An amphoteric carboxymethyl chitosan guanidine salt derivative and a preparing method thereof

A technology of carboxymethyl chitosan and its derivatives, which is applied in the field of amphoteric carboxymethyl chitosan guanidinium salt derivatives and its preparation, can solve problems affecting application, long reaction time, complicated process, etc., and achieve improved water solubility , The preparation method is simple and the price is cheap

Inactive Publication Date: 2017-08-15
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing chitosan guanidinylation modification methods all need to be carried out in an acidic environment, and there are many shortcomings such as complicated process and long reaction time, which affect its further application to a certain extent.

Method used

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  • An amphoteric carboxymethyl chitosan guanidine salt derivative and a preparing method thereof
  • An amphoteric carboxymethyl chitosan guanidine salt derivative and a preparing method thereof
  • An amphoteric carboxymethyl chitosan guanidine salt derivative and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Preparation of amphoteric carboxymethyl chitosan guanidinium salt derivatives

[0044] 100 mg of carboxymethyl chitosan was added to 100 ml of deionized water, and mechanically stirred for 30 min under a water bath condition of 25° C. to obtain a carboxymethyl chitosan aqueous solution with a concentration of 1 mg / ml;

[0045] According to the molar ratio of thiourea trioxide and carboxymethyl chitosan is the ratio of 10:1, under the condition of 25 ℃, thiourea trioxide is slowly added in the described carboxymethyl chitosan aqueous solution in 30min, Keep the reaction temperature in the reactor at 25°C, and react for 60 minutes to obtain the second mixed solution;

[0046] Filter the second mixed solution and put it into a dialysis bag, tie both ends of the dialysis bag tightly and put it into deionized water for dialysis treatment, change the water every four hours, and put the dialysate into the dialysis bag after changing the water eight times. Freeze in a refriger...

Embodiment 2 to 8

[0049] Except the contents shown in Table 1, amphoteric carboxymethyl chitosan guanidinium salt derivatives were prepared in the same manner as in Example 1.

[0050] Raw material consumption and preparation process parameters in the preparation of amphoteric carboxymethyl chitosan guanidinium salt derivative in the embodiment 1-8 of table 1

[0051]

[0052] Sample elemental analysis result and guanidino substitution degree in table 2 raw material, embodiment 1-8

[0053]

Embodiment 9

[0055] Application of Amphoteric Carboxymethyl Chitosan Guanidine Derivatives in Antibacterial Properties

[0056] The test is carried out according to the plate coating method in the 2002 edition of the "Disinfection Technical Specifications" issued by the Ministry of Health. The culture medium is mixed evenly according to the ratio of 1:9, and then poured into the petri dish while it is hot. The culture dish needs about 20ml of culture medium solution. cultured in an incubator for 36 hours.

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Abstract

An amphoteric carboxymethyl chitosan guanidine salt derivative is provided. The structure formula of the derivative is shown in the specification, wherein n and x are natural numbers, the n is the number of repeated carboxymethyl chitosan structure units, the x is the number of repeated guanidyl substitute structure units, the n is 10-107, and the x is 1-107. According to the derivative, guanidyl having higher helectropositivity is introduced to a molecular chain of the carboxymethyl chitosan, thus endowing the chitosan with better bacteriostatic and antibacterial effects. A preparing method of the derivative is simple. The derivative is suitable for environments with different charges, and the using pH range of the derivative is wider.

Description

technical field [0001] The invention relates to the field of chitosan, in particular to an amphoteric carboxymethyl chitosan guanidinium salt derivative and a preparation method thereof. Background technique [0002] Among the natural organic compounds existing on the earth, the largest amount is cellulose, followed by chitin (the structural formula is shown in formula 1); meanwhile, chitin is also the largest renewable nitrogen-containing natural organic compound on the earth except protein [ Jiang Tingda, Chitosan, 2nd edition 2006]. Chitosan (Chitosan) is the product of deacetylation of chitin. Its structural formula is shown in formula 2. It is a natural alkaline polysaccharide with excellent biocompatibility and biodegradability, and it is easy to make various derivatives. thing. Because of its extremely rich sources, it can be dissolved in hydrochloric acid, acetic acid and other organic acids, and has been widely used in industrial and medical fields. Especially fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/003
Inventor 牛忠伟蒋士冬吴曼孙彦祥
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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