Nanostructured bactericidal composite drug, and preparation method thereof
A nanostructure and drug technology, applied in pharmaceutical formulations, antibacterial drugs, preparations for in vivo tests, etc., can solve the problems of inability to achieve location tracking and precise administration of bactericidal drugs, and achieve the effect of synergistic effect of bactericidal properties
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Embodiment 1
[0040] (1) Add silver nitrate solution (5mL, 20mM) and glutathione (5mL, 50mM) into 6mLs water, stir well to form GSH-Ag + complex, then add 3mL sodium borohydride aqueous solution, let it stand for 18 hours to obtain sub-nanometer silver clusters, and finally stir the silver clusters (0.5mL, 100μg / mL) with daptomycin for 8 hours, take them out and spin at 11000 rpm After 20 minutes of centrifugation for 20 minutes, the subnano-silver cluster A of surface-grafted drug molecules was obtained;
[0041] (2) Thoroughly stir chloroauric acid (5mL, 0.5mM) and CTAB (5mL, 0.2M) until evenly mixed, then add sodium borohydride (0.6mL, 0.01mM) to obtain gold nuclei, then take 1mL of the above solution and add it to CTAB-stabilized gold nanorods B were obtained by standing in 500 mL growth solution containing chloroauric acid (250 mL, 1 mM) and CTAB (9 g) for 12 h;
[0042] (3) Add the above-synthesized silver cluster A (0.5mL, 100μg / mL) and gold nanorod B (0.5mL, 1mg / mL) into 5mL of wat...
Embodiment 2
[0045] (1) Add silver acetate solution (6mL, 20mM) and glutathione (5mL, 50mM) into 6mLs water, stir well to form GSH-Ag + Complex, then add 3mL sodium borohydride aqueous solution, let it stand for 18 hours to obtain sub-nanometer silver clusters, and finally stir the silver clusters (0.6mL, 100μg / mL) with oxacillin for 8 hours, take them out and turn them at 11000 rpm After centrifugation for 20 minutes, the subnano-silver cluster A with drug molecules grafted on the surface is obtained;
[0046] (2) Thoroughly stir chloroauric acid (5mL, 0.5mM) and PSS (5mL, 0.2M) until evenly mixed, then add sodium borohydride (0.6mL, 0.01mM) to obtain gold nuclei, then take 1mL of the above solution and add it to PSS-stabilized gold nanorods B were obtained by standing in 500 mL growth solution containing chloroauric acid (250 mL, 1 mM) and PSS (18 g) for 12 h;
[0047] (3) Add the above-synthesized silver cluster A (0.6mL, 100μg / mL) and gold nanorod B (0.6mL, 1mg / mL) into 5mL of water a...
Embodiment 3
[0050] (1) Add silver oxalate solution (10mL, 20mM) and glutathione (5mL, 50 mM) into 6mLs water, stir well to form GSH-Ag + Complex, then add 6mL sodium borohydride aqueous solution, let it stand for 18 hours to obtain sub-nanometer silver clusters, and finally stir the silver clusters (0.6mL, 100μg / mL) with oxacillin for 8 hours, take them out and turn them at 11000 rpm After centrifugation for 20 minutes, the subnano-silver cluster A with drug molecules grafted on the surface is obtained;
[0051] (2) Thoroughly stir gold trichloride (4mL, 0.8mM) and PEG (5mL, 0.2M) until evenly mixed, then add sodium borohydride (0.6mL, 0.01mM) to obtain gold nuclei, then take 1mL of the above solution and add Put into a 500mL growth solution containing gold trichloride (100mL, 2.5mM) and PEG (18g) and let it stand for 12h to obtain PEG-stabilized gold nanorods B;
[0052] (3) Add the above-synthesized silver cluster A (0.8mL, 50μg / mL) and gold nanorod B (0.8mL, 1mg / mL) into 5mL of water ...
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