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Ephedrine extraction method

An extraction method, ephedrine technology, applied in the field of natural medicine extraction, can solve problems such as increased capillary pressure, excessive contraction of mucosal blood vessels, aggravated bronchial smooth muscle spasm, etc., and achieves the effect of stable extraction and high extraction rate

Inactive Publication Date: 2018-04-10
何本科
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term application can cause excessive contraction of mucosal blood vessels, increase capillary pressure, and aggravate congestion and edema.
In addition, the α effect can still aggravate bronchial smooth muscle spasm

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1) Cut the stems and branches of Ephedra herba into 5cm lengths, add 8 times the amount of water, and soak for 5 times, each time for 3 hours, to obtain an aqueous solution containing total alkaloids of ephedra;

[0020] 2) Alkalinize the aqueous solution obtained in step 1) with sodium hydroxide to a pH of 12, extract with 2 times the amount of acetone solution at 40°C, add 2 times the amount of oxalic acid solution to the extract, and adjust the pH of the solution to 8 , separate the oil layer to obtain the oxalate dilute solution of ephedra total alkaloids;

[0021] 3) concentrating the dilute oxalate solution of ephedra total alkaloids obtained in step 2) at 75°C under reduced pressure, cooling to 30°C, separating out crystals, and centrifuging to obtain crude ephedrine oxalate;

[0022] 4) Add 10 times of water and filter to the ephedrine oxalate crude product obtained in step 3), add calcium chloride solution to the filtrate under stirring until no precipitation o...

Embodiment 2

[0026] 1) Cut the stems and branches of Ephedra chinensis into 3 cm long, add 10 times the amount of water, and soak for 3 times, each time for 5 hours, to obtain an aqueous solution containing total alkaloids of ephedra;

[0027] 2) Alkalinize the aqueous solution obtained in step 1) with sodium hydroxide to a pH of 12, extract with 2 times the amount of acetone solution at 40°C, add 2 times the amount of oxalic acid solution to the extract, and adjust the pH of the solution to 8 , separate the oil layer to obtain the oxalate dilute solution of ephedra total alkaloids;

[0028] 3) concentrating the dilute oxalate solution of ephedra total alkaloids obtained in step 2) at 75°C under reduced pressure, cooling to 30°C, separating out crystals, and centrifuging to obtain crude ephedrine oxalate;

[0029] 4) Add 10 times of water and filter to the ephedrine oxalate crude product obtained in step 3), add calcium chloride solution to the filtrate under stirring until no precipitatio...

Embodiment 3

[0033] 1) Cut the stems and branches of Ephedra herba into 4 cm long, add 89 times the amount of water, soak for 4 times, each time for 4 hours, to obtain an aqueous solution containing total alkaloids of ephedra;

[0034] 2) Alkalinize the aqueous solution obtained in step 1) with sodium hydroxide to a pH of 12, extract with 3 times the amount of acetone solution at 35°C, add 3 times the amount of oxalic acid solution to the extract, and adjust the pH of the solution to 8 , separate the oil layer to obtain the oxalate dilute solution of ephedra total alkaloids;

[0035] 3) concentrating the dilute oxalate solution of ephedra total alkaloids obtained in step 2) at 72°C under reduced pressure, cooling to 32°C, separating out crystals, and centrifuging to obtain crude ephedrine oxalate;

[0036] 4) Add 9 times of water and filter to the ephedrine oxalate crude product obtained in step 3), and add calcium chloride solution to the filtrate under stirring to no longer produce preci...

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PUM

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Abstract

The invention belongs to the technical field of natural medicine extraction, and particularly relates to an ephedrine extraction method. The method comprises the following steps that 1, ephedrae herbais prepared into an aqueous solution containing ephedra total alkali; 2, alkalization is conducted, extraction is conducted with an acetone solution at 30-40 DEG C, an oxalic acid solution is added into extraction liquid, the pH of the solution is adjusted to 8, and an oil layer is removed; 3, an oxalate dilute solution with the ephedra total alkali is subjected to decompressed concentration at 70-75 DEG C and cooled to 30-35 DEG C, crystals are separated out, and a crude oxalic acid ephedrine product is obtained; 4, 8-10 times amount of water is added into the crude oxalic acid ephedrine product, filtration is conducted, when filtrate is stirred, a calcium chloride solution is added to the filtrate till precipitate is not generated any longer, and an ephedrine salt solution is obtained;5, a sodium sulfide solution is added into the ephedrine salt solution to adjust the pH to 7.5-8, standing is conducted to precipitate calcium oxalate, supernatant is taken after filtration, hydrochloric acid is added to adjust the pH to 6-6.5, and extraction filtration and crystallization are conducted to obtain the finished product. By means of the ephedrine extraction method, ephedrine can be stably extracted from ephedrae herba, and the extraction rate is up to 1.70%.

Description

technical field [0001] The invention belongs to the technical field of natural medicine extraction, and in particular relates to an extraction method of ephedrine. Background technique [0002] Ephedrine has good medicinal value, such as preventing bronchial asthma attacks and relieving mild asthma attacks, but it is not effective for acute severe asthma attacks; it is used for hypotension and chronic hypotension caused by subarachnoid anesthesia or epidural anesthesia. Hypertension; treatment of nasal congestion caused by various reasons, nasal congestion caused by swelling. It can directly stimulate adrenergic receptors, and can also indirectly stimulate adrenergic receptors by promoting the release of norepinephrine from adrenergic nerve endings. It has stimulating effects on both α and β receptors: 1. Cardiovascular system: make the skin , Mucous membrane and visceral blood vessels constrict, blood flow decreases; coronary and cerebral blood vessels dilate, blood flow i...

Claims

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Application Information

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IPC IPC(8): C07C213/10C07C215/30
CPCC07C213/10C07C215/30
Inventor 何本科
Owner 何本科
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