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Preparation method of Baoxinning granules

A technology of Baoxinning and granules, which is applied in the field of preparation of Baoxinning granules, and can solve the problems that the resources of Chinese herbal medicines cannot meet the demand.

Inactive Publication Date: 2017-11-24
ZHENGZHOU HANDU PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the excessive and disorderly development of traditional Chinese medicine resources has led to the gradual inability of commonly used traditional Chinese medicinal materials to meet the needs. In limited resources, it is urgent to improve the utilization rate of traditional Chinese medicine raw materials

Method used

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  • Preparation method of Baoxinning granules
  • Preparation method of Baoxinning granules
  • Preparation method of Baoxinning granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of Baoxinning granules, comprising the steps of:

[0021] (1) Preparation of Danshen dry extract: Take 1494.7kg of Danshen, crush it into a coarse powder, put it into a percolation tank, use 95v% ethanol as a solvent (the total amount is 10 times the weight of Salvia miltiorrhiza), soak for 24 hours, and carry out infiltration. percolation at a flow rate of 3mL / min and collected until the first percolation liquid is obtained; then use 75v% ethanol as a solvent (the total amount is 10 times the weight of Salvia miltiorrhiza) for percolation at a rate of 3mL / min The flow rate of the percolation was collected until the second percolate was obtained; water with 6 times the weight of the dregs was added to decoct the remaining dregs in the percolation tank for 2 hours, filtered, and the filtrate was combined with the above percolate and concentrated To the clear ointment that relative density is 1.08~1.12, spray drying, obtains 180.4kg salvia miltiorrhiz...

Embodiment 2

[0030] A preparation method of Baoxinning granules, comprising the steps of:

[0031] (1) Preparation of Danshen dry extract: Take 2989.4kg of Danshen, crush it into a coarse powder, put it into a percolation tank, use 95v% ethanol as a solvent (the total amount is 12 times the weight of Salvia miltiorrhiza), soak for 24 hours, and carry out infiltration. percolation at a flow rate of 1mL / min and collected until the first percolation liquid is obtained; then use 50v% ethanol as a solvent (the total amount is 10 times the weight of Salvia miltiorrhiza) for percolation at a flow rate of 1mL / min The flow rate of the percolation and collection until the second percolate is obtained; add water 5 times the weight of the dregs to decoct the remaining dregs in the percolation tank for 3 hours, filter, and combine the filtrate with the above percolate and concentrate To the clear ointment that relative density is 1.08~1.12, spray drying, obtains 360.7kg salvia miltiorrhiza dry extract;...

Embodiment 3

[0040] A preparation method of Baoxinning granules, comprising the steps of:

[0041] (1) Preparation of Danshen dry extract: Take 1024.7kg of Danshen, crush it into a coarse powder, put it into a percolation tank, use 95v% ethanol as a solvent (the total amount is 11 times the weight of Salvia miltiorrhiza), soak for 24 hours, and carry out infiltration. percolation at a flow rate of 2mL / min and collected until the first percolation liquid is obtained; then use 60v% ethanol as a solvent (the total amount is 10 times the weight of Salvia miltiorrhiza) for percolation at a flow rate of 2mL / min The flow rate of the percolation and collection until the second percolate is obtained; add water 6 times the weight of the dregs to decoct the remaining dregs in the percolation tank for 3 hours, filter, and combine the filtrate with the above percolate and concentrate To the clear ointment that relative density is 1.08~1.12, spray drying, obtains 123.7kg salvia miltiorrhiza dry extract;...

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Abstract

The invention provides a preparation method of Baoxinning granules, and belongs to the technical field of pharmaceutical preparations. The Baoxinning granules are prepared from the following raw materials: 0.15 to 0.17 part of radix et rhizoma salviae miltiorrhizae dry extract, 0.07 to 0.09 part of Chinese angelica dry extract, 0.07 to 0.09 part of fructus aurantii dry extract, 0.5 to 0.7 part of fresh ginger dry extract, 0.09 to 0.15 part of radix notoginseng powder, 0.1 to 2.0 parts of steviosin, 1 to 8 parts of xylitol, 0.2 to 0.7 part of sodium carboxymethyl starch and 0.15 to 1.5 parts of beta-cyclodextrin. The preparation method comprises the following steps: firstly, carrying out a technological process of drying, crushing, alcohol extraction, filtering, concentration, drying and the like on radix et rhizoma salviae miltiorrhizae, Chinese angelica and fructus aurantii to obtain extracts; then, carrying out water extraction, filtering, concentration and drying and the like on fresh ginger to obtain a dry extract; taking ethanol as an adhesive and granulating to obtain the Baoxinning granules. According to the preparation method of the Baoxinning granules, a traditional preparation is improved, so that an applicable crowd is expanded; the utilization rate of traditional Chinese medicines is extremely improved, and the pharmacological effect and the clinical curative effect of Baoxinning are realized better.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a preparation method of Baoxinning Granules. Background technique [0002] Baoxinning is a pure traditional Chinese medicine preparation, which can promote blood circulation, remove blood stasis, promote qi and relieve pain, and can effectively improve the function of the cardiovascular system. It is an ideal drug for clinical treatment of angina pectoris, arrhythmia, coronary heart disease and other diseases. [0003] Its prescription is composed of Danshen, Panax notoginseng, Angelica, Citrus aurantium and ginger. In the prescription, Danshen promotes blood circulation, removes blood stasis and relieves pain, clears heart and eliminates troubles, and is used as the monarch drug; Angelica nourishes blood, activates blood and relieves pain, Sanqi dispels blood stasis and stops bleeding, reduces swelling and relieves pain, and Fructus Citrus aur...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/16A61P9/10
CPCA61K9/1652A61K36/232A61K36/258A61K36/537A61K36/752A61K36/9068A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 王瑞玲李俊霞周遂成白艳鹤田广林
Owner ZHENGZHOU HANDU PHARMA GROUP