Preparing method for sodium alginate wound application with thrombin

An alginate and thrombin technology, applied in the field of medical care, can solve the problems of inability to moisturise wounds, stop bleeding, apply a single core, and cannot meet the needs of clinical doctors and patients, so as to promote wound healing and reduce sensitization. rate, the effect of increasing the contact area

Active Publication Date: 2017-12-01
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the core of most application products is still relatively simple. This kind of composite material only absorbs wound exudate when used on wounds, and cannot achieve the coexistence of wound moisturizing and hemostasis.
[0005] With the development of functional dressings, wound dressing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0032] Example 1:

[0033] A preparation method of alginate wound dressing with thrombin, the preparation process is as follows:

[0034] (1) Configure the ethanol aqueous solution of thrombin, the volume ratio of ethanol to water is 2:1, and the thrombin content is 50 units / ml;

[0035] (2) Put the long alginate fiber into a reaction tank containing thrombin ethanol water solution for constant temperature soaking. The reaction tank is equipped with an "S" channel, the soaking time is 0.5h, and the temperature is 30°C;

[0036] (3) After soaking, pull the long fiber bundles out of the reaction tank and dry them in an oven at a drying temperature of 35°C and a drying time of 1h;

[0037] (4) After drying, cut into a certain length of alginate short fibers with thrombin, and crimp the short fibers. The length of the cut short fibers is 38mm, and the number of crimps is 3 / cm;

[0038] (5) The short fiber is woven into a non-woven fabric through non-woven processes such as opening, carding, ...

Example Embodiment

[0042] Example 2:

[0043] A preparation method of alginate wound dressing with thrombin, the preparation process is as follows:

[0044] (1) Configure the ethanol aqueous solution of thrombin, the volume ratio of ethanol to water is 3:1, and the thrombin content is 100 units / ml;

[0045] (2) Put the long alginate fiber into a reaction tank containing thrombin ethanol water solution for constant temperature soaking. The reaction tank is equipped with an "S" channel, the soaking time is 1h, and the temperature is 35℃;

[0046] (3) After soaking, pull the long bundle of fibers out of the reaction tank and dry in an oven at a drying temperature of 37°C and a drying time of 2h;

[0047] (4) After drying, cut into a certain length of alginate short fiber with thrombin, and crimp the short fiber, the length of the cut short fiber is 60mm, and the number of crimps is 4 / cm;

[0048] (5) The short fiber is woven into a non-woven fabric through non-woven processes such as opening, carding, netting...

Example Embodiment

[0052] Example 3: Hemostatic performance test

[0053] Test group: The product prepared in Example 2 is selected as the test group;

[0054] Control group: Gauze hemostatic products on the market are the control group.

[0055] The test steps are as follows:

[0056] (1) According to 1ml / kg, slowly inject 3% sodium pentobarbital into the ear vein of the rabbit for anesthesia, then put a wound towel on the left ventral side of the rabbit, and disinfect the surgical site with iodine and 75% alcohol.

[0057] (2) Make a 5.0cm longitudinal incision along the left inner edge, about 1cm to the left of the mid-abdominal line, cut the abdominal muscles to the peritoneum, and cut the peritoneum.

[0058] (3) Use 2 fingers or tweezers to find out the spleen of the rabbit, and use normal saline to keep the spleen moist.

[0059] (4) Blank control group: On the spleen surface, use a scalpel to make two symmetrical wounds 1 cm long and 1 mm deep along the long axis of the spleen, with active bleeding ...

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Abstract

The invention relates to the field of medical care, in particular to a preparing method for sodium alginate wound application with thrombin. The preparing method comprises the following steps that an ethanol aqueous solution of the thrombin is configured, then sodium alginate long beam fiber is put into a reaction tank of the thrombin ethanol aqueous solution for constant temperature soaking, sodium alginate short fiber is prepared through drying and cutting after soaking, the short fiber is curled, non-woven fabrics are prepared through non-woven processes such as opening and scutching, carding, lapping and needling and cut into application cores of needed sizes, the application cores, silicone hydrogel membranes with holes, a polyurethane film adhesive tape and an anti-adhesive layer are composited through an application machine, and finally, a finished product of the sodium alginate wound application with the thrombin can be prepared. According to the composite application prepared through the preparing method, activity of the thrombin can be maintained to the utmost extent, the excellent hemostatic and absorption performance is achieved, meanwhile, adhesion of the application and wound can be prevented, a moist healing environment is provided for the surface of the wound, and wound healing is prompted.

Description

technical field [0001] The invention relates to the field of medical care, in particular to a preparation method of an alginate wound dressing with thrombin. Background technique [0002] The skin is the largest organ of the human body and the first line of defense between the human body and the external environment. It plays an important role in protecting the stability of the internal environment of the body and resisting the stimulation of the external environment and the invasion of pathogenic bacteria. [0003] In the field of medical care, researchers are paying more and more attention to how to better care for the skin, and the practicability and convenience of products are particularly important. Wound dressing has a good protective effect on the wound, avoiding secondary pollution from the outside, reducing the risk of infection for patients, and bringing many conveniences to people. [0004] However, the core of most application products is still relatively simple...

Claims

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Application Information

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IPC IPC(8): A61L15/38A61L15/28A61L15/44A61L15/50A61L15/42
CPCA61L15/28A61L15/38A61L15/42A61L15/44A61L15/50A61L2300/412A61L2300/418A61L2400/04C08L5/04
Inventor 卢亢陈锦涛徐海涛
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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