Anaplastic lymphoma kinase inhibitor, preparation method and uses thereof

A compound and the selected technology are applied in the direction of antineoplastic drugs, pharmaceutical formulations, organic active ingredients, etc., and can solve problems such as drug resistance
CN107936024AActive Publication Date: 2018-04-20CENTAURUS BIOPHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CENTAURUS BIOPHARMA
Publication Date
2018-04-20

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Abstract

The present invention relates to a compound represented by a formula (I), a pharmaceutical composition and a preparation method thereof, wherein the compound can be used as an ALK inhibitor to treat ALK-mediated diseases. The invention further relates to the preparation method of the compound represented by the formula (I), and applications of the compound represented by the formula (I) and the pharmaceutical composition thereof in preparation f drugs for treatment of ALK-mediated diseases. The formula (I) is defined in the specification.
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Description

technical field

[0001] The present invention relates to novel pyrrolopyrimidine derivatives with protein kinase inhibitory activity, their preparation method, pharmaceutical composition, and the use of such compounds and their pharmaceutical compositions in treating diseases related to protein kinases. Background technique

[0002] ALK (alternative lymphokinase) is a receptor-type protein tyrosine phosphokinase that belongs to the insulin receptor superfamily. It has been reported that as a result of gene abnormality (translocation, point gene mutation or gene amplification) of ALK, abnormal kinases fused with other genes are produced and involved in carcinogenesis.

[0003] For example, in lung cancer, ALK combines with the intracellular skeleton protein EML4 through chromosomal translocation to produce EML4-ALK with activated tyrosine kinase activity, and acquires the ability to become cancerous (Proc.Natl.Acad.Sci.USA, 2004 , 101, 13306-13311).

[0004] In addition, abn...

Claims

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