment is the same as that of Example 1.

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Abstract

The invention provides an ivermectin long-acting permeable absorber. Each liter of ivermectin long-acting permeable absorber is prepared from the following components: 2-20g of an ivermectin crude drug, 100-200mL of absolute ethyl alcohol, 10-30mL of azone, 100-400mL of alpha-pyrrolidone and N,N-dimethyl formamide added to 1L. According to the physicochemical property that ivermectin is not dissolvable in water and easily dissolvable in an organic solvent, optimal solvent combination is carried out by adopting high-efficiency penetration enhancer azone, absolute ethyl alcohol, N,N-dimethyl formamide and alpha-pyrrolidone as excipients through screening multiple solvent systems, and the ivermectin long-acting permeable absorber is prepared by adopting a transdermal absorption theory and a production technology. The product has the characteristics of being convenient to use, safe and long in effective time, and parasites inside and outside animals can be effectively killed.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to an ivermectin long-acting transdermal absorbent and a preparation method thereof. Background technique [0002] Parasitic diseases are common and serious diseases in the breeding industry. Because parasites take the nutrients needed by livestock and poultry, they secrete harmful substances, causing animals to become thin, anemic, weak, reduce production performance, and even die. Ivermectin is a new type of broad-spectrum, high-efficiency, and low-toxic antibiotic antiparasitic drug, which has a good killing effect on most internal and external parasites. Currently widely used in animal ticks, mites, mosquitoes, nematodes and other internal and external parasitic diseases. Today, it has been made into various preparations in many countries, such as tablets, injections, powders, capsules, oral liquids, transdermal agents, ointments, liniments, etc. [0003] A...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7048A61K47/22A61P33/02A61P33/14A61P33/10
CPCA61K9/0014A61K9/08A61K31/7048A61K47/22
Inventor 宁长申刘营营岳治光王学良张素梅菅复春宋耀民张龙现王荣军
Owner HENAN AGRICULTURAL UNIVERSITY