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Use of hm-3 and platinum, paclitaxel or citabine drugs in the preparation of solid tumor drugs

A paclitaxel, solid tumor technology, applied in antitumor drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as toxic side effects, complex drug properties, tumor cell drug resistance, complex pathogenesis, etc., to reduce toxic side effects, expand Effects of therapeutic spectrum, significant social value, and market value

Active Publication Date: 2017-01-04
NANJING ANJI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for specific drugs, due to the complexity of the properties of the drugs, how to use them in combination has always been a difficult problem for those skilled in the art.
[0006] For the drugs for the treatment of tumors, because tumor cells have strong drug resistance and the pathogenesis is complex, it is difficult to achieve an effective tumor inhibitory effect by using a certain chemotherapeutic drug alone, and it is necessary to use drugs with different mechanisms in combination to achieve an effective effect. The therapeutic effect of
However, there are interactions between drugs. When drugs with different mechanisms are used in combination, it is necessary to verify whether they can achieve the best therapeutic effect through experiments. If they are not used properly, not only the effect is not good, but also more toxic side effects will occur.

Method used

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  • Use of hm-3 and platinum, paclitaxel or citabine drugs in the preparation of solid tumor drugs
  • Use of hm-3 and platinum, paclitaxel or citabine drugs in the preparation of solid tumor drugs
  • Use of hm-3 and platinum, paclitaxel or citabine drugs in the preparation of solid tumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 The inhibitory effect of HM-3 combined with oxaliplatin and docetaxel on human lung cancer H460 transplanted tumor in nude mice

[0045] Lung cancer tissues in the vigorous growth stage were taken and ground under sterile conditions, and prepared into 1×10 7 / mL cell suspension, planted in the right armpit of mice with 0.1mL. When the tumor volume reaches 100mm 3 The diameter of the transplanted tumor was measured with a vernier caliper on the left and right, and the anti-tumor effect of the tested animals was dynamically observed. It is administered by tail vein injection or subcutaneous injection, and the dosage regimen is shown in Table 1. Tumor diameters were measured every other day. The administration volume is 0.2ml / only. The negative control was injected with the same volume of saline in the tail vein. After 21 days, the mice were sacrificed, and the tumor mass was removed and weighed. The formula for calculating tumor volume (TV) is:

[0046] T...

Embodiment 2

[0062] Example 2 The inhibitory effect of HM-3 combined with oxaliplatin and Xeloda on transplanted tumors of human liver cancer SMMC-7721 in nude mice

[0063] Liver cancer tissues in vigorous growth phase were taken and ground under sterile conditions, and prepared into 1×10 7 / mL cell suspension, planted in the right armpit of mice with 0.1 mL. Others participate in Example 1.

[0064] The test was divided into 7 groups, HM-3 group with 8 rats in each group, other treatment groups with 10 rats in each group, and control group with 13 rats. See Table 3 for the specific dosage regimen.

[0065] Table 3 Administration settings

[0066]

[0067] Tumor weight (g) and tumor inhibition rate (%) when table 4 was treated on the 21st day

[0068]

[0069]

[0070] The data analysis software was SPSS, and the average tumor weight of each group was expressed as mean±SD. According to the T test, the tumor inhibition rate was calculated = (tumor weight of the negative group ...

Embodiment 3

[0074] Embodiment 3 HM-3 combines docetaxel, oxaliplatin to the inhibitory effect of human breast cancer MDA-MB-231 nude mouse xenograft tumor

[0075] Breast cancer tissues in vigorous growth stage were taken and ground under sterile conditions, and prepared into 1×10 7 / mL cell suspension, planted in the right armpit of mice with 0.1 mL. Other model preparation methods are referring to embodiment 1.

[0076] The test was divided into 8 groups, including 12 rats in the negative control group, 8 rats in the HM-3 group, and 10 rats in each of the other treatment groups. See Table 1 in Example 1 for the specific dosage regimen. After the 21st day of treatment, the nude mice were dissected, tumors were taken, and the tumor inhibition rate was determined.

[0077] Table 5 Tumor weight (g) and tumor inhibition rate (%)

[0078]

[0079] The data analysis software was SPSS, and the average tumor weight of each group was expressed as mean±SD. Tumor inhibition rate=(tumor weig...

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Abstract

The invention discloses application of HM-3 and platinum, paclitaxel or capecitabine medicine for preparing a solid tumor medicine, belonging to the field of medicines for treating tumor. Platinum, paclitaxel or capecitabine antimetabolites serve as active components and accompanied by a pharmaceutically acceptable carrier to be prepared into various pharmaceutically acceptable preparations. A plurality of experiments show that an integrin blocker HM-3 is clear in target; the integrin blocker HM-3 is reasonably used together with the platinum, paclitaxel or capecitabine for effectively suppressing growth of tumors in lung cancer, liver cancer, stomach cancer, breast cancer, cervical cancer, ovarian cancer, intestinal cancer, and the like. The combined medicine serves as a medicine and is capable of effectively treating tumors; the combined medicine is scientific, reasonable, feasible and effective, so that the treatment spectrum for treating the tumors is greatly expanded; the toxic and side effects are reduced; the HM-3 and platinum, paclitaxel or capecitabine medicine is prominent in social value and market value.

Description

technical field [0001] The present invention relates to the use of a drug for treating tumors, more specifically the use of HM-3 and platinum, paclitaxel or tabine drugs in the preparation of solid tumor drugs. . Background technique [0002] Tumor is a complex disease, and it is difficult to achieve the desired therapeutic effect by using a single drug. Currently, a combination of drugs is often used for clinical treatment. The advantage of combination drug in tumor treatment is to enhance the curative effect, reduce the occurrence of adverse reactions, and prevent the tumor from developing drug resistance. Rational drug combination based on the mechanism of action of antineoplastic drugs is one of the important advances in chemotherapeutic drug therapy in recent years. Combination of antineoplastic drugs with different mechanisms of action can often enhance the efficacy. Combining alkylating agents (such as cyclophosphamide or carmustine) that damage DNA structure and f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/10A61P35/00A61K33/24A61K31/337A61K31/282A61K31/7068A61K31/706
Inventor 徐寒梅
Owner NANJING ANJI BIOLOGICAL TECH CO LTD
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