Antibacterial gel containing iodine tincture, and preparation method thereof

Abstract

The invention discloses an antibacterial gel containing iodine tincture, and a preparation method thereof, wherein the antibacterial gel containing iodine tincture comprises, by mass, 0.5-10% of iodine tincture, 0.1-3% of a polymer thickener, 0.1-5% of a chitosan or chitin derivative, 0.05-2% of a zinc salt, 10-75% of alcohol, and 20-80% of pure water. According to the present invention, by complexing iodine tincture and the chitosan / chitin derivative, the iodine molecule is embedded into the axial center position of the spiral body of the chitosan / chitin derivative to form the slight yellow or colorless transparent inclusion compound, such that the iodine in the system can stably exist in the gel, the wound surface can be protected after the antibacterial gel is coated and forms the film,the antibacterial / sterilization effect can be continuously provided, the chitosan / chitin derivative can promote the wound healing so as to provide a good wound healing environment, the irritation andthe corrosion of the product can be effectively reduced, the yellowing can be avoided, and deiodination is not required after the use; and the antibacterial gel can strongly inhibit Escherichia coli,Staphylococcus aureus, Candida albicans and other pathogenic bacteria, can be used for antibacterial / bacterial inhibition of bacteria and fungi, and can further be used for providing antibacterial effects on mosquito bites, skin itching, red swelling of skin, acne and other conditions.

Description

technical field [0001] The invention relates to a bacteriostatic agent and a preparation method thereof, in particular to a bacteriostatic gel containing iodine tincture and a preparation method thereof. Background technique [0002] Iodine tincture, also known as iodine wine, is a well-known bactericidal disinfectant, which can efficiently kill bacteria, spores, protozoa, molds, fungi, viruses and other pathogenic bacteria that infect the skin. group, and combine with the amino group of the protein to denature it, so that the enzyme protein is oxidized and inactivated. Acting directly on the affected area, iodide ions can quickly destroy pathogenic bacteria, gradually shrink the affected area, cause necrotic tissue to fall off, and collagen fiber cells to proliferate and repair the skin. [0003] Iodine tincture has the disadvantages of strong irritation, strong corrosiveness, need alcohol deiodination, instability, and the skin is yellow and ugly after application, and it...

AI Technical Summary

Problems solved by technology

[0006] Although povidone iodine has less volatility, better water solubility, relatively less irritation and is easier to wash off than iodine tincture, there are still some shortcomings that need to be improved. For example, povidone iodine is a reddish-brown liquid, and it will dissolve Skin staining, prone to pigmentation; although its irritation is lighter than that of iodine tincture, it can still cause allergic reactions and irritation to the skin and mucous membranes. External application to pregnant women, nursing mothers and infants can cause obvious absorption of iodine, local irritation and burning sensation; Povidone-iodine has the effect of dehydrating the tissue, leading to dryness of the wound surface, which is not conducive to wound healing; povidone-iodine is unstable under light and heat, and needs to be stored away from light; povidone-iodine is still corrosive to a certain extent, and metal products can cause corrosion

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