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Composition for treating onychomycosis and its preparation method

A composition and technology of onychomycosis, applied in the direction of drug combination, medical preparations containing active ingredients, drug delivery, etc., can solve glacial acetic acid contact dermatitis and chemical paronychia, tingling or burning sensation, fungus Infection is difficult to cure and other problems, to achieve the effect of promoting the growth of new nails, overcoming irritation and burning sensation, and avoiding chemical paronychia

Active Publication Date: 2017-11-21
GUIZHOU SHENQI PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to cure fungal infections, the effect is poor, and it is easy to relapse, and it is also used for non-fungal infections, so it is difficult to achieve satisfactory curative effect with only fungicidal drugs
[0004] After checking the literature, acetic acid has been confirmed by a large number of research literature to have a clear bactericidal function, but glacial acetic acid is easy to cause contact dermatitis and chemical paronychia, and has stinging or burning sensation

Method used

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  • Composition for treating onychomycosis and its preparation method
  • Composition for treating onychomycosis and its preparation method
  • Composition for treating onychomycosis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Prescription: glacial acetic acid 18kg, live beads 36kg.

[0055] Preparation Process:

[0056] (1) Remove the live beads, wash them, pasteurize them at 65°C for 30 minutes, break them up and mix them evenly, put them into the freezer tray, put them into the freezer of a vacuum freeze-drying box for pre-freezing, and put them in a freezer at a temperature of -50°C Keep at low temperature for 3 hours; transfer the pre-frozen live beads to the freeze-drying warehouse for sublimation drying, slowly raise the temperature, the vacuum degree is 40-70Pa, and keep for 7 hours; Afterwards, live bead freeze-dried powder was obtained.

[0057] (2) Add glacial acetic acid to the raw material obtained in step (1) and mix evenly, pulverize and set aside.

[0058](3) 52g of benzoic acid is fully dissolved in 95% ethanol and set aside; 90g of stearic acid, 45g of glyceryl monostearate, and 35g of stearyl alcohol are heated to 80°C and completely melted, adding 50g of liquid paraffin ...

Embodiment 2

[0061] Prescription: Glacial acetic acid 17g, live beads 38g

[0062] Preparation:

[0063] (1) Shell the live beads, wash them, pasteurize them at 60-70°C for 30 minutes, break them up and mix them evenly, put them into the tray of the freeze dryer, put them into the freezer of the vacuum freeze-drying box for pre-freezing, and put them in the freezer at a temperature of - Keep at 50°C for 2 hours; transfer the pre-frozen live beads to the freeze-drying chamber for sublimation drying, slowly raise the temperature, and keep the vacuum at 40Pa, and keep for 6h; Live beads freeze-dried powder.

[0064] (2) Add glacial acetic acid to the raw materials obtained in step (1) and mix well, pulverize and set aside

[0065] (3) Add 100 g of benzoic acid to the powder obtained in step (2), stir and dissolve, add 95% ethanol, glycerin and water, stir evenly, and make a spray.

Embodiment 3

[0067] Prescription: glacial acetic acid 20g, live beads 34g

[0068] (1) Shell the live beads, wash them, pasteurize them at 60-70°C for 30 minutes, break them up and mix them evenly, put them into the tray of the freeze dryer, put them into the freezer of the vacuum freeze-drying box for pre-freezing, and put them in the freezer at a temperature of - Keep at 50°C for 5h; transfer the pre-frozen live beads to the freeze-drying chamber for sublimation drying, slowly raise the temperature, and keep the vacuum at 40-70Pa, and keep for 8h; continue to raise the temperature for analytical drying, keeping the vacuum at 10-30Pa, After 5 hours, the freeze-dried powder of live beads was obtained.

[0069] (2) Add glacial acetic acid to the raw material obtained in step (1) and mix evenly, pulverize and set aside.

[0070] (3) Add 120 g of benzoic acid to the powder obtained in step (2), add 95% ethanol and stir to dissolve, then add 20 g of glycerin, add water and stir evenly to make...

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Abstract

The invention relates to a composition for treating onychomycosis and a preparation method thereof. The composition is prepared from the following raw materials by weight: 16-24 parts of glacial acetic acid and 32-40 parts of the extract of an egg with a chicken embryo inside. The composition has the advantages that synergistic effect is obtained by preparing the composition from glacial acetic acid and the extract of the egg with the chicken embryo according to a specific proportion; rich nutritional ingredients in the egg with the chicken embryo inside re beneficial for the growth of new nails and shortening the course of treatment; meanwhile, the glacial acetic acid skin is beneficial for overcoming irritation and side effect on skin; and the composition is short in medication time, causes no pain, enables nails to be bright and smooth, and has remarkable treatment effect.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a composition for treating onychomycosis and a preparation method thereof. Background technique [0002] Onychomycosis (onychomycosis) refers to the disease caused by dermatophytes invading the nail plate or subungual tissue. Onychomycosis is a nail infection caused by fungi other than dermatophytes and yeasts. Onychomycosis (tinea unguium) is a disease caused by dermatophytes invading the nail plate or subungual tissue. Onychomycosis is a nail infection caused by fungi other than dermatophytes and yeasts. Tinea manus and pedis (tinea manus and pedis) refers to the infection caused by dermatophytes invading the fingers, between the toes, and the palms and soles. Wearing public slippers in swimming pools and public bathrooms is susceptible to tinea pedis, and tinea manuum is often infected by tinea pedis. The pathogens are mainly Trichophyton rubrum, Trichophyton mentagroph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/57A61P17/00A61P31/10A61K31/19
CPCA61K9/0014A61K31/19A61K35/57A61K2300/00
Inventor 张芝庭张涛涛
Owner GUIZHOU SHENQI PHARMA RES INST
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