Polyester carbonic ester anhydride 3D printing bio-ink, and 3D printing method

A polyester carbonate anhydride, 3D printing technology, applied in the biological field, can solve the problems of 3D printing tissue difficult to grow continuously, metabolites unable to discharge, and cells difficult to obtain nutrients.

Active Publication Date: 2017-11-28
HANGZHOU MEDZONE BIO-TECH CO LTD
View PDF6 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In fact, it is precisely because of the above reasons that the existing 3D bioprinting technology can only print a very thin layer of tissue, because there are no nutrient channels such a

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] Further, the present invention also provides the preparation method of the 3D printing bio-ink described in Example 1, comprising the following steps: cross-linked hyaluronic acid with a mass fraction of 1%-5%, poly(N -isopropylacrylamide), poly(N,N-diethylacrylamide) of mass fraction 3%-5%, polymethyl vinyl ether of mass fraction 3%-5%, mass fraction of 3%-5 % of polyethylene glycol-polyoxyethylene (PEG-PEO) blended with the remaining amount of deionized water, stirred for 30 minutes, and left to stand for 1 to 6 hours to make the hydrogel; mix the hydrogel with the The biological cells are evenly mixed into the 3D printing bio-ink.

[0035] 3D printing bio-ink example 2

[0036] The aforementioned Example 1 provides a 3D printing bio-ink suitable for the present invention, the 3D printing bio-ink is a gel ink, the gel ink is composed of hydrogel and biological cells, and can be obtained by 3D printing without A model supported by brackets. Of course, those skilled ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a polyester carbonic ester anhydride 3D printing bio-ink, and a 3D printing method. The polyester carbonic ester anhydride 3D printing bio-ink is composed of a gel ink and a support ink; the gel ink is composed of a hydrogel and biological cells; the hydrogel contains a PLGA-PEG-PLGA triblock copolymer with temperature responsiveness; the support ink is a polyester carbonic ester anhydride copolymer (P(LLA-TMC-SA)copolymer) with surface degradation characteristics. The 3D printing bio-ink possesses thermosensitivity and surface degradable performance, and multicomponent gradient printing and coaxial printing are adopted based on requirements of 3D biologically printed scaffold in vivo degradation structure controllable maintenance so as to obtain models which contain biological cells and are supported by scaffolds with surface controllable degradability, nutrient and metabolism channels with porous structures are obtained, and it is beneficial for obtaining of larger and thicker tissue structures via 3D printing.

Description

technical field [0001] The present invention relates to the field of biotechnology, especially the field of 3D bioprinting technology, in particular to a surface-degradable polyester carbonate anhydride 3D printing bioink and a 3D printing method. Background technique [0002] 3D printing can quickly and efficiently manufacture personalized products, so it is gradually being introduced into the biomedical industry, with a view to using 3D printing technology for tissue and organ transplantation. "The Latest Research and Application of Bio-3D Printing" (Powder Metallurgy Industry, Volume 25, No. 4, August 2015, Zhang Hongbao, etc.) introduced the application of 3D bio-printing technology into different levels, which is quoted here as refer to. The basic method of higher-level 3D bioprinting is to inoculate living cells into a biocompatible and finally biodegradable scaffold, and then culture them in a bioreactor, so that the cells rely on the space formed by the scaffold to ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C09D11/30C09D11/38B29C64/106B33Y10/00B33Y70/00
CPCB33Y10/00B33Y70/00C09D11/30C09D11/38
Inventor 凌赟裴明黎张洁李杰甘志鹏王利群
Owner HANGZHOU MEDZONE BIO-TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap