Contact lenses for drug administration treatment of fungal keratitis

Abstract

The invention discloses contact lenses for drug administration treatment of fungal keratitis. Each contact lens is integrally presented as a spherical corneal contact lens (1), each spherical cornealcontact lens (1) is mainly composed of two parts of a soft layer (7) and a hard layer (8) through bonding superposition and thermoforming process, and a microfluidic channel (3) and a hollow cavity (4) are formed inside each contact lens (1); each hollow cavity (4) is used for storing a liquid drug ( 5); each microfluidic channel (3) is used for delivering the liquid drug (5), one end of each microfluidic channel (3) is communicated with the corresponding hollow cavity (4) and the other end of each microfluidic channel (3) is communicated with a corresponding liquid outlet (2) for making eachcontact lens (1) ) communicated with the outside world. According to the contact lenses, through the improvement of the materials of the contact lenses and the internal structures of the lenses and the corresponding process, the contact lenses are used as a drug delivery system under the premise of ensuring that the contact lenses do not affect the vision, and the defects that it cannot guaranteethe continuous treatment effect and the bioavailability is poor in the traditional drug administration method can be effectively overcome.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and more specifically relates to a contact lens for drug treatment of fungal keratitis, which is designed for fungal keratitis and can be administered according to eye activity Treat fungal keratitis, and ensure that the contact lens can continuously deliver medicine to the eyes to ensure the therapeutic effect. Background technique [0002] Fungal keratitis is an infectious corneal disease with a high rate of blindness caused by pathogenic fungi. The common pathogens are Fusarium and Aspergillus. It may cause fungal keratitis, which has the characteristics of slow onset and long course, and the course of disease can often reach 2-3 months. Many farmers in my country have suffered from fungal keratitis. [0003] For fungal keratitis, traditional treatment methods such as instillation, due to the dilution of tears, the residence time of the drug in the eye is relatively short, resulting in...

AI Technical Summary

Problems solved by technology

[0004] For the above deficiencies or improvement needs of the prior art, the object of the present invention is to provide a contact lens for the treatment of fungal keratitis, wherein through the material of the contact lens and the internal structure of the lens (especially microfluidic channels, The overall structure of the hollow cavity and the liquid outlet, and the specific shape and size parameters of each microfluidic channel, the hollow cavity and the liquid outlet, etc.) design and corresponding process are improved to ensure that the contact lens does not affect vision. In this context, using contact lenses as a drug delivery system can effectively overcome the shortcomings of traditional drug delivery methods such as inability to guarantee sustained therapeutic effects and poor bioavailability compared with existing technologies. Compared with the existing traditional drug delivery technology, it has higher bioavailability and lower treatment risk. The invention can effectively improve the bioavailability of the drug, prolong the residence time of the drug on the cornea, and realize automatic , continuous drug treatment; and the present invention can effectively control a single liquid output (i.e. the liquid output of the drug liquid), especially in combination with the general blinking frequency of people, to continuously and stably deliver the drug liquid to the eyes

Images