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Application of a traditional Chinese medicine composition in the preparation of a medicine for preventing and/or treating hand, foot and mouth disease

A technology of hand, foot and mouth disease and composition, which is applied in the field of medicine, can solve problems such as limiting the scope of application, and achieve the effect of avoiding side effects and overcoming slow curative effect

Active Publication Date: 2021-02-02
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional Chinese medicine composition is composed of forsythia, honeysuckle, ephedra, bitter almond and other medicinal flavors. In the experimental example, the traditional Chinese medicine composition only showed an inhibitory effect on EV 71 virus, which limited its application range.

Method used

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  • Application of a traditional Chinese medicine composition in the preparation of a medicine for preventing and/or treating hand, foot and mouth disease
  • Application of a traditional Chinese medicine composition in the preparation of a medicine for preventing and/or treating hand, foot and mouth disease
  • Application of a traditional Chinese medicine composition in the preparation of a medicine for preventing and/or treating hand, foot and mouth disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024]Example 1. Spray

[0025]prescription:

[0026]

[0027]Preparation Process:

[0028]The two flavors of honeysuckle and parsnip were distilled with water, and 190ml of distilled liquid was collected, and the distilled aqueous solution was filtered and preserved in another device; the medicinal residue and 6 flavors of scutellaria, shegan, shandougen, scrophulariaceae, Ophiopogon and licorice were decocted three times in water, After 2 hours, combine the decoction, filter, combine the filtrate with the above-mentioned aqueous solution, concentrate to 80°C relative density of 1.25, add 70% ethanol to make the alcohol content 78%, stir well, let stand for 15 hours, take the supernatant and filter After the filtrate recovers ethanol, it is concentrated to a clear ointment with a relative density of 1.26 at 75°C; menthol and borneol are dissolved in an appropriate amount of 78% ethanol, and then polysorbate is added to stir evenly, and then slowly added to the above distillate, stirring while ...

Embodiment 2

[0029]Example 2. Tablets

[0030]prescription:

[0031]

[0032]Preparation Process:

[0033]The above twelve flavors, honeysuckle and parsnips are distilled with water, 200ml of distilled liquid is collected, the distilled water solution is filtered, and stored in a separate container; medicinal residues and scutellaria, shegan, mountain bean root, scrophulariaceae, Ophiopogon, licorice 6 flavors add water Decoction three times, 2 hours each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, concentrate to 70°C with a relative density of 1.20, add 60% ethanol to make the alcohol content 70%, stir well, and let stand for 26 hours. Take the supernatant and filter, and recover the ethanol from the filtrate, and concentrate it to a clear cream with a relative density of 1.20 at 70°C. Menthol and borneol are dissolved in 80% ethanol, and then 85ml of polysorbate is added and mixed well, then slowly added to the above distillate, stirring while adding, and the...

Embodiment 3

[0034]Example 3. Capsules

[0035]prescription:

[0036]

[0037]Preparation Process:

[0038]The above twelve flavors, honeysuckle and parsnips are distilled with water, 200ml of distilled liquid is collected, the distilled water solution is filtered, and stored in a separate container; medicinal residues and scutellaria, shegan, mountain bean root, scrophulariaceae, Ophiopogon, licorice 6 flavors add water Decoction three times, 2 hours each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, concentrate to 70°C with a relative density of 1.20, add 60% ethanol to make the alcohol content 70%, stir well, and let stand for 26 hours. Take the supernatant and filter, and recover the ethanol from the filtrate, and concentrate it to a clear cream with a relative density of 1.20 at 70°C. Menthol and borneol are dissolved by adding an appropriate amount of 80% 7% alcohol, and then 85ml of polysorbate is added and mixed well, then slowly added to the above distil...

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PUM

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to the application of a traditional Chinese medicine composition in the preparation of medicines for preventing and / or treating hand, foot and mouth disease. The traditional Chinese medicine composition is made from the following raw materials: watermelon Cream 20‑60 parts by weight, Scutellaria baicalensis 75‑220 parts by weight, Shegan 75‑220 parts by weight, Bean root 50‑150 parts by weight, Honeysuckle 80‑240 parts by weight, Fangfeng 40‑120 parts by weight, Menthol 1‑4 parts by weight 1-4 parts by weight of borneol, 10-50 parts by weight of borax, 40-120 parts by weight of Radix Scrophulariae, 40-120 parts by weight of Ophiopogon japonicus, 40-120 parts by weight of Radix Glycyrrhizae, the Chinese medicine composition is effective for EV71 and / or Cox A16 The virus has a certain inhibitory effect in vitro, which provides a basis for its application in hand, foot and mouth disease. The Chinese medicine composition of the invention avoids some side effects of western medicine, and overcomes the defect of slow curative effect of traditional Chinese medicine.

Description

Technical field[0001]The invention belongs to the technical field of medicine, and specifically relates to the application of a traditional Chinese medicine composition in the preparation of a medicine for preventing and / or treating hand, foot and mouth disease.Background technique[0002]Hand, foot and mouth disease is an infectious disease caused by enteroviruses. There are more than 20 types of enteroviruses that cause hand, foot and mouth disease, including Coxsackie virus A16 (Cox A16) and enterovirus 71 (EV 71). ) Is the most common. After the virus invades the human body through the oropharynx, it first binds to the membrane protein receptor of the host oropharynx to the mucosal epithelial cell membrane of the lower digestive tract, implants into the host cell and removes the capsid, releases RNA into the host cell for transcription , Replication and proliferation. Subsequently, the virus transfers from the primary lesion through the lymphatic channels to the local lymphatic ti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K9/12A61P31/14A61K33/22A61K31/045
Inventor 邹节明
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD