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Radix et rhizoma ginseng, radix panacis quinquefolii and radix notoginseng solid fermentation processing method

A technology of solid fermentation and processing method, which is applied in the fields of pharmaceutical formula, medical preparations containing active ingredients, food science, etc. It can solve the problems of low bioavailability, low content of rare ginseng saponins, etc., and achieve the effect of low cost

Active Publication Date: 2018-03-23
JILIN YATAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention discloses a processing method for solid fermentation of ginseng, American ginseng and notoginseng. The fermentation and biotransformation of ginseng, American ginseng and notoginseng by Schizophyllum not only converts ginsenosides in these three medicinal materials into rare ginsenosides, Moreover, its lignocellulose is also decomposed and utilized by Schizophyllum, producing a large amount of biologically active substances such as Schizophyllan, which significantly improves the efficacy of ginseng, American ginseng and Sanqi; solves the traditional processing of ginseng, American ginseng and Sanqi The shortcomings of ginseng rare saponins in the product are low content and low bioavailability

Method used

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  • Radix et rhizoma ginseng, radix panacis quinquefolii and radix notoginseng solid fermentation processing method
  • Radix et rhizoma ginseng, radix panacis quinquefolii and radix notoginseng solid fermentation processing method
  • Radix et rhizoma ginseng, radix panacis quinquefolii and radix notoginseng solid fermentation processing method

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Effect test

Embodiment 1

[0037] The whole root of fresh ginseng was used as the solid fermentation substrate, and the water content of fresh ginseng was 40%. After sterilizing at 121°C for 30 minutes, the cultivated Schizophyllum ferment strain was inoculated into the solid fermentation medium at an inoculation amount of 10%. Cultivate in the dark at 25°C for 20 days; the fermented product after fermentation is dried at 40°C. The original ginsenosides in the fermentation product were degraded, and a large amount of rare ginsenoside 20R-Rg was produced 3 、20S-Rg 3 , Rg 5 , Rk1, F 2 , compound K, compound O, compound Y, compound Mc1, compound Mc, C-Mx1 and C-Mx (see figure 1 with 2 ); at the same time, the contents of soluble total sugar, protein, fat-soluble components, total saponins and total extracts in the fermented product all increased significantly (see image 3 ).

Embodiment 2

[0039] Use undergrowth ginseng powder as the solid fermentation substrate, add an appropriate amount of water to make the water content 60%, and after sterilizing at 121°C for 30 minutes, inoculate the cultured Schizophyllum fermentation strains into the solid fermentation with an inoculum of 15%. In the culture medium, it is cultivated in the dark at 28°C for 10 days; the fermented product after fermentation is dried at 50°C.

Embodiment 3

[0041] The whole fresh American ginseng was used as the solid fermentation substrate, and the water content of American ginseng was 50%. After sterilizing at 121°C for 30 minutes, the cultured Schizophyllum ferment strain was inoculated into the solid fermentation medium at an inoculation amount of 20%. Cultivate in the dark for 25 days under the condition of ℃; the fermented product after fermentation is dried at 60 ℃. The original ginsenosides in the fermentation product were degraded, producing a large amount of rare ginsenoside F 2 and compound K (see Figure 4 with 5 ); at the same time, the contents of soluble total sugar, protein, fat-soluble components, total saponins and total extracts in the fermented product all increased significantly (see Image 6 ).

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Abstract

The invention discloses a radix et rhizoma ginseng, radix panacis quinquefolii and radix notoginseng solid fermentation processing method. After radix et rhizoma ginseng, radix panacis quinquefolii and radix notoginseng are fermented and biologically converted by schizophyllum commune, ginsenoside in the three medicinal materials can be converted into rare ginsenoside, lignocelllulose of the threemedicinal materials is also decomposed and utilized by the schizophyllum commune, a lot of biological active matter of schizophyllan and the like can be generated, and effects of the radix et rhizomaginseng, the radix panacis quinquefolii and the radix notoginseng are remarkably improved; thus, the shortcomings that traditional processed products of the radix et rhizoma ginseng, the radix panacis quinquefolii and the radix notoginseng have a low rare ginsenoside content, a low bioavailability and the like are overcome.

Description

technical field [0001] The invention relates to a processing method for solid fermentation of ginseng, American ginseng and notoginseng, relates to a processing method for solid fermentation of ginseng, American ginseng and notoginseng by using schizophyllum, and belongs to the technical field of solid fermentation of edible and medicinal fungi. Background technique [0002] Ginseng, American ginseng and Panax notoginseng are currently the most popular Chinese herbal medicines in the world. They have a long history of medicinal and nourishing health care in my country, and have extremely high medicinal and economic value. As representative nourishing medicines of traditional Chinese medicine, the demand for these three kinds of Chinese herbal medicines is increasing year by year in my country and economically developed countries and regions such as Southeast Asia, Europe and the United States. my country is a big producer and exporter of these three kinds of Chinese herbal m...

Claims

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Application Information

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IPC IPC(8): A61K36/258C12N1/14A23L33/00A61P39/00
CPCA61K36/258A61K2236/19A23L33/00C12N1/14A61K2300/00
Inventor 刘志李玉孙光芝阮长春王立娟
Owner JILIN YATAI PHARM CO LTD
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