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Carrier composition of nuclein, preparation method of carrier composition, liquid embolism agent, using method of liquid embolism agent and nuclein mixture

A technology of liquid embolism and composition, which is applied in the field of medical supplies, can solve the problems of liver cancer patients being unsuitable, and achieve the effects of simple preparation method, large application time window, and reduced toxicity

Inactive Publication Date: 2018-03-06
杭州华微医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So DMSO is not suitable for embolization of peripheral blood vessels
Moreover, the vascular toxicity of DMSO is very unsuitable for liver cancer patients with poor liver function.

Method used

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  • Carrier composition of nuclein, preparation method of carrier composition, liquid embolism agent, using method of liquid embolism agent and nuclein mixture
  • Carrier composition of nuclein, preparation method of carrier composition, liquid embolism agent, using method of liquid embolism agent and nuclein mixture

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Embodiment Construction

[0024] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0025] The present invention proposes a nuclide carrier composition, comprising polyethylene-vinyl alcohol copolymer (EVOH polymer), and N-formazol for miscibility with the polyethylene-vinyl alcohol copolymer (EVOH polymer). base pyrrolidone.

[0026] In the embodiment of the present invention, the nuclide carrier composition includes polyethylene-vinyl alcohol copolymer (EVOH polymer), and a mixed solvent of dimethyl sulfoxide (DMSO) and N-methylpyrrolidone. The addition of the N-methylpyrrolidone reduces the toxicity of the carrier composition of the nuclide. Further, using the N-methylpyrrolidone to completely replace the dimethyl sulfoxide (DMSO) can minimize the toxicity of the carrier composition of the nuclide.

[0027] Specifically, in the mixed solvent of the dimethyl sulfoxide (DMSO) and N-methylpyrrolidone, the higher the proportion of the...

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Abstract

The invention discloses a carrier composition of nuclein, a preparation method of the carrier composition, a liquid embolism agent, a using method of the liquid embolism agent and a nuclein mixture. The carrier composition of nuclein comprises a polyethylene-vinyl alcohol copolymer (an EVOH polymer), and N-methyl pyrrolidone used for being mutually dissolved with the polyethylene-vinyl alcohol copolymer (the EVOH polymer). A mixed solvent is formed by mutually dissolving the solvent N-methyl pyrrolidone and the polyethylene-vinyl alcohol copolymer (the EVOH polymer) and can be prepared into the liquid embolism agent to be used for loading the nuclein. Since dimethyl sulfoxide (DMSO) is replaced with the N-methyl pyrrolidone, the toxicity is reduced, the preparation method is simple, and the application time window is wide.

Description

technical field [0001] The invention relates to the field of medical supplies, in particular to a nuclide carrier composition and a preparation method, a liquid embolic agent and a use method, and a nuclide mixture. Background technique [0002] Primary liver cancer is a common malignant tumor, and its treatment effect, especially for advanced liver cancer, is still unsatisfactory. Transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) are the most important treatment methods for the treatment of advanced liver cancer. [0003] Liver cancer tissue is mainly supplied with nutrients by arteries, while normal liver tissue is supplied with nutrients by portal vein. Tumors can be treated by selectively embolizing the hepatic artery with drugs. This is transarterial chemoembolization (TACE). TACE combines selective arterial embolization with the injection of chemotherapy drugs. By using drug-eluting microspheres, patient tolerance is improved. The m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00A61K51/06A61P35/00A61K103/32
CPCA61K51/06A61L24/001A61L24/0015A61L24/06A61L2300/44A61L2300/802C08L23/0861
Inventor 徐平
Owner 杭州华微医疗科技有限公司