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Plant extract for treating ascites, and preparation method of plant extract

A technology for extracts and drugs, applied in the field of medicine, can solve the problems of large side effects of chemotherapy, limited efficacy, lack of treatment methods for cancerous ascites, etc., and achieves the effects of safe and simple operation and high extraction efficiency.

Inactive Publication Date: 2017-12-22
湖南晓林生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] There is no effective treatment for cancerous ascites. The more common treatment methods include intraperitoneal chemotherapy and discharge of ascites, etc., but the curative effect is limited, and the side effects of chemotherapy are relatively large

Method used

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  • Plant extract for treating ascites, and preparation method of plant extract
  • Plant extract for treating ascites, and preparation method of plant extract
  • Plant extract for treating ascites, and preparation method of plant extract

Examples

Experimental program
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Effect test

preparation example Construction

[0043] Preparation of wolfberry extract:

[0044] 1) Dry wolfberry at 55-65°C and crush it to 80-120 meshes, add 5-15 times of water, stir and extract at 45-55°C for 4 hours;

[0045] 2) Remove insoluble matter, use a 0.45 μm filter membrane for primary filtration, and then use a 0.22 μm filter membrane for secondary filtration, collect the obtained filtrate and freeze-dry to obtain a wolfberry extract.

[0046] The above-mentioned Lycium barbarum extract was taken for detection, and the detection results were as follows: Figure 1~3 shown. in, figure 1 It is the absorbance curve of the aqueous solution of wolfberry extract (300mg / mL) at a wavelength of 200nm to 600nm, showing that it has a peak at 283nm, and its absorbance reaches 1.048; figure 2 is the liquid chromatogram of Lycium barbarum extract; image 3 is another liquid chromatogram of Lycium barbarum extract and the mass spectrum of its main peak.

[0047]After testing, every 1000g of wolfberry extract (dry weig...

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Abstract

The invention discloses a plant extract for treating ascites, and a preparation method of the plant extract. The inventor studies for a plurality of years and first finds and confirms that a lycium barbarum extract can be used for locking and selectively treating malignant ascites, thus being expected to become an extremely attractive medicine for treating the malignant ascites. The response rate of a mixture of lycium barbarum alkaloids and lycium barbarum polysaccharides for the malignant ascites reaches 100%, so that the lycium barbarum extract can be used for treating the ascites and ehrlich ascites carcinoma. The possible mechanism of action is to play a role of resisting the malignant ascites by inhibiting cell proliferation, inducing apoptosis and inhibiting angiogenesis. The plant extract provided by the invention has higher targeting ability for the treatment of the malignant ascites, does not generate drug resistance and is free from cross drug resistance with the traditional chemotherapeutic drugs. The lycium barbarum extract is safe and non-toxic, thus being expected to become a new plant medicine for treating the malignant ascites.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a plant extract and a preparation method and application thereof, in particular to a wolfberry extract and a preparation method and application thereof. Background technique [0002] Under normal conditions, there is a small amount of fluid (generally less than 200ml) in the abdominal cavity of the human body, which lubricates the intestinal peristalsis. Any pathological state that leads to an increase in the amount of fluid in the peritoneal cavity, and when it exceeds 200ml, it is called ascites. Ascites is only a symptom. There are many causes of ascites. The more common ones are cardiovascular disease, liver disease, peritoneal disease, kidney disease, nutritional disorder, malignant tumor peritoneal metastasis, ovarian tumor, and connective tissue disease. [0003] Ascites tumor is a tumor characterized by the proliferation of tumor cells in ascites in a floating state. It belongs ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P7/10A61P35/00
CPCA61K36/815A61K2236/331A61K2236/53
Inventor 谢丹
Owner 湖南晓林生物科技发展有限公司
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