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Penicillium t3-1 and its fermentation compound, extraction and purification method and application in anti-allergy

A compound, Penicillium technology, applied in the direction of steroids, microorganism-based methods, biochemical equipment and methods, etc., can solve the negative impact of nutritional intake and quality of life, no active drugs have been found to inhibit sensitizing food antigens, etc. problem, to achieve good application prospects, promote effective application, and the effect of strong anti-allergic activity

Active Publication Date: 2019-09-27
THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current treatment for food allergy is to avoid exposure to allergens or perform desensitization therapy, and no active drug that inhibits allergenic food antigens has been found
Dietary intervention is a crucial part of food allergy management, but it will have a negative impact on the nutritional intake and quality of life of the human body; and the use of antihistamines or hormone drugs is prone to side effects such as drug resistance, so Finding anti-allergic active compounds is especially important

Method used

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  • Penicillium t3-1 and its fermentation compound, extraction and purification method and application in anti-allergy

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Embodiment 1

[0022] In this embodiment, Penicillium commune T3-1 (Penicillium commune T3-1) in the deep-sea fungus is used as raw material to prepare the Penicillium commune fermentation compound shown in formula (I) and formula (II), and the specific steps are as follows:

[0023] (1) Take Penicillium commune T3-1 (Penicillium commune T3-1), add it to the culture medium, let it stand for 35 days, add organic solvent to extract three times, combine the obtained extracts, and concentrate the extracts under low pressure to obtain 28.6g Penicillium fermented crude extract;

[0024] (2) The crude extract of Penicillium fermentation in step (1) is subjected to C18ODS chromatographic column adsorption, and gradient elution is carried out by using methanol aqueous solution;

[0025] (3) Adsorb the active site obtained in step (2) with Sephadex LH-20, and use 1:1 chloroform-methanol solution to elute;

[0026] (4) The active site obtained in step (3) is subjected to 100-200 mesh silica gel column...

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Abstract

The invention discloses Penicillium commune T3-1 (Penicillium commune T3-1) and its fermentation compound, extraction and purification method and application in anti-allergy. The Penicillium commune T3-1 (Penicillium commune T3-1) of the present invention is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M 2017123, the preservation address is China. Wuhan. Wuhan University, and the preservation date is March 2017 15th of May. The structural formula of the compound obtained by the fermentation and extraction of Penicillium commune T3-1 of the present invention is shown in formula (I) and formula (II): it is found through experiments that it has strong anti-allergic activity and can be used for preparing and development of anti-allergic drugs. The invention provides a new compound source for the research and development of anti-allergic drugs, is of great significance to the development of marine drugs in my country, can also promote the effective application of deep-sea biological resources, and has good application prospects.

Description

technical field [0001] The invention belongs to the field of new compounds extracted from marine fungi, more specifically, the invention relates to a new Penicillium commune T3-1 (Penicillium commune T3-1), a class of Penicillium commune fermentation compounds obtained by fermentation and extraction thereof, and corresponding The extraction and purification method and the application of Penicillium fermented compounds in anti-allergy. Background technique [0002] Food allergy, that is, food allergy, refers to the strong reaction of a certain tissue, a certain organ or even the whole body caused by some people after eating a certain food, resulting in various dysfunction or tissue damage, serious Or it may even cause anaphylactic shock. Food allergy is a threat to human life and health, and its incidence has gradually increased in the past few decades, and almost 10% of children suffer from food allergy. The Codex Alimentarius Commission states that common food allergens i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/14C12P33/20C12P7/02C07J73/00C07C43/23A61K31/58A61K31/085A61P37/08C12R1/80
CPCC07C43/23C07J73/003C12P7/02C12P33/20C12N1/145C12R2001/80
Inventor 杨献文牛四文夏金梅范佐旺汤熙翔
Owner THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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