Long-acting controlled release composite film with gel-state pressure transmission control layer and preparation method of long-acting controlled release composite film

Abstract

The invention relates to the technical field of medical composite films, in particular to a long-acting controlled release composite film with a gel-state pressure transmission control layer. The long-acting controlled release composite film comprises a controlled release composite support and a microchannel transmission layer arranged at the bottom of the controlled release composite support, wherein the controlled release composite support is sequentially divided into an interpenetrating network micro-scaffold structure layer, a swelling microgel pressure transmission control layer and a restrictive pressure transmission control layer which are arranged from the inside out. A preparation method of the long-acting controlled release composite film comprises the following steps: preparation of a swelling pressure control microgel, preparation of a swelling pressure control microgel, liquid viscosity improving and structural strengthening of the microgel, preparation of an interpenetrating structural body, immobilization of the interpenetrating structural body, packaging of a pressure control tank, and procedure simplification. The preparation method is suitable for continuous automatic manufacture; the characteristics of air permeability, moisture permeability and the like ensure that a wound is in a favorable cell growing and healing environment; and besides, as a dressing istransparent, the wound healing situation can be favorably observed directly, and accordingly, the wound therapy condition can be controlled.

Description

technical field [0001] The invention relates to the technical field of medical composite membranes, in particular to a long-acting controlled-release composite membrane with a gel-state pressure transmission control layer and a preparation method thereof. Background technique [0002] The drug controlled release is to release the drug quantitatively and uniformly through the controlled release coating to keep the blood drug concentration constant. The function of drug controlled release can be achieved through the membrane through the control system and the body diffusion system. It is implemented by means of biological understanding mechanism, through mechanism, and in vitro control. The controlled release of existing composite membranes containing pharmaceutical excipients is relatively difficult and cannot meet daily medical needs. In the known gel manufacturing process, the reaction mixture solution used to form the gel will be in a solution state before the polymerizati...

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Problems solved by technology

[0003] In order to overcome the shortcomings of the existing drug-loaded composite membranes that are difficult to control release, the present invention provides a long-acting controlled-release composite membrane with a gel state pressure transmission control layer and its preparation method

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