A kind of preparation method of the single medicine pellet containing volatile oil

A technology for volatile oil and single-drug, applied in the field of preparation of single-drug pellets, can solve the problems of large differences in the content of traditional Chinese medicine ingredients, low utilization rate of medicinal materials, unstable drug release, etc. Compliance, the effect of reducing the amount of water

Active Publication Date: 2021-06-11
河南泓医药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high viscosity of traditional Chinese medicine or herbal medicine extracts, most traditional granule preparation methods have problems such as low drug loading, unsightly appearance, bitter taste, easy moisture absorption, unstable drug release, and low utilization of medicinal materials.
The invention patent with the application publication number of CN1386495A on the processing method and technology of Chinese medicine ultrafine particles discloses a processing method of traditional Chinese medicine ultrafine particles. To meet the needs of dialectical treatment of traditional Chinese medicine, it can be modified and tailored according to the symptoms, and the formula is flexible. It does not need to be boiled when used. It can be taken directly by soaking in boiling water for about 3 to 20 minutes. It not only maintains the nature, taste and function of traditional Chinese medicine, but also avoids It saves the trouble of decocting, is convenient for patients to take, and is economical, hygienic, fast and convenient, but the content of Chinese medicine ingredients in the ultrafine particles prepared from the same Chinese medicine in different regions or different batches is quite different.
[0004] When the active ingredients of traditional Chinese medicine containing volatile oil are extracted, if the volatile oil is not collected, the yield of the active ingredients is low

Method used

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  • A kind of preparation method of the single medicine pellet containing volatile oil
  • A kind of preparation method of the single medicine pellet containing volatile oil
  • A kind of preparation method of the single medicine pellet containing volatile oil

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Embodiment 1

[0031] The preparation method of the peppermint pellet of the present embodiment may further comprise the steps:

[0032] 1) Preparation of dry cream powder: take fresh mint, wash it, crush it as appropriate, add water twice the mass of fresh mint, place it in an ultrasonic-assisted extraction and concentration unit, and perform a reflux extraction for 2 hours. Ultrasonic treatment for 40 minutes under the conditions, and filtration after the completion of the primary reflux extraction to obtain a primary decoction, and collect the primary volatile oil during the primary reflux extraction. Add water of 1 times the quality of the filter residue to the filter residue, perform secondary reflux extraction for 1 hour, ultrasonically treat for 30 minutes under the condition of 26 kHz during the secondary reflux extraction, and filter after the secondary reflux extraction to obtain a secondary decoction, and collect the secondary reflux Secondary volatile oils during stream extractio...

Embodiment 2

[0047] The preparation method of the peppermint pellet of the present embodiment may further comprise the steps:

[0048] 1) Preparation of dry paste powder: take fresh mint, wash it, crush it as appropriate, then add water with 1 times the mass of fresh mint, place it in an ultrasonic-assisted extraction and concentration unit, and perform a reflux extraction for 1 hour. Ultrasonic treatment for 90min under the conditions, and filtration after the completion of the primary reflux extraction to obtain a primary decoction, and collect the primary volatile oil during the primary reflux extraction. Add water with 3 times the quality of the filter residue to the filter residue, carry out secondary reflux extraction for 2 hours, during the secondary reflux extraction, ultrasonic treatment under the condition of 20kHz for 60min, filter after the secondary reflux extraction, obtain the secondary decoction, and collect the secondary reflux Secondary volatile oils during stream extract...

Embodiment 3

[0058] The preparation method of the angelica micropill of the present embodiment, comprises the following steps:

[0059] 1) Preparation of dry cream powder: take Angelica sinensis, crush it and pass through a 10-mesh sieve, add water to moisten it thoroughly, add water 4 times the mass of Angelica sinensis after moistening, place it in an ultrasonic-assisted extraction and concentration unit, perform a reflux extraction for 2 hours, and a reflux Ultrasonic treatment was performed for 90 minutes under the condition of 50 kHz during the extraction period, and the primary decoction was obtained by filtering after the primary reflux extraction, and the primary volatile oil in the primary reflux extraction process was collected. Add water of 2 times the quality of the filter residue to the filter residue, perform secondary reflux extraction for 1 hour, ultrasonically treat for 30 minutes under the condition of 20 kHz during the secondary reflux extraction, and filter after the sec...

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Abstract

The present invention relates to a kind of volatile oil-containing single herb pellets and a preparation method thereof. The method comprises the following steps: take the medicinal material and add water, and then reflux extract it once, perform ultrasonic treatment, and filter to obtain a decoction, and collect the volatile oil once; Add water to the mixture, extract by reflux for the second time, and ultrasonically treat and filter to obtain the second decoction, and collect the second volatile oil; combine the decoction, concentrate, and dry to obtain dry cream powder; combine to obtain the total volatile oil; take several batches Prepare dry paste powder from medicinal materials, and mix the dry paste powder into dry paste raw material powder that meets the requirements; take auxiliary materials, spray into the total volatile oil, and then coat to obtain cured peppermint oil; mix the cured medicinal material oil into the required cured Medicinal material raw material oil: take dry paste raw material powder and cured medicinal material raw material oil respectively, mix according to the proportion, and make pellets. The method has a high yield of active ingredients, and the prepared micropills are decocting-free, easy to carry, have uniform ingredients, and have stable and reliable curative effects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of single medicine pellets containing volatile oil. Background technique [0002] Pellets, also known as small pills, refer to small spherical oral dosage forms with a diameter of about 1mm, generally no more than 2.5mm. With the development of modern pharmacy, it has been found that compared with other oral preparations, micropill preparations have many advantages. For example, a dose is composed of multiple dispersion units, which can be dispersed in a large area and evenly in the gastrointestinal tract after oral administration. Improve the bioavailability of the drug; the transport in the gastrointestinal tract is not affected by gastric emptying, and the absorption reproducibility is good; the combination of pellets with different drug release rates can easily achieve the expected drug release rate and achieve the ideal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/10A61K36/534A61K36/232
CPCA61K9/5031A61K36/232A61K36/534A61K2236/331A61K2236/39A61K2236/51
Inventor 王世峰荆晓玉
Owner 河南泓医药业有限公司
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