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A kind of composite developing thermosensitive gel embolic agent, preparation method and application thereof

A technology of sensitive gel embolizing agent and temperature-sensitive gel, which is applied in the field of composite temperature-sensitive gel matrix, can solve the problems of unable to continuously exert the embolic function, incomplete embolization effect, unstable temperature-sensitive gel, etc. Stability, the effect of improving stability

Active Publication Date: 2021-05-04
苏州申润医疗科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A single temperature-sensitive gel has the disadvantage of being unstable. It will undergo obvious erosion in the solution until the structure dissociates, and cannot continue to perform the embolization function, resulting in an incomplete embolization effect.

Method used

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  • A kind of composite developing thermosensitive gel embolic agent, preparation method and application thereof
  • A kind of composite developing thermosensitive gel embolic agent, preparation method and application thereof
  • A kind of composite developing thermosensitive gel embolic agent, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation and Characterization of Composite Developing Thermosensitive Gel with Different Components

[0042] Take 5000mg of hydroxymethylcellulose and add 100ml of iodixanol solution with a concentration of 20mg I / mL, avoid light, stir at room temperature for 24h, stir well, then add 5000mg of sodium alginate and 1mg of arsenic trioxide, and continue stirring at room temperature for 24h , Stir well. In the above solution, add F127 so that the concentration of F127 is 5%, and dissolve it in the dark under an ice bath at 0°C to obtain a composite thermosensitive gel of iodixanol, sodium alginate, hydroxy C1-4 alkyl cellulose, F127 and arsenic trioxide Glue solution, spare.

[0043] Prepare CaCl with a concentration of 5mol / L 2 solution, set aside.

[0044] At room temperature, the composite developing thermosensitive gel was divided into two parts, one part was the composite developing thermosensitive gel, and the other was the composite developing thermosensitive g...

Embodiment 2

[0047] Preparation of Arsenic Trioxide Composite Imaging Thermosensitive Gel and Its Application in Renal Artery Embolization

[0048] Take 500mg of hydroxy C1-4 alkyl cellulose and add 100ml of iodixanol solution with a concentration of 200mg I / mL, stir at room temperature in the dark for 24h, stir evenly, then add 1mg of sodium alginate and 1mg of arsenic trioxide, keep in the dark at room temperature Stir for 24h, stir evenly. In the above solution, add P105 so that the concentration of P105 is 30%, and dissolve in an ice bath at 0°C in the dark to obtain a composite developing thermosensitive gel solution, which is ready for use. Prepare Ca(CH 3 COO) 2 solution, set aside.

[0049] The prepared composite imaging thermosensitive gel was injected into the normal rabbit renal artery, and the embolization effect was observed. In normal rabbits, the right femoral artery was cannulated to the opening of the left renal artery, and 1ml of composite imaging thermosensitive gel ...

Embodiment 3

[0051] Preparation of docetaxel composite imaging thermosensitive gel and application of left gastric artery embolization

[0052] Get 1000mg of hydroxy C1-4 alkyl cellulose and add 100ml of iohexol solution with a concentration of 20mg I / mL, and stir at room temperature for 24 hours in the dark, stir evenly, then add 50mg of sodium alginate and 10mg of docetaxel, and keep in the dark Stir at room temperature for 24h, stir evenly. In the above solution, add F127 so that the concentration of F127 is 25%, and dissolve in an ice bath at 0°C in the dark to obtain a composite developing temperature-sensitive gel solution for future use. Prepare CaCl at a concentration of 0.001mol / L 2 solution, set aside.

[0053] The prepared composite imaging thermosensitive gel was injected into the left gastric artery of normal rabbits, and the embolization effect was observed. Intubate the right femoral artery of normal rabbits to the opening of the left gastric artery, inject 1ml of compoun...

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Abstract

The invention relates to a composite developing thermosensitive gel embolic agent, a preparation method and an application thereof. First, the mixed aqueous solution of the anti-tumor active substance, the temperature-sensitive material and the developing agent is prepared into a composite developing thermosensitive gel, and then a composite developing thermosensitive gel embolism is formed with a coagulant on site. The temperature-sensitive material is hydroxy C1-4 alkyl cellulose, pramonic, alginate or their mixture; the anti-tumor active substance drug is arsenic trioxide, docetaxel, cisplatin, carboplatin, nedaplatin, arsenic Saliplatin, lobaplatin, miplatin, siRNA or their mixtures; the developer is a water-soluble developer such as iodixanol, ioversol or iohexol. The preparation method of the present invention is simple and convenient, suitable for industrialized large-scale production, especially suitable for preparing embolism preparations for hemorrhagic diseases with good biodegradability and biocompatibility, and especially suitable for preparing and treating liver cancer, kidney cancer, lung cancer, prostate cancer, Composite imaging thermosensitive gel embolism for uterine fibroids or spleen tumors.

Description

technical field [0001] The invention belongs to a composite thermosensitive gel matrix, in particular to the application of a composite imaging thermosensitive gel embolic agent in the embolization treatment of liver tumors. Background technique [0002] Transcatheter arterial chemoembolization (TACE) is to inject chemotherapy drugs and embolic agents into diseased blood vessels through the guidance of interventional arterial catheterization. Necrosis and shrinkage in order to control bleeding; on the other hand, increase the local drug concentration and prolong the contact time between drugs and tumor tissues, so as to achieve the purpose of treating tumors and vascular lesions and eliminating the function of diseased organs. Therefore, embolic agents play a key role in arterial perfusion embolization. Currently clinically used embolic agents include liquid embolic agents and granular embolic agents. Although these embolic agents have been continuously developed and impro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K9/06A61K33/36A61K33/243A61K31/337A61K47/10A61K47/38A61K47/36A61K47/02A61P35/00A61P7/04
CPCA61K9/0024A61K9/06A61K31/337A61K33/24A61K33/36A61K47/02A61K47/34A61K47/36A61K47/38A61K49/0438
Inventor 段友容沈鸣黄莉莉
Owner 苏州申润医疗科技有限公司
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