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Orally disintegrating clozapine tablets prepared by 3D printing and preparation method thereof

An orally disintegrating tablet and 3D printing technology are applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. Convenience and quickness, the effect of improving the success rate and compliance

Active Publication Date: 2018-03-30
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For some patients who are ineffective or poorly cured by traditional antipsychotic drugs, it may be effective to switch to this product

Method used

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  • Orally disintegrating clozapine tablets prepared by 3D printing and preparation method thereof
  • Orally disintegrating clozapine tablets prepared by 3D printing and preparation method thereof
  • Orally disintegrating clozapine tablets prepared by 3D printing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The prescription of 3D printed clozapine orally disintegrating tablets is as follows:

[0030]

[0031] 3D printing parameters are as follows:

[0032]

[0033] The preparation method is as follows:

[0034] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into a st1 format file and import it into the LTY software control system of the 3D printer.

[0035] (2) Calculated by weight percentage, 20% clozapine, 65% mannitol, 10% sucrose, and 305% PVP K are mixed evenly in proportion, and packed into the powder and ink cartridge of the 3D printing rapid prototyping machine as medicinal powder.

[0036] (3) Put 25% ethanol into the cartridge.

[0037] (4) The control system outputs printing instructions, the powder spreading device spreads the powder on the 3D printing platform, the printing nozzle of the 3D printing system moves in the X-Y axis direction, and sprays the bonding liquid on the powder according to the set mode...

Embodiment 2

[0042] The prescription of 3D printed clozapine orally disintegrating tablets is as follows:

[0043]

[0044] 3D printing parameters are as follows:

[0045]

[0046]

[0047] The preparation method is as follows:

[0048] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into a st1 format file and import it into the LTY software control system of the 3D printer.

[0049] (2) Calculated by weight percentage, mix clozapine 30%, pregelatinized starch 50%, maltodextrin 10%, PVPK 308%, and sucralose 2% in proportion, and load it into a 3D printing rapid prototyping machine as a medicine powder in the toner cartridge.

[0050] (3) Put 2% PVP K30-25% ethanol into the cartridge.

[0051] (4) The control system outputs printing instructions, the powder spreading device spreads the powder on the 3D printing platform, the printing nozzle of the 3D printing system moves in the X-Y axis direction, and sprays the bonding liquid on the...

Embodiment 3

[0056] The prescription of 3D printed clozapine orally disintegrating tablets is as follows:

[0057]

[0058] The 3D printing parameters of this embodiment are as follows:

[0059]

[0060]

[0061] The preparation method is as follows:

[0062] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into a st1 format file and import it into the LTY software control system of the 3D printer.

[0063] (2) Calculated by weight percentage, mix 50% of clozapine, 38% of mannitol, 10% of PVP K30, and 2% of stevioside evenly in proportion, and put them into the powder and ink box of the 3D printing rapid prototyping machine as medicine powder.

[0064] (3) Fill the cartridge with 50% ethanol.

[0065] (4) The control system outputs printing instructions, the powder spreading device spreads the powder on the 3D printing platform, the printing nozzle of the 3D printing system moves in the X-Y axis direction, and sprays the bonding liquid...

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Abstract

The invention discloses orally disintegrating clozapine tablets prepared by 3D printing. The orally disintegrating clozapine tablets are prepared from the following components in percent by weight bya 3D printing technology: 10-60% of clozapine, 30-90% of a filling agent, 1-10% of a dry adhesive, 0-1.0% of silica gel micropowder and 0-2% of a corrigent. The invention further discloses a preparation method of the orally disintegrating clozapine tablets. The orally disintegrating clozapine tablets provide by the invention are high in disintegrating speed, do not need a large amount of water fordelivery, and can be quickly disintegrated in an oral cavity when saliva is encountered, which is of a great significance in improving the medicine-taking success rate and the compliance of a patientsuffering from psychosis.

Description

technical field [0001] The invention relates to a clozapine orally disintegrating tablet, in particular to a clozapine orally disintegrating tablet prepared by 3D printing. The invention also relates to a preparation method of the clozapine orally disintegrating tablet. Background technique [0002] Three-dimensional printing technology (three dimension printing, 3DP) is a rapid prototyping technology based on digital models. The core idea of ​​3D printing first originated in the United States at the end of the 19th century, and it was not until the late 1980s that it was developed by the Massachusetts Institute of Technology. 3D printing technology is to design and construct a three-dimensional model on computer software based on the CAD model or CT data of the object. It can quickly and accurately manufacture objects with special shapes or complex internal structures. [0003] 3D printing technology was initially used in the fields of manufacturing, aerospace and indust...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/551A61K47/04A61P25/18B33Y70/00
CPCA61K9/0056A61K9/2009A61K9/2095A61K31/551B33Y70/00
Inventor 黄思玉陈燕忠吕竹芬
Owner GUANGDONG PHARMA UNIV
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