Double-excitation fluorescence probe preparation and application in detection of hydrazine in water

A fluorescent probe, fluorescein technology, applied in the field of analytical chemistry, can solve problems such as liver central nervous system damage, and achieve the effect of low cost
CN107699233AActive Publication Date: 2018-02-16LIAONING UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LIAONING UNIVERSITY
Publication Date
2018-02-16

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Abstract

The invention discloses a double-excitation fluorescence probe and a preparation method and application thereof in detection of hydrazine in water. The preparation method includes: taking diethylenetriamine pentaacetic acid, acetic anhydride and pyridine, stirring and heating for 24h at 65 DEG C, cooling, filtering, washing and drying; well mixing obtained diethylenetriamine pentaacetic acid dianhydride with triethylamine, DMF (dimethyl formamide) and fluorescein, heating and stirring for 24h at a constant temperature of 100 DEG C, cooling, filtering, and drying; dissolving obtained diethylenetriamine pentaacetic acid-bis(fluorescein) into Tris-HCl / DMSO (10mmol.L<-1>, v / v=9:1) buffer solution with pH equal to 7.5, mixing with Tb(NO3)3.6H2O, and heating or placing for more than two hours toobtain a target product. Uric acid detection is realized by combination of Tb<3+>-dtpa-bis(fluorescein) as a double-excitation probe and a fluorescence method. The method is simple, novel, high in efficiency and low in cost, and applicability to practical water samples is realized.
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Description

technical field

[0001] The invention belongs to the field of analytical chemistry, in particular to the synthesis of novel fluorescent probes and the detection of hydrazine. Background technique

[0002] Hydrazine is an important industrial raw material and should be widely used in the fields of agriculture, medicine and chemistry. Because of its flammable and explosive properties, hydrazine is also a familiar high-energy fuel used in rocket propellants. From the chemical structure point of view, hydrazine has two functional groups, and both can show nucleophilic properties, which makes hydrazine can synthesize many derivative products, such as antidiabetic drugs, anti-tuberculosis drugs, plant growth regulators, herbicides, slow etchants and dyes. More recently, a common hydrazine derivative has also been discovered, such as hydralazine, which is used in the treatment of heart failure and high blood pressure. Despite its wide range of applications, we should be highly aw...

Claims

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