Application of Papulospora instead of Dendropanax dentiger (Harms) Merr. in preparation of anti-inflammatory-immunity drugs

Abstract

The invention discloses the application of silk mulberry (genus name Papulospora) instead of tree ginseng in the preparation of anti-inflammatory and immune drugs. The inventor of the present invention takes the seed fruit of tree ginseng, randomly samples from the naturally dried seed fruit, isolates and purely cultivates a kind of fungus in its multiple seed fruits, cultures colonies and observes with a microscope, and has been identified as Silk mulberry mold (genus name Papulospora). Tests have shown that it has good curative effect in animal drug effect model experiments. Moreover, the large-scale cultivation of this fungus is used to realize factory production, and its water extract can replace the traditional Chinese medicine tree ginseng, and it can be used in the development and application of drugs for treating rheumatism and rheumatoid arthritis. Medicinal fungi are clear and easy to control because of their relatively few components. As a substitute and raw material for Chinese medicinal tree ginseng, they have low production costs, short production cycles, easy factory production, relatively small side effects, and are not easy to produce drug resistance. It has many advantages such as safety, economy and applicability, so it can replace the rare Chinese medicinal tree ginseng.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of the fungus Phylospora (genus name Papulospora) in the preparation of anti-inflammatory and immune drugs instead of tree ginseng. Background technique [0002] Tree ginseng (Dendropanax dentiger (Harms) Merr.) is a medicinal plant of Araliaceae (Araliaceae). In terms of plant classification, tree ginseng belongs to the same family. Araliaceae plants have many uses in medicine , it is in the same family as the well-known traditional Chinese medicines ginseng, Wujiapi, and Panax notoginseng. Ginseng, Sanqi, and Wujiapi are famous medicinal materials. It is mainly distributed in Jiangxi, Guangdong, Guangxi and other high mountains south of the Yangtze River with an altitude of more than 500 meters. Alkyne, saponin, terpenoid, etc. have been found in the chemical constituents of the genus Ginseng. Saponins are commonly found in Araliaceae, such as ...

AI Technical Summary

Problems solved by technology

[0009] It can be seen that as a preparation of anti-inflammatory and immune drugs, tree ginseng has the problem of too scarce medicinal resources, and it belongs to rare Chinese medicinal materials. It is very difficult to reproduce at present. It takes more than five years to grow into a useful medicinal material, and the cycle is too long.

However, no substitutes that can replace tree ginseng as an anti-inflammatory immune drug have been found so far.

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