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Method of using naphthylacetonitrile to synthesize methoxy naphthylacetonitrile

A technology of methoxynaphthaleneacetonitrile and naphthaleneacetonitrile, which is applied in chemical instruments and methods, preparation of organic compounds, preparation of carboxylic acid nitriles, etc., can solve problems such as failure, low yield, environmental pollution, etc., and reduce emissions , short reaction time, weaken the effect of pollution

Inactive Publication Date: 2017-08-18
枣阳市残联福利生物化工厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And when synthesizing agomelatine, methoxy naphthalene acetonitrile is key intermediate, and in the prior art, present methoxy naphthalene acetonitrile productive rate is not high, easily occurs unsuccessful accident, a large amount of pollutants emission, the pollution to the environment is also becoming more and more serious, for this reason, we have proposed a kind of method utilizing naphthalene acetonitrile to synthesize methoxy naphthalene acetonitrile

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The present invention proposes a kind of method utilizing naphthaleneacetonitrile synthetic methoxynaphthaleneacetonitrile, comprises the steps:

[0023] (1), choose methoxyl group, naphthaleneacetonitrile and catalyst as raw material, and make methoxyl group and naphthaleneacetonitrile carry out sealed preservation under the environment of 35 degrees centigrade;

[0024] (2), select the container that has been sterilized and dried as the reaction device, and pass into the solvent in the container,

[0025] (3), move the methoxy group and naphthaleneacetonitrile in (1) into the container described in (2), and place it under the environment of 45 degrees Celsius, and feed oxygen into it to generate oxidation reaction, thereby obtaining white a mixture of crystals and the first solution;

[0026] (4), using a filter device to filter the white crystals and the first solution, and collect the filtrate, thereby removing the white crystals in the mixture;

[0027] (5), pass...

Embodiment 2

[0038] The present invention proposes a kind of method utilizing naphthaleneacetonitrile synthetic methoxynaphthaleneacetonitrile, comprises the steps:

[0039] (1), select methoxyl group, naphthaleneacetonitrile and catalyzer as raw material, and make methoxyl group and naphthaleneacetonitrile carry out sealed preservation under the environment of 38 degrees centigrade;

[0040] (2), select the container that has been sterilized and dried as the reaction device, and pass into the solvent in the container,

[0041] (3), move the methoxy group and naphthalene acetonitrile in (1) into the container described in (2), and place it under the environment of 50 degrees Celsius, and feed oxygen into it to generate oxidation reaction, thereby obtaining white a mixture of crystals and the first solution;

[0042] (4), using a filter device to filter the white crystals and the first solution, and collect the filtrate, thereby removing the white crystals in the mixture;

[0043] (5), pa...

Embodiment 3

[0054] The present invention proposes a kind of method utilizing naphthaleneacetonitrile synthetic methoxynaphthaleneacetonitrile, comprises the steps:

[0055] (1), select methoxyl group, naphthaleneacetonitrile and catalyzer as raw material, and make methoxyl group and naphthaleneacetonitrile carry out sealed preservation under the environment of 42 degrees centigrade;

[0056](2), select the container that has been sterilized and dried as the reaction device, and pass into the solvent in the container,

[0057] (3), move the methoxy group and naphthaleneacetonitrile in (1) into the container described in (2), and place it under the environment of 55 degrees Celsius, and feed oxygen into it to generate oxidation reaction, thereby obtaining white a mixture of crystals and the first solution;

[0058] (4), using a filter device to filter the white crystals and the first solution, and collect the filtrate, thereby removing the white crystals in the mixture;

[0059] (5), feed...

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PUM

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Abstract

The invention discloses a method of using naphthylacetonitrile to synthesize methoxy naphthylacetonitrile; the method comprises the steps of introducing a solvent into a container, transferring methoxy and naphthylacetonitrile into the container, placing the container in an environment at 45-60 DEG C, introducing oxygen the container to allow oxidation reaction so as to obtain mixture of white crystal and first solvent, using a filter to filter the white crystal and first solution, collecting filtrate, removing the white crystal in the mixture, introducing a catalyst again into the container holding the first solution so as to obtain crude methoxy naphthylacetonitrile, dissolving the crude methoxy naphthylacetonitrile in an organic solvent, reacting in the environment at 45-60 DEG C until completion, adding water again, stirring, cooling the reacted mixture, filtering, and crystallizing precipitate with alcoholate to obtain methoxy naphthylacetonitrile. The synthetic process used herein is simple and reliable, and pollutant emission can be effectively decreased.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a method for synthesizing methoxynaphthaleneacetonitrile by using naphthaleneacetonitrile. Background technique [0002] Agomelatine is the first antidepressant drug targeting melatonin hormone developed by French Servier company, and it is also used as MT1 and MT2 melatonin receptor agonist and 5-HT2 at the same time. Antagonists of the first antidepressants. Compared with traditional selective serotonin reuptake inhibitor (SSRI) and serotonin norepinephrine reuptake inhibitor (SNRI) antidepressants, it has superior antidepressant efficacy and enables severe disorders in depressed patients The biorhythm of the patients returned to normal, and in patients with severe depression, the antidepressant efficacy of agomelatine was better than that of SSRI fluoxetine. And when synthesizing agomelatine, methoxy naphthalene acetonitrile is key intermediate, and in the prior a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C253/30C07C253/00C07C255/54
CPCC07C253/30C07C253/00
Inventor 曹亮
Owner 枣阳市残联福利生物化工厂