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Non-enzymatic debriding agent and method of use thereof

A debridement, non-enzymatic technology, applied in the field of wound care, which can solve the problems of requiring prescriptions, high treatment costs, inflammation and discomfort, etc.

Active Publication Date: 2017-08-29
CMC CONSULTING BOSTON INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages of enzymatic debridement include: high cost of treatment ($250 per tube, $4000 per treatment), it requires a prescription, and enzymatic debridement causes inflammation and considerable discomfort

Method used

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  • Non-enzymatic debriding agent and method of use thereof
  • Non-enzymatic debriding agent and method of use thereof
  • Non-enzymatic debriding agent and method of use thereof

Examples

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Embodiment Construction

[0023]It is conceivable that there will be at least three different embodiments (product formulations) of the subject non-enzymatic debridement agent. One is the dressing. Dressing choices will be moderately to highly absorbent materials such as foam, hydrocolloid dressings, or biocomposite dressings. Although dressings are used to wick dissolved eschar material, it is conceivable that negative pressure wound therapy (NPWT) could be an alternative method of removing eschar material. A second embodiment is an ointment. For example, ointments may contain thickening agents such as white petrolatum USP, xanthan gum, or polyethylene glycol. The formulations may be combined with antibiotic or antimicrobial dressings, aqueous solutions, gels, hydrogels or ointments. Since non-enzymatic wound debriding agents denature collagen, it would be contrary to collagen dressings. A third embodiment of the formulation is a liquid rinse under pressure to aid dissolution of the eschar materia...

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PUM

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Abstract

A non-enzymatic debridement agent that is less expensive, less cytotoxic, and more effective than enzymatic and sharp surgical debridement of eschar material. The non-enzymatic debridement agent is based on a formulation of detergent (10) with a high critical micelle concentration and a denaturing agent (12) along with an optimized buffer that dissolves eschar material in under one week. The buffer or ointment may contain an optimized pH, salt concentration, reducing agent, and other components that aid in the debridement of eschar material from chronic wounds and burn wounds. The non-enzymatic debridement agent can be formulated as an ointment, liquid rinse under pressure, and / or as a combination product with an advanced wound dressing that can act as a sink to remove the solubilized eschar material from the surface of the wound to assist in the debridment and proper healing of wounds.

Description

field of invention [0001] The present invention relates to the fields of wound care, wound repair and tissue regeneration. Such formulations may have additional dermatological and medical applications. The main indications are non-enzymatic debridement of chronic wounds, acute wounds and burn wounds. However, secondary applications include reconstructive surgery and tissue remodeling. Background of the invention [0002] Chronic wounds often have necrotic tissue (hard black eschar and yellow slough) that needs to be removed before proper wound healing can begin. Currently widely used methods include enzymatic debridement and sharp surgical debridement. There are other methods used for debridement, including the use of fly maggots and mechanical debridement (water under pressure, containing B 2 o 3 glass-based biodegradable composition, ultrasound and laser). Although the latter methods have some technical advantages, they are rarely used in the field and thus will not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00C11D1/00C11D1/02C11D1/66A61K38/08
CPCA61K38/08A61K38/10A61K9/06A61K31/17A61K9/0019A61K47/36A61K45/06A61K31/155A61K31/7016A61P17/00A61P17/02A61P31/04A61P41/00A61K2300/00A61K47/02A61K47/20A61K47/26A61K47/42
Inventor M.桑德斯
Owner CMC CONSULTING BOSTON INC