Reusable light optical fiber electrode as well as making method and embedding method thereof

A manufacturing method and optical fiber technology, applied in applications, veterinary instruments, veterinary surgery, etc., can solve the problems of not being able to be reused, reducing the stability of neuronal activity recording, and expensive optical fiber electrodes

Active Publication Date: 2017-12-22
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

Since one end of the ceramic sleeve is connected to the recording electrode, it will inevitably cause the tip of the recording electrode to shift, thereby reducing the stability of neuron activity recording
(2) The volume is large, so it can only record and control a single brain area in mice, and simply verify the effect of light control, but cannot record and control activities in two or more brain areas at the same time
(3) It is

Method used

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  • Reusable light optical fiber electrode as well as making method and embedding method thereof
  • Reusable light optical fiber electrode as well as making method and embedding method thereof

Examples

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Embodiment Construction

[0040] Embodiments of the technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and therefore are only examples, rather than limiting the protection scope of the present invention.

[0041] It should be noted that, unless otherwise specified, the technical terms or scientific terms used in this application shall have the usual meanings understood by those skilled in the art to which the present invention belongs.

[0042] see Figure 1 to Figure 2 , a reusable portable fiber optic electrode provided in this embodiment, including laser diodes, optical fibers, nerve signal connectors, PCB boards, micro-thrusters, iron sheets, capillary guide tubes, tetrodes, connecting rods, laser diodes It is connected to one end of the optical fiber, the nerve signal connector is welded on the PCB board, the n...

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Abstract

The invention provides a reusable light optical fiber electrode as well as a making method and an embedding method thereof. A laser diode is connected to one end of an optical fiber; a neural signal connector is welded on a PCB; the neural signal connector is electrically connected to the PCB; the PCB is welded on a micro thruster; an iron sheet is perpendicularly fixed to the micro thruster; a capillary guiding tube is stuck on the iron sheet; a tetrode is inserted into the capillary guiding tube; one end of the tetrode protrudes out of the capillary guiding tube and the other end of the tetrode is inserted into a hole of the PCB; a laser diode-optical fiber complex and tetrode electrodes are cured by virtue of glue; one end of a connecting rod is fixed to the micro thruster; and the other end of the connecting rod is fixed to a laser diode base. The laser diode is drawn and controlled by virtue of an extra-fine electric wire, without inserting or removing an optical fiber or an optical fiber sleeve, so that stable multi-channel recording and synchronous multi-modal photic stimulation control can be conducted on two or more encephalic regions of a freely moving mouse easily. The reusable light optical fiber electrode is small in size, light in weight and reusable, so that using cost can be greatly reduced.

Description

technical field [0001] The invention relates to the technical field of optical fiber electrodes, in particular to a reusable portable optical fiber electrode, a manufacturing method and an embedding method thereof. Background technique [0002] Optogenetics is currently the most common method for manipulating the activity of neurons and neural circuits. By coupling with the electrode array and using multi-channel recording technology, the effectiveness of specific wavelength light in controlling neuron activity can be verified in vivo. Existing fiber optic electrodes often have the following disadvantages: (1) Before light stimulation, the optical fiber needs to be inserted into the ceramic sleeve. Since one end of the ceramic sleeve is connected to the recording electrode, it is inevitable that the tip of the recording electrode will be displaced, thereby reducing the stability of neuron activity recording. (2) The volume is large, so it can only record and control a sing...

Claims

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Application Information

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IPC IPC(8): A61B5/0478A61D1/00A61D7/00
CPCA61B5/6868A61B2503/40A61B2503/42A61B2562/0209A61D1/00A61D7/00A61B5/291
Inventor 胡波杨丽
Owner ARMY MEDICAL UNIV
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