Contact lenses for drug administration treatment of fungal keratitis

A fungal keratitis and contact lens technology, applied in the field of medical devices, can solve the problems of prolonged residence time, low treatment risk, inability to guarantee continuous treatment effect, etc., to achieve high bioavailability and ensure continuous supply.

Inactive Publication Date: 2018-04-24
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] For the above deficiencies or improvement needs of the prior art, the object of the present invention is to provide a contact lens for the treatment of fungal keratitis, wherein through the material of the contact lens and the internal structure of the lens (especially microfluidic channels, The overall structure of the hollow cavity and the liquid outlet, and the specific shape and size parameters of each microfluidic channel, the hollow cavity and the liquid outlet, etc.) design and corresponding process are improved to ensure that the contact lens does not affect vision. In this context, using contact lenses as a drug delivery system can effectively overcome the shortcomings of tradi

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  • Contact lenses for drug administration treatment of fungal keratitis
  • Contact lenses for drug administration treatment of fungal keratitis
  • Contact lenses for drug administration treatment of fungal keratitis

Examples

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[0025] Example 1

[0026] like Figure 1A , Figure 1B and figure 2 As shown, the present invention is a contact lens for treating fungal keratitis, which is a curved contact lens as a whole, and the contact lens includes a soft layer, a hard layer, a hollow microcavity, and a micro fluid channel , liquid outlet and other structures (hollow micro-cavities and micro-fluid channels can be set in the soft layer; the hard layer has a certain strength, such as the Young's modulus of 0.1-10GPa level, the soft layer and the hard layer The difference lies in the softness and hardness of the materials used. The hard layer is harder than the soft layer. Correspondingly, the soft layer is also softer than the hard layer. The softness and hardness of the material can be compared according to the degree of local plastic deformation on the surface of the material. , the soft layer can be, for example, a material with a Young's modulus of 0.1-10 MPa).

[0027] The contact lens has a spheri...

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Abstract

The invention discloses contact lenses for drug administration treatment of fungal keratitis. Each contact lens is integrally presented as a spherical corneal contact lens (1), each spherical cornealcontact lens (1) is mainly composed of two parts of a soft layer (7) and a hard layer (8) through bonding superposition and thermoforming process, and a microfluidic channel (3) and a hollow cavity (4) are formed inside each contact lens (1); each hollow cavity (4) is used for storing a liquid drug ( 5); each microfluidic channel (3) is used for delivering the liquid drug (5), one end of each microfluidic channel (3) is communicated with the corresponding hollow cavity (4) and the other end of each microfluidic channel (3) is communicated with a corresponding liquid outlet (2) for making eachcontact lens (1) ) communicated with the outside world. According to the contact lenses, through the improvement of the materials of the contact lenses and the internal structures of the lenses and the corresponding process, the contact lenses are used as a drug delivery system under the premise of ensuring that the contact lenses do not affect the vision, and the defects that it cannot guaranteethe continuous treatment effect and the bioavailability is poor in the traditional drug administration method can be effectively overcome.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and more specifically relates to a contact lens for drug treatment of fungal keratitis, which is designed for fungal keratitis and can be administered according to eye activity Treat fungal keratitis, and ensure that the contact lens can continuously deliver medicine to the eyes to ensure the therapeutic effect. Background technique [0002] Fungal keratitis is an infectious corneal disease with a high rate of blindness caused by pathogenic fungi. The common pathogens are Fusarium and Aspergillus. It may cause fungal keratitis, which has the characteristics of slow onset and long course, and the course of disease can often reach 2-3 months. Many farmers in my country have suffered from fungal keratitis. [0003] For fungal keratitis, traditional treatment methods such as instillation, due to the dilution of tears, the residence time of the drug in the eye is relatively short, resulting in...

Claims

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Application Information

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IPC IPC(8): A61F9/00G02C7/04G02C7/02
Inventor 陈良洲金磊陈有林安宏彬宋永峰
Owner HUAZHONG UNIV OF SCI & TECH
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