A kind of n-octadecyl ethyl imidate methyl ester and its synthetic method

Abstract

The invention provides N-octadecyl methyl ethylamine and a synthesis method thereof. The synthesis method comprises the following steps: dissolving acetal and octadecylamine into methanol, wherein themolar ratio of the acetal to the octadecylamine ranges from1:1 to 1.5:1, and the weight of the methanol is 50 to 99 percent of the total weight; heating to appointed temperature and performing normal-pressure reaction for 0.1 to 12 hours; reducing the pressure to 0.01 to 0.08 MPa, carrying out a reaction at 20 to 120 DEG C for 0.25 to 12 hours, and stopping the reaction to obtain the N-octadecylmethyl ethylamine. The yield of the N-octadecyl methyl ethylamine synthesized by the synthesis method of the N-octadecyl methyl ethylamine can reach up to 71 percent or higher, the synthesis method issimple in operation, the volatile products are easy to recover, and environmental friendliness is achieved.

Description

technical field [0001] The invention relates to a synthesis method, in particular to a synthesis method of methyl N-octadecyl acetimidate, which belongs to the technical field of organic synthesis. Background technique [0002] N-substituted imidate is an important class of organic synthesis intermediates, and is also an important raw material for pharmaceutical research and development. The main intermediates of compounds such as (PataiS, Rappoport Z. The Chemistry of amidines and imidates [M]. Wiley, 1975). [0003] At present, the synthesis of N-substituted imidate compounds includes: [0004] Pinner reaction: under the catalysis of acid (such as hydrochloric acid), nitrile and alcohol generate imidate hydrochloric acid, which reacts with amine to generate N-substituted imidate compound (Jiang Hu, Liu Yin, Liu Xiaole, etc. N-cyanide A new method for the synthesis of ethyl ethyl imidate [J]. Applied Chemical Industry, 2013, 42(2): 274-278). [0005] [0006] Alkylati...

AI Technical Summary

Problems solved by technology

In the unsaturated system synthesis method and the triethyl orthoformate method, the imidate yield is low; while the Schmidt reaction process is complicated and the operation is cumbersome

[0014] And, the synthetic method of above N-substituted imidate is mainly limited to the target product of the functional group of short carbon chain, and for the imidic acid methyl ester of long carbon chain such as N-octadecyl ethyl imidic acid methyl ester The production method has not been reported in the public literature so far

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