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Composite electrolyte injection

A compound electrolyte and injection technology, applied in the field of chemical medicine, can solve problems such as unfavorable use of blood sugar, unstable pH value of injection, etc., and achieve the effect of promoting intestinal movement, increasing liver burden, and simple preparation method

Inactive Publication Date: 2018-03-06
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a compound electrolyte injection containing a buffering agent, which solves the problems in the prior art that the pH value of the injection is unstable and unfavorable for those with high blood sugar

Method used

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  • Composite electrolyte injection

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation formula of compound electrolyte injection containing buffer is as follows:

[0031] Sodium chloride 0.53g;

[0032] Sodium gluconate 0.5g;

[0033] Sodium acetate (trihydrate) 0.37g;

[0034] Potassium chloride 0.037g;

[0035] Magnesium chloride (hexahydrate) 0.03g;

[0036] Disodium hydrogen phosphate (heptahydrate) 0.010g;

[0037] Potassium dihydrogen phosphate 0.00086g;

[0038] Glucose 1.3g;

[0039] Fructo-oligosaccharide 1.0g;

[0040] Appropriate amount of glacial acetic acid or sodium hydroxide;

[0041] The water for injection is about 100mL, the osmotic pressure is 280-300mOsmol / L, and the pH value is 7.0-7.8.

[0042] The preparation method is as follows

[0043] (1) Concentrated

[0044] 1. Add about 50% volume of fresh water for injection at 50°C to 70°C into the preparation container, and start stirring;

[0045] 2. Add potassium dihydrogen phosphate and disodium hydrogen phosphate, stir for 10-15 minutes until completely disso...

Embodiment 2

[0055] The preparation formula of compound electrolyte injection containing buffer is as follows:

[0056] Sodium chloride 0.53g;

[0057] Sodium gluconate 0.5g;

[0058] Sodium acetate (trihydrate) 0.37g;

[0059] Potassium chloride 0.037g;

[0060] Magnesium chloride (hexahydrate) 0.03g;

[0061] Disodium hydrogen phosphate (heptahydrate) 0.012g;

[0062] Potassium dihydrogen phosphate 0.00082g;

[0063] Glucose 1.2g;

[0064]Fructose-oligosaccharide 1.2g, fructo-oligosaccharide is currently used in food sweeteners and is not easily absorbed by the human body;

[0065] Appropriate amount of glacial acetic acid or sodium hydroxide;

[0066] The water for injection is about 100mL, the osmotic pressure is 280-300mOsmol / L, and the pH value is 7.0-7.8.

[0067] The preparation method is as follows

[0068] (1) Concentrated blend:

[0069] 1. Add about 50% volume of fresh water for injection at 50°C to 70°C into the preparation container, and start stirring;

[0070] 2....

Embodiment 3

[0079] The preparation formula of compound electrolyte injection containing buffer is as follows:

[0080] Sodium chloride 0.53g;

[0081] Sodium gluconate 0.5g;

[0082] Sodium acetate (trihydrate) 0.37g;

[0083] Potassium chloride 0.037g;

[0084] Magnesium chloride (hexahydrate) 0.03g;

[0085] Disodium hydrogen phosphate (heptahydrate) 0.020g;

[0086] Potassium dihydrogen phosphate 0.00089g;

[0087] Glucose 1.4g;

[0088] fructo-oligosaccharide 0.8g;

[0089] Appropriate amount of glacial acetic acid or sodium hydroxide;

[0090] The water for injection is about 100mL, the osmotic pressure is 280-300mOsmol / L, and the pH value is 7.0-7.8.

[0091] The preparation method is as follows

[0092] (1) Concentrated preparation: 1. Add about 50% volume of fresh water for injection at 50°C to 70°C into the preparation container, and start stirring;

[0093] 2. Add potassium dihydrogen phosphate and disodium hydrogen phosphate, stir for 10-15 minutes until completely di...

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Abstract

The invention provides a composite electrolyte injection with a buffer agent and relates to the field of chemical medicines. Every 100ml of the injection comprises 0.037g of potassium chloride, 0.53gof sodium chloride, 0.5g of sodium gluconate, 0.03g of magnesium chloride, 1.5-1.2g of glucose, 0.8-1.2g of fructo-oligose, a pH value buffer agent and a pH value adjusting agent, wherein the pH valuebuffer agent is acetate and is preferably selected from sodium hydrogen phosphate (heptahydrate) and monopotassium phosphate; the concentration of the sodium hydrogen phosphate (heptahydrate) is 0.1-0.2g / L; the concentration of the monopotassium phosphate is 8.0-9.0mg / L; and the pH value adjusting agent is at least one of glacial acetic acid and sodium hydroxide. The composite electrolyte injection has the beneficial effects that saccharides are replenished, intestinal flora are regulated, patients in transfusion are prevented from constipation, no extra burden is caused, the pH value of theinjection is maintained within 7.0-7.8, and pH value adjusting procedures of the injection are simplified.

Description

technical field [0001] The invention provides a compound electrolyte injection and relates to the technical field of chemistry and medicine. Background technique [0002] Disorders of water and electrolyte metabolism are relatively common clinically. Diseases of many organ systems, such as liver cirrhosis, diabetes, pulmonary heart disease, burns, and post-operation, can cause or be accompanied by disturbances of water and electrolyte metabolism. 1. Electrolyte metabolism disorder can cause corresponding obstacles in the physiological functions of various organ systems, especially the cardiovascular system and nervous system, and the body's substance metabolism. In severe cases, it can lead to death. The use of electrolyte injection can correct the water and electrolyte metabolism in the patient's body. disorder, maintain body fluid osmotic pressure and restore normal physiological functions of the human body. [0003] At present, the commonly used drugs for replenishing an...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61P7/08A61K33/06A61K31/191A61K31/19A61K31/7004A61K31/702A61K31/733
CPCA61K9/0019A61K9/08A61K31/19A61K31/191A61K31/7004A61K31/702A61K31/733A61K33/06A61K33/14A61K47/02A61K2300/00
Inventor 冯新光宋群李继仁
Owner HUAREN PHARMACEUTICAL CO LTD
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