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Preservative for externally-applied dermal preparation, and cosmetic composition and pharmaceutical composition each containing same

A technology for cosmetic compositions and external preparations for skin, applied in the directions of cosmetics, cosmetic preparations, preparations for skin care, etc., can solve problems such as limited application, and achieve the effects of excellent preservation ability, improved preservation ability and safety.

Inactive Publication Date: 2018-01-16
ACTIVON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, only the synergistic antibacterial effect of the combination of 4-hydroxyacetophenone, which is an acetophenone derivative, and 1,2-hexanediol, which is an alkanediol, is actually described in the specification.
In addition, the above-mentioned combination of 4-hydroxyacetophenone and 1,2-hexanediol was prepared as a solvable form with water as the main solvent, and crystals were sucked out, so there was a problem that the application as a solvable form in the field of cosmetics was limited.

Method used

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  • Preservative for externally-applied dermal preparation, and cosmetic composition and pharmaceutical composition each containing same
  • Preservative for externally-applied dermal preparation, and cosmetic composition and pharmaceutical composition each containing same
  • Preservative for externally-applied dermal preparation, and cosmetic composition and pharmaceutical composition each containing same

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0067] Specifically, the preparation method of the external skin preparation can directly apply the above-mentioned description of the preservative for external skin preparation, cosmetic composition and pharmaceutical composition for external skin preparation according to an embodiment of the present invention.

[0068] In a specific example, the external skin preparation is a cosmetic composition or a pharmaceutical composition for external skin preparations.

[0069] The content of the preservative for external skin preparations may be about 0.01 to 20% by weight relative to the cosmetic composition or the pharmaceutical composition for external skin preparations.

experiment example 3

[0171] Experimental example 3: Preservative preparation and skin irritation test

[0172] In order to confirm whether or not to irritate the skin, preservatives for skin external preparations were prepared according to the composition shown in Table 21 below (unit: weight %).

[0173] The patch was attached to the upper back of the subject, and 25% preservative 20 Perform a patch test. The first reading was performed 30 minutes after the patch was removed, and the second reading was performed 24 hours later. In order to confirm the irritation intensity of each preservative to the skin, a weighted value was given according to the degree of positive skin reaction, and the primary skin irritation index (Primary Cutaneous Irriation index.P.C.I) was calculated according to the following formula 1 to judge the skin irritation of the sample.

[0174] The results are shown in Table 21 below.

[0175] [Formula 1]

[0176] Primary skin irritation index=∑Grade of each subject / Numb...

experiment example 4

[0181] Experimental Example 4: Sensory Test

[0182] Take 20 subjects as objects, and randomly wipe the 15ml wet tissue dosage forms of the above-mentioned embodiments 15-16 and comparative examples 19 and 21 on the sides of the nose and left and right cheeks of the face, according to the evaluation criteria in the following table 22. The stimulation sensations of "stinging pain" and "hotness" were evaluated, and the results are shown in Table 22.

[0183] [Table 22]

[0184] Fraction

0-0.39

0.4-1.0

1.1-2.0

2.1-3.0

excitement

No

little

generally

serious

[0185] [Table 23]

[0186]

[0187]

[0188] As shown in Table 23 above, according to a specific example of the present invention, the dosage forms of Examples 15 and 16 have irritations such as stinging pain and hotness that are at least 1 / 5 of those of the dosage forms of Comparative Examples 19 and 21, thus confirming that they can Safe for use on skin.

[0189] ...

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Abstract

An aspect of the present invention provides: a preservative for an externally-applied dermal preparation, the preservative comprising an acetophenone derivative of chemical formula 1 and dipropyleneglycol; and a cosmetic composition and a pharmaceutical composition for an externally-applied dermal preparation, the compositions each comprising the preservative for an externally-applied dermal preparation.

Description

technical field [0001] The present invention relates to a preservative for skin external preparations and a cosmetic composition and a pharmaceutical composition containing the same. A novel preservative for external skin preparations that is safe against the toxicity, skin irritation, and allergies of preservatives such as esters, and a cosmetic composition and a pharmaceutical composition containing the preservative. Background technique [0002] Cosmetic compositions and pharmaceutical compositions for external skin preparations cannot avoid contamination caused by microorganisms during the preparation process and use, so preservatives are used to improve the preservation of products. Preservatives such as paraben-based preservatives (sodium paraben), imidazolidinyl urea, and phenoxyethanol are widely used as such preservatives. These preservatives have high antimicrobial activity and excellent preservation ability, but are known to frequently induce toxicity, skin irrit...

Claims

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Application Information

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IPC IPC(8): A61K8/35A61K8/34A61K31/12A61K31/045A61K8/02A61Q19/00A61K9/06A61K9/70
CPCA61K8/02A61K8/34A61K8/35A61K9/06A61K9/70A61K31/045A61K31/12A61Q19/00
Inventor 曹润基杨汉龙曹明赞
Owner ACTIVON
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