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Polysiloxane block copolymer grafted with cysteine ​​and its preparation method and application

A polysiloxane block and cysteine ​​technology, applied in chemical instruments and methods, other chemical processes, etc., can solve problems such as limitations

Active Publication Date: 2020-04-07
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zwitterionic polymers have shown excellent performance in the study of anti-protein adsorption by forming a "hydration layer" with a barrier effect. However, due to their good water solubility, zwitterionic polymers are often difficult to absorb in aqueous solutions. Hydrophobic surfaces that are susceptible to protein contamination aggregate to form an effective stable adsorption layer, which is limited in many applications where resistance to protein adsorption is required

Method used

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  • Polysiloxane block copolymer grafted with cysteine ​​and its preparation method and application
  • Polysiloxane block copolymer grafted with cysteine ​​and its preparation method and application
  • Polysiloxane block copolymer grafted with cysteine ​​and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0054] Preparation of polydimethylsiloxane-polysiloxane grafted cysteine ​​block copolymer: the block length ratio is PDMS:PDMS-g-Cys=1:4, the PDMS block length is 1kDa, and the PDMS- The g-Cys block is 4 kDa long. In the PDMS-g-Cys block, the proportion of the chain segments grafted with cysteine ​​groups to the total number of segments (grafting ratio) is 1 / 2. The preparation process is as figure 1 As shown, the specific steps are as follows:

[0055] (1) In a reaction flask equipped with a magnetic stir bar, add 2.5g D 3 , and then seal it with a silica gel stopper, vacuumize the inside of the bottle and feed high-purity nitrogen, repeat the operation three times to ensure that the bottle is filled with nitrogen. Inject 10 mL of dry tetrahydrofuran into a syringe to dissolve D 3 After obtaining a clear solution, inject 1.0 mL of n-hexane solution containing 2.5 mol / L n-butyllithium at room temperature to initiate anionic ring-opening polymerization. After keeping stirr...

Embodiment 2

[0062] Preparation of polydimethylsiloxane-polysiloxane grafted cysteine ​​block copolymer: the block length ratio is PDMS:PDMS-g-Cys=3:8, the PDMS block length is 1.5kDa, and the PDMS The -g-Cys block is 4 kDa long. In the PDMS-g-Cys block, the proportion of the chain segments grafted with cysteine ​​groups to the total number of segments (grafting ratio) is 1 / 2.

[0063] (1) In a reaction flask equipped with a magnetic stirring bar, add 3.75g D 3 , and then seal it with a silica gel stopper, vacuumize the inside of the bottle and feed high-purity nitrogen, repeat the operation three times to ensure that the bottle is filled with nitrogen. Inject 10 mL of dry tetrahydrofuran into a syringe to dissolve D 3 After obtaining a clear solution, inject 1.0 mL of n-hexane solution containing 2.5 mol / L n-butyllithium at room temperature to initiate anionic ring-opening polymerization. After keeping stirring at 0-5°C for about 12 hours, take a small amount of the reaction solution t...

Embodiment 3

[0068] Preparation of polydimethylsiloxane-polysiloxane grafted cysteine ​​block copolymer: the block length ratio is PDMS:PDMS-g-Cys=1:2, PDMS block length is 2kDa, PDMS- The g-Cys block is 4 kDa long. In the PDMS-g-Cys block, the proportion of the chain segments grafted with cysteine ​​groups to the total number of segments (grafting ratio) is 1 / 2.

[0069] (1) In a reaction flask equipped with a magnetic stir bar, add 5.0g D 3 , and then seal it with a silica gel stopper, vacuumize the inside of the bottle and feed high-purity nitrogen, repeat the operation three times to ensure that the bottle is filled with nitrogen. Inject 10 mL of dry tetrahydrofuran into a syringe to dissolve D 3 After obtaining a clear solution, inject 1.0 mL of n-hexane solution containing 2.5 mol / L n-butyllithium at room temperature to initiate anionic ring-opening polymerization. After keeping stirring at 0-5°C for about 12 hours, take a small amount of the reaction solution to terminate the act...

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Abstract

The invention discloses a polysiloxane block copolymer of grafted cysteine and a preparation method and application of the polysiloxane block copolymer. The method includes: through ring opening polymerization of active anions, triggering cyclic monomers of hexamethyl cyclotrisiloxane, trimethyl triethylene trioxide and the like to perform ring opening polymerization through n-butyllithium to obtain PDMS (polydimethylsiloxane)-b-PVMS; through radical addition reaction of sulfydryl-vinyl, leading N-acetylcysteine groups to vinyl containing blocks to obtain PDMS-b-(PDMS-g-Acys); finally, subjecting acetyl to hydrolysis under acidic condition to obtain PDMS-b-(PDMS-g-Cys). Solid materials are soaked in a PDMS-b-(PDMS-g-Cys) water solution, an adsorption layer of the block copolymer can be formed on the surface of the materials, and the effect that surface adsorption of protein is reduced is achieved.

Description

technical field [0001] The invention belongs to the field of preparation of functional macromolecular block copolymers, in particular to a polysiloxane block copolymer grafted with cysteine, a preparation method and application thereof. Background technique [0002] The adsorption of protein on the surface of materials is often a prerequisite for biofouling on the surface of materials. Therefore, anti-protein adsorption materials have become a research hotspot in many fields such as medical materials, marine antifouling, and membrane separation. Zwitterionic polymers have shown excellent performance in the study of anti-protein adsorption by forming a "hydration layer" with a barrier effect. However, due to their good water solubility, zwitterionic polymers are often difficult to absorb in aqueous solutions. Hydrophobic surfaces susceptible to protein contamination aggregate to form effective stable adsorption layers, thus limiting their use in many applications requiring re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G77/44B01J20/26B01J20/30
CPCB01J20/264C08G77/44
Inventor 张安强雷雨风林雅铃
Owner SOUTH CHINA UNIV OF TECH
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