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Magnetic doxorubicin albumin nano-particle pressurized vibration wrapping process

A technology of albumin nanoparticles and doxorubicin, which is applied in the directions of organic active ingredients, non-active ingredients of polymer compounds, capsule delivery, etc., can solve the problem that anti-tumor drugs cannot be completely replaced.

Inactive Publication Date: 2017-12-22
锡山区东港全宝机械经营部
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although molecularly targeted drugs have outstanding curative effects on the tumors they target, they are well tolerated and have mild toxicity, but it is generally believed that they cannot completely replace traditional cytotoxic antineoplastic drugs for a long time. More often, a combination of the two

Method used

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  • Magnetic doxorubicin albumin nano-particle pressurized vibration wrapping process

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Embodiment Construction

[0017] 1. Synthesis and characterization of PLA-P85-PLA

[0018] Using Sn(Oct) 2 as a catalyst, polylactic acid (PLA) chains were connected to both ends of Pluronic P85 to prepare PLA-P85-PLA block copolymers. Weigh a certain amount of L-lactide and Pluronic P85, put them into a round-bottomed flask under the condition of argon, heat to make the two substances melt and mix evenly, add a small amount of Sn ( Oct) 2 and carry out vacuum-argon Circulate several times to remove oxygen in the flask, heat the reactant to 160 °C, stir for 15 h, cool to room temperature, add dichloromethane to dissolve the product, sink into 10 times the amount of methanol, and a white substance precipitates out, filter , dissolve the polymer with dichloromethane, sink into 10 times the amount of ether, filter, and dry to obtain the PLA-P85-PLA block copolymer. Take a small amount of PLA-P85-PLA polymer, dissolve it in deuterated chloroform (CDCl3), and measure it by 1 H-NMR. The results are shown in...

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Abstract

The present invention relates to a magnetic doxorubicin albumin nanoparticle pressurized vibration encapsulation process, which includes the following steps: Step 1: uniformly disperse the magnetic doxorubicin albumin nanoparticle powder, and spread it on a flat surface with sufficient surface strength , and on a circular plane surrounded by circles, step 2: Press another flat, smooth and sufficiently hard circular surface on the magnetic doxorubicin albumin nanoparticle powder for pre-pressurization, and the two circular planes The area is equal, and the upper surface is embedded in the lower surface enclosure; Step 3: Then vibrate, pressurize to the required pressure while vibrating, and then drop by drop around the magnetic doxorubicin albumin nanoparticle powder. Solution, just wet it, and keep ventilated at room temperature until the solution evaporates completely.

Description

technical field [0001] The invention relates to a technique of encapsulating magnetic doxorubicin albumin nanoparticles under pressure and vibration. Background technique [0002] The use of molecularly targeted drugs in patients with gastrointestinal tumors can effectively prolong the survival of patients and control the condition of patients. Therefore, the degree of attention in clinical practice is constantly increasing. [0003] Molecular targeted drugs mainly target the key targets of pathophysiological occurrence and development of malignant tumors for therapeutic intervention, and some molecular targeted drugs have shown better efficacy in corresponding tumor treatments. Although molecularly targeted drugs have outstanding curative effects on the tumors they target, they are well tolerated and have mild toxicity, but it is generally believed that they cannot completely replace traditional cytotoxic antineoplastic drugs for a long time. More often, a combination of t...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/42A61K47/34A61K31/704A61P35/00
CPCA61K9/5192A61K9/0009A61K9/5146A61K9/5169A61K31/704
Inventor 王全宝
Owner 锡山区东港全宝机械经营部