Focusing controllable super-resolution microscopic device based on spherical micro nano liquid drop lens

A droplet lens and super-resolution technology, used in microscopes, measuring devices, analytical materials, etc., can solve problems such as uncontrollable focusing characteristics, and achieve the effects of convenient construction, high scanning accuracy, and simple optical path.

Pending Publication Date: 2018-03-23
CHINA JILIANG UNIV
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Problems solved by technology

[0004] The present invention aims at the disadvantages of uncontrollable focusing characteristics when the existing micro-nano structure realizes super-resolu

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  • Focusing controllable super-resolution microscopic device based on spherical micro nano liquid drop lens
  • Focusing controllable super-resolution microscopic device based on spherical micro nano liquid drop lens
  • Focusing controllable super-resolution microscopic device based on spherical micro nano liquid drop lens

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Embodiment Construction

[0026] The present invention will be described in detail below in conjunction with the accompanying drawings, but the present invention is not limited thereto.

[0027] Such as figure 1 Shown is a schematic diagram of a focus controllable super-resolution microscopic device based on a spherical micro-nano droplet lens of the present invention, including: a laser 1, a mirror 2, a first lens group 3, a dichromatic mirror 4, a linear polarizer 5, a microscopic Objective lens 6, packaging box 7, spherical micro-nano droplet lens 8, micro-flow tube 9, micro-displacement stage 10, sample stage 11, second lens group 12, imaging device 13, computer control system 14.

[0028] Among them, laser 1 is a LE-LS-589-XXT visible light semiconductor-pumped all-solid-state laser produced by Shenzhen Leo Optoelectronics Technology Co., Ltd., with a power of 1-4500 milliwatts and an operating wavelength of 589 nanometers.

[0029] The beam output by the laser 1 is incident on the mirror 2, and ...

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Abstract

The invention discloses a focus-controllable super-resolution microscopic device based on a spherical micro-nano droplet lens, comprising: a laser, a mirror, a first lens group, a dichromatic mirror, a linear polarizer, a microscopic objective lens, a packaging box, Spherical micro-nano droplet lens, micro-flow tube, micro-displacement stage, sample stage, second lens group, imaging device, computer control system. The computer control system controls the microfluidic tube to release or absorb a certain volume of liquid droplets in the packaging box, and then regulates the radius of the spherical micro-nano liquid droplet lens to realize zooming of the spherical micro-nano liquid droplet lens. Aiming at the disadvantages of the uncontrollable focusing characteristics of the existing micro-nano structure, the present invention proposes a focus-controllable super-resolution microscopic device based on a spherical micro-nano droplet lens, which uses the spherical micro-nano droplet lens to generate photon nanojet , by adjusting the focusing characteristics of the spherical micro-nano droplet lens, the scanning of the sample at different depths can be realized without mechanical structure vibration; and it can be combined with the micro-stage to control the sample stage to realize the horizontal scanning, and complete the three-dimensional ultra-scanning of the sample. Resolution microscopy imaging.

Description

technical field [0001] The invention relates to the field of optical microscopic imaging, in particular to a focus-controllable super-resolution microscopic device based on a spherical micro-nano droplet lens. Background technique [0002] Since Abbe proposed the concept of the optical diffraction limit in 1873, how to break through the optical diffraction limit and obtain higher-quality high-resolution images has been a hot topic in academic research. Until the emergence of super-resolution optical imaging technology, it broke through the resolution limit of conventional optical microscopes and provided unprecedented solutions for research in the fields of life sciences and biological cytology. At present, the mainstream super-resolution optical microscopy technology is mainly divided into: target switching and reading microscopy technology represented by fluorescence emission loss microscopy proposed by S.W.Hell et al. and photosensitive positioning microscopy technology p...

Claims

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Application Information

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IPC IPC(8): G02B21/00G02B21/33G01N21/64
CPCG02B21/0076G01N21/6458G01N2021/6478G02B21/002G02B21/0068G02B21/33
Inventor 李旸晖李雨雪周辉王乐
Owner CHINA JILIANG UNIV
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