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A kind of preparation technology and application of black garlic polysaccharide extract

A technology of polysaccharide extraction and black garlic extract, which is applied in the direction of drug combination, extracellular fluid disease, blood disease, etc., can solve the problems of less research on pharmacological effects and no application report of anti-platelet aggregation, and achieve good anti-platelet aggregation, Good effect of promoting angiogenesis

Active Publication Date: 2020-06-19
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the pharmacological research on black garlic mainly focuses on lowering blood fat, lowering blood sugar, anti-tumor, improving immunity, and nutritional efficacy. It is mainly played by allicin and sulfur-containing compounds in black garlic. There are few studies on other pharmacological effects of active ingredients, and there are no application reports on anti-platelet aggregation and / or promoting angiogenesis

Method used

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  • A kind of preparation technology and application of black garlic polysaccharide extract
  • A kind of preparation technology and application of black garlic polysaccharide extract
  • A kind of preparation technology and application of black garlic polysaccharide extract

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preparation example Construction

[0027] The invention discloses a preparation process and application of a black garlic polysaccharide extract. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters to realize it. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The application and preparation process of the present invention have been described through the examples, and the relevant personnel can obviously make changes or appropriate changes and combinations to the process and application described herein without departing from the content, spirit and scope of the present invention to realize and Apply the technology of the present invention.

[0028] The preparation process and application of a black garlic polysaccharide extract provided by the present invention will be further described below.

Embodiment 1

[0029] Embodiment 1: Preparation of black garlic polysaccharide extract

[0030] Take 500g of black garlic, add water 10 times the weight of black garlic according to the weight ratio, heat to 100°C, continue heating and extracting for 15min, filter directly, separate solid and liquid, take supernatant to obtain black garlic extract; The solvent of the black garlic extract is recovered at a temperature lower than 80°C to obtain a black garlic concentrate; according to the volume ratio, add 2 times the volume of an ethanol solvent with a mass fraction of 100% to the black garlic concentrate, stir evenly, and place in Stand still at 0°C for 3 hours, take the precipitate, wash once with 85% ethanol solvent, and then dissolve the precipitate in water to obtain the black garlic polysaccharide extract.

Embodiment 2

[0031] Embodiment 2: the preparation of black garlic polysaccharide extract

[0032] Take 100g of black garlic, add 50 times the weight of black garlic in an ethanol solvent with a mass fraction of 15%, heat to 80°C, continue heating and extracting for 60 minutes, separate solid and liquid, and take the supernatant to obtain black garlic extraction solution; the black garlic extract is recovered at a temperature lower than 62°C to obtain a black garlic concentrate; according to the volume ratio, add 5 times its volume of ethanol solvent with a mass fraction of 90% to the black garlic concentrate, and stir evenly , placed at 25°C for 12 hours, the precipitate was taken, washed twice with ethanol solvent with a mass fraction of 75%, and then the precipitate was dissolved in water to obtain the black garlic polysaccharide extract.

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Abstract

The present invention relates to the technical field of plant extraction, and discloses a preparation process and applications of a black garlic polysaccharide extract. According to the present invention, the pharmacological test results show that the black garlic polysaccharide extract extracted from black garlic through the preparation process has good effects of platelet aggregation resistance and angiogenesis promoting, and is non-toxic in a gene barchydanio rerio var embryo toxicity test; and the obtained black garlic polysaccharide extract can be used in anti-platelet aggregation and / or angiogenesis promoting related products through pharmaceutical pharmacy knowledge.

Description

technical field [0001] The invention relates to the technical field of plant extraction, in particular to a preparation process and application of a black garlic polysaccharide extract. Background technique [0002] Black garlic (black garlic), also known as black garlic, fermented black garlic, black garlic head, is made of fresh raw garlic with skin and fermented in a high-temperature and high-humidity fermentation box for 60-90 days, allowing it to ferment naturally. into food. [0003] At present, the number of cardiovascular patients in my country has exceeded 290 million, the annual incidence of coronary heart disease has exceeded 64‰, and the annual incidence of stroke is 165-245 / 100,000. In the past five years, cerebral apoplexy has been increasing at a rate of nearly 13% per year, and in some areas, 40% are middle-aged people. A large number of experimental and clinical data show that the occurrence and development of cardiovascular and cerebrovascular diseases su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61P7/04A61P9/00
CPCC08B37/0003
Inventor 赵静李绍平葛亚中余庆涛马忠华
Owner INFINITUS (CHINA) CO LTD
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