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An application of cystine in preparation of a medicine for reducing hepatotoxicity caused by adriamycin

A liver toxicity, doxorubicin technology, applied in the field of medicine, can solve problems such as hair loss, liver and kidney function damage

Inactive Publication Date: 2018-01-09
CHINA PHARM UNIV
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Problems solved by technology

However, clinical reports have shown that adverse reactions such as cardiotoxicity, bone marrow suppression, liver and kidney function damage, gastrointestinal reactions, and hair loss often occur in patients receiving doxorubicin chemotherapy.
There is no report that cystine can effectively reverse the hepatotoxicity of tumor chemotherapy drugs

Method used

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  • An application of cystine in preparation of a medicine for reducing hepatotoxicity caused by adriamycin
  • An application of cystine in preparation of a medicine for reducing hepatotoxicity caused by adriamycin

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Embodiment Construction

[0008] The present invention is explained in detail by the following examples, but it does not mean that the present invention is limited thereto.

[0009] Cell source and culture: human breast cancer doxorubicin-resistant cell line MCF-7 / ADR was purchased from Tianjin Institute of Hematology, Chinese Academy of Medical Sciences (Tianjin, China), and the cells were cultured at 37°C with 5% CO 2 In the environment, the culture medium is RPMI1640 medium, containing 10% fetal bovine serum (FBS), and streptomycin 100mg / L, penicillin 62.5mg / L. The cells were grown in a 10 cm culture dish, and the medium was changed once every 2-3 days, and the cells were passaged when the cells grew to 90% confluence.

[0010] Source and feeding of animals: Balb / c-nu / nu mice (female, provided by the Institute of Model Animals, Nanjing University, aged 4-6 weeks, weighing 20±2g) were used for experiments. Under the standard feeding environment (eating and drinking freely, alternation of day and nig...

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Abstract

An application of cystine in preparation of a medicine for reducing hepatotoxicity caused by adriamycin is disclosed. Through building a human-derived breast cancer cell MCF-7 / ADR tumor-bearing mousemodel, and through dosing mice with adriamycin and cystine separately and dosing mice with the adriamycin and cystine in combination, results show that the cystine can effectively improve hepatic celllesion and necrocytosis caused by the adriamycin, and can significantly reduce contents of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum of mice affected with liver injury caused by the adriamycin. The cystine can be used in combination to reverse hepatotoxicity of the adriamycin, can improve liver functions, and can be applied as a liver protecting agent for the adriamycin that is an antitumor medicine.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new application of cystine, that is, the application of cystine in the preparation of drugs for reducing liver toxicity caused by doxorubicin. Background technique [0002] Doxorubicin (adriamycin, ADR or doxorubicin, DOX) is the first anthraquinone antibiotic isolated from the glycolysis product of mutant Streptomyces peucetius by Italian scientists in 1969, which can inhibit RNA and DNA Synthetic, so as to produce curative effect on a variety of tumors, is a cycle non-specific drug, and has a strong killing effect on tumor cells of various growth cycles. Since the drug was used in the clinical treatment of cancer, it is considered to be an efficient and broad-spectrum anticancer drug for the treatment of solid tumors, and is widely used in the treatment of leukemia, malignant lymphoma, breast cancer, lung cancer, etc. However, clinical reports have shown that adverse reactions such as c...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K31/704A61P1/16A61P35/00
Inventor 王广基阿基业冯冬
Owner CHINA PHARM UNIV
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