Error extraction method of magnetic particle detection system and apparatus thereof

Abstract

The invention relates to an error extraction method of a magnetic particle detection system and an apparatus thereof. Two relatively independent magnetic particle detection methods are used, a relation between voltage of an induction coil and inductance of the induction coil is established by taking magnetic conductivity as hidden variable, error extraction between a theoretical value of the inductance of the induction coil and a measured value is realized, and the induction voltage error and resonance frequency error are obtained. In the error extraction apparatus, an input terminal of a signal operation module (8) is connected with an induction coil of the magnetic particle detection system, the voltage of the induction coil is calculated, and the theoretical value of the inductance of the induction coil is calculated. The output terminal of the signal operation module (8) is connected with the input terminal of an error extraction module (10). The input terminal of a sweep-frequencymeasuring module (9) is connected with the induction coil of the magnetic particle detection system, the inductance value of the induction coil is measured, and the output terminal of the sweep-frequency measuring module (9) is connected with the input terminal of the error extraction module (10). The error extraction module (10) is capable of calculating the inductance error of the induction coil, the voltage error, and the resonance frequency error.

Description

Technical field [0001] The invention relates to an error extraction method and device of a magnetic particle detection system. Background technique [0002] Magnetic particle (MP) is a chemically synthesized material that uses ferromagnetic material as the core. Its particle size is small (micron or even nanometer), large specific surface, high coupling capacity, magnetic responsiveness, and biological Compatibility and very high adsorption capacity. Based on these characteristics, magnetic particles have been widely used in biomedicine fields such as magnetic separation, biological sample processing, biomolecular detection and identification, drug targeted therapy, hyperthermia, and tissue engineering. [0003] Magnetic particles have high adsorption capacity and can be used as carriers of biological macromolecules to complete the task of targeted therapy. In addition, the magnetic particles can be manipulated by an external magnetic field, such as aggregation, movement, elution...

AI Technical Summary

Problems solved by technology

For environmental factors, such as the influence of geomagnetism, the inductance method does not take into account, and the voltage method involves differential coil design, which achieves partial compensation to reduce the impact, but neither makes a quantitative analysis of the impact effect

[0018] The two MPD detection methods mentioned above are relatively independent. In the past, in the field of magnetic particle detection, there were only means to reduce the error as much as possible, such as differential coil design, Chinese patent 201410018349.8, but it can only partially remove the influence of the environmental magnetic field, and there is no Effect analysis, there is also the problem that the influence of the change of magnetic permeability has not been considered

[0019] Chinese patent 201410337351.1, a biological sample detector based on the nonlinear magnetization characteristics of magnetic beads, has not considered the influence of magnetic permeability changes and environmental impact

Images