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Methods and applications for increasing the content of active ingredients, consistency of chemical composition and/or therapeutic benefits of plants of the genus Larnia

A technology of Larnia and plants, which is applied in the field of processing and improvement of Larnia plants, and can solve the problems of excessive sulfur dioxide residue, easy mildew and qualitative change, and harm to human health, etc.

Active Publication Date: 2021-08-27
CHUNG JEN JUNIOR COLLEGE NURSING HEALTH SCI & MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When Chinese herbal medicines are harvested, the water content is high. If they are not processed in time, they are easy to rot and deteriorate, which seriously affects the quality, clinical efficacy and economic benefits of medicinal herbs.
[0005] Taking the drying processing of medicinal materials as an example, the traditional drying methods relying on sun drying or shade drying are inefficient, and there is a large deviation between shade drying and sun drying due to reasons such as not drying in time or inconsistent drying conditions, thus affecting the quality of medicinal materials
[0006] In order to prevent mildew and corruption of medicinal materials, some farmers use sulfur fumigation for processing, which may easily cause excessive sulfur dioxide residues and endanger human health.
[0007] At present, after harvesting, Larnia plants are directly processed by farmers at the place of origin. Due to the lack of good processing and processing standards, farmers in various places adopt different processing methods and conditions after harvesting, which leads to heterogeneity. The production (heterogeneousness) seriously affects the biological activity and content of active ingredients in medicinal materials, resulting in unstable quality of medicinal materials in Salvia genus, which is not conducive to the treatment and control of related diseases. For example, see: Production of salvianolic acid B in roots of Salvia miltiorrhiza (Danshen) during the post-harvest drying process.Molecules,2012. 17(3):p.2388-407

Method used

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  • Methods and applications for increasing the content of active ingredients, consistency of chemical composition and/or therapeutic benefits of plants of the genus Larnia
  • Methods and applications for increasing the content of active ingredients, consistency of chemical composition and/or therapeutic benefits of plants of the genus Larnia
  • Methods and applications for increasing the content of active ingredients, consistency of chemical composition and/or therapeutic benefits of plants of the genus Larnia

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1: Effects of Different Processing Methods on the Active Components of Rabbittail Herb

[0094] 1-1. Metabolite analysis

[0095] In order to understand the influence of different processing methods on the harvested herbaceous rabbit tails, firstly, the dried rabbit tails of the group, the shade dried group, and the dried group were tested. 1 H-NMR metabolite analysis, the results are shown in figure 1 and Table 1. Among them, (A) is the drying group, the temperature is 22-28°C; (B) is the shade drying group, the temperature is 22-25°C; (C) is the drying group, the temperature is 40°C; Representative metabolite names are shown in Table 1.

[0096] As shown in Table 1, a total of 33 metabolites were identified in Rabbittail herb, which can be divided into primary and secondary metabolites, and their structures include amino acids, organic acids, sugars, nucleic acids, amines, triterpenoids ( triterpenoids), flavonoids (flavonoids), phenolic acids (phenolic ac...

Embodiment 2

[0119] Example 2: Effects of Different Drying Temperatures on the Active Components of Rabbittail Herb

[0120] 2-1. Metabolite analysis

[0121] The 40°C drying group, 55°C drying group, and 70°C drying group were treated with rabbit tail herbs respectively. 1 H-NMR metabolite analysis, the results are shown in image 3 . Wherein, the stronger the signal, the higher the content.

[0122] like image 3 As shown, compared with the drying group at 55°C or the drying group at 70°C, the content of amino acids, triterpenoids and flavonoids in the drying group at 40°C increased significantly, while the content of sugars decreased significantly.

[0123] 2-2. Metabolome analysis

[0124] Principal component analysis (PCA) was used to analyze the metabolites of the 40°C drying group, 55°C drying group, and 70°C drying group. The results are shown in Figure 4 .

[0125] Depend on Figure 4 It can be seen that the composition of the herbaceous herb in the 40°C drying group is s...

Embodiment 3

[0137] Embodiment 3: the comparison of different batches of Herba Rabbit's Tail Medicinal Materials

[0138] Merge the first batch of sun-dried group, shade-dried group, dried rabbit tail herbal medicine and the second batch of 40℃ dried group, 55℃ dried group, 70℃ dried rabbit tail herbal medicine 1 H-NMR data, and principal component analysis (PCA), in order to intuitively reflect the influence of different factors on the composition of the metabolites of the Herba Larbidis medicinal material, the results are shown in Figure 5 . Among them, the X-axis (PC1 axis, principal component 1) is to analyze different processing factors (including "40 ℃ (represents drying at 40 ℃)" and "non-40 ℃ (not 40 ℃)" shown on the PC1 axis other methods of dry processing)") on the consistency of the chemical composition of Rabbittail herb; the Y-axis (PC2 axis, principal component 2) is the analysis of different batches (including the "first batch" shown on the PC2 axis " and "Second Batch") ...

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Abstract

A method and application for increasing the content of active ingredients, the consistency of the chemical composition of medicinal materials, and / or the therapeutic effect of plants of the genus Larnia, which includes, before performing optional extraction treatment on the harvested plants of the genus Larnia, Carrying out a drying process on the Larnia plant first, so as to increase the active ingredient content, the consistency of the chemical composition of the medicinal material and / or the therapeutic effect of the Larnia plant or its extract, wherein the drying process is carried out in at a temperature of 35 to 45°C.

Description

technical field [0001] The present invention relates to the processing improvement of Larnia plants, wherein the harvested Larnia plants are subjected to a temperature of 35° C. to 45° C. The plant is subjected to a drying process, thereby increasing the content of active ingredients, the consistency of the chemical composition of the medicinal material, and / or the therapeutic benefit of the Larnia genus or its extract. The present invention also relates to the Larnia plant or its extract obtained by the aforementioned processing improvement method. Background technique [0002] Lararia crinita (L.) Desv.ex DC.), Uraria lagopodioides (L.) Desv.ex DC.), Uraria picta (Jacq.) Desv. ex DC.), Uraria neglecta Prain and other Uraria neglecta Prain plants (Uraria spp.) are commonly used to invigorate the spleen and stomach, relieve cough and moisten the throat, remove malnutrition, treat diarrhea, and treat children with dysplasia. , detoxification, swelling and Chinese medicinal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P1/14A61P17/02A61P19/00A61P29/00A61P31/04A61P39/06A61P33/00A61P19/10A61P25/16A61P25/28A61P25/14A61P9/10A61P9/00A61P9/04A61P1/16A61P13/12A61P3/10A61P35/00
CPCA61K36/48A61K2236/17
Inventor 郑皓元赵嵘代云桃李孟修彭文煌鲍力恒郑永齐
Owner CHUNG JEN JUNIOR COLLEGE NURSING HEALTH SCI & MANAGEMENT
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