Hydrogel and application thereof

A hydrogel and catalyst technology, applied in the hydrogel and its application fields, can solve the problems of high hardness, not easy to bend and deform, poor biocompatibility, and high lumen blockage rate, and achieves that it is not easy to fall off, is easy to modify, and has a long life. Implantation Cycle Effects

Active Publication Date: 2018-03-13
广州锐澄医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the common artificial nasolacrimal duct stents are mainly made of the following materials: (1) Metal materials: mostly made of alloys, with good supporting effect, but high hardness, not easy to bend and deform, high lumen blockage rate, and many complications , which is rarely used at present; (2) glass: good supporting effect, but obvious foreig

Method used

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  • Hydrogel and application thereof
  • Hydrogel and application thereof

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Embodiment 1

[0023] One embodiment of the hydrogel of the present invention comprises the following preparation raw materials in parts by weight: 40 parts of hydroxyethyl methacrylate, 20 parts of crosslinking agent, 40 parts of water, 5 parts of thermal initiator and 10 parts of catalyst;

[0024] Wherein, the crosslinking agent is polyethylene glycol diacrylate, the thermal initiator is azobisisobutyronitrile, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0025] An artificial nasolacrimal duct comprising the hydrogel described in this embodiment.

Embodiment 2

[0027] An embodiment of the hydrogel of the present invention, the difference between the hydrogel of this embodiment and Example 1 is that the ratio of the thermal initiator and the catalyst is different, and the hydrogel of the present embodiment contains the following weight Parts of raw materials for preparation: 40 parts of hydroxyethyl methacrylate, 20 parts of crosslinking agent, 40 parts of water, 5 parts of thermal initiator and 5 parts of catalyst;

[0028] Wherein, the crosslinking agent is polyethylene glycol diacrylate, the thermal initiator is azobisisobutyronitrile, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0029] An artificial nasolacrimal duct comprising the hydrogel described in this embodiment.

Embodiment 3

[0031] An embodiment of the hydrogel of the present invention, the difference between the hydrogel of this embodiment and Example 1 is that the ratio of the thermal initiator and the catalyst is different, and the hydrogel of the present embodiment contains the following weight Parts of raw materials for preparation: 40 parts of hydroxyethyl methacrylate, 20 parts of crosslinking agent, 40 parts of water, 5 parts of thermal initiator and 15 parts of catalyst;

[0032] Wherein, the crosslinking agent is polyethylene glycol diacrylate, the thermal initiator is azobisisobutyronitrile, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0033] An artificial nasolacrimal duct comprising the hydrogel described in this embodiment.

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Abstract

The invention discloses hydrogel. The hydrogel comprises the following preparation raw materials in parts by weight: 10 to 80 parts of hydroxyethyl methylacrylate, 1 to 20 parts of a crosslinking agent, 10 to 80 parts of water and 0.042 to 36 parts of a reaction releaser, wherein the crosslinking agent is at least one of polyethylene glycol diacrylate, ethylene glycol dimethacrylate and isocyanuric acid triallyl ester; and the reaction releaser is a mixture of a thermal initiator and a catalyst or a photoinitiator. The hydrogel has high hydrophilic performance, has high mechanical property andhas high biocompatibility and stability in a human body. The invention also provides an artificial nasolacrimal duct containing the hydrogel. The artificial nasolacrimal duct has high tear guide efficiency, high biocompatibility and stability, can obtain longer implanting cycle and is not liable to cause rejection and inflammatory response after long-term implantation; and the artificial nasolacrimal duct can be expanded by absorbing water and can achieve the self-fixing effect; and the implanting mode is simple and easy to operate.

Description

technical field [0001] The invention relates to a polymer material, in particular to a hydrogel and its application. Background technique [0002] The nasolacrimal ducts are two ducts that discharge tears from the eyes into the nasal cavity. The one located in the bony official cavity is called the inner bone, which is about 12.4mm, and the one located in the mucosa of the outer wall of the nasal cavity is called the inner nasal cavity, which is about 5.32mm long. Epiphora is a common and relatively common eye disease. It is a frequently-occurring disease caused by tear fluid stagnation in the lacrimal sac due to stenosis or blockage of the nasolacrimal duct. Patients with this disease will cry for a long time, which seriously affects the quality of life of the patient. At present, the traditional treatment methods for such diseases are mainly lacrimal duct probing and dacryocystorhinostomy, but this type of operation is not only complicated to operate, seriously damaged, bu...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F220/20C08F220/28A61L27/52A61L27/50A61L27/16A61L27/18
CPCA61L27/16A61L27/18A61L27/50A61L27/52C08F220/20C08J3/075C08J2333/14C08L33/066C08L71/02C08F220/286
Inventor 李锐聪杨习锋曾晨光
Owner 广州锐澄医疗技术有限公司
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