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Muscone patch and preparation method and application thereof

A musk ketone patch and musk ketone technology are applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, sheet delivery, etc., which can solve the problems of lack of ischemic stroke, reduce MDA content, improve nerve function, The effect of improving SOD vitality

Active Publication Date: 2018-04-24
山东宏济堂制药集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the lack of suitable preparations for the treatment of ischemic stroke at present, the present invention needs to develop a new dosage form to overcome the defects of oral administration and injection preparations, avoid liver first-pass effect and gastrointestinal inactivation, and maintain a constant blood concentration to enhance the therapeutic effect , reduce toxic side effects

Method used

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  • Muscone patch and preparation method and application thereof
  • Muscone patch and preparation method and application thereof
  • Muscone patch and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 52.5mg of muscone and 25.0g of silicone pressure-sensitive adhesive to 3mL of ethyl acetate to dissolve, mix evenly, and stir for 0.5h in an airtight manner. 2 On the backing layer of polyethylene terephthalate, form the adhesive layer containing medicine, after drying, press and cover the anti-adhesive layer (200cm 2 ), punching and cutting to obtain 200 drug-loaded patches.

Embodiment 2

[0023] Add 105.0mg of muscone and 25.0g of silicone pressure-sensitive adhesive to 3mL of ethyl acetate to dissolve and mix evenly. Stir in an airtight chamber for 1 hour, degas under reduced pressure, and spread on 200cm 2 On the backing layer of polyethylene terephthalate, form the adhesive layer containing medicine, after drying, press and cover the anti-adhesive layer (200cm 2 ), punching and cutting to obtain 200 drug-loaded patches.

Embodiment 3

[0025] The drug effect animal experiment result of the prepared muscone patch of the present invention is as follows:

[0026] Dosing regimen:

[0027] Get 70 Wistar rats, randomly divide into sham operation group, model group, muscone patch high dose group (MHD) (4.20mg / kg), muscone patch medium dose group (MMD) (2.10mg / kg) , muscone patch low dose group (MLD) (1.05mg / kg), nimodipine group (ND) (4mg / kg) and Yinkeluo group (YKL) (40mg / kg), 10 animals in each group. The sham operation group and the model group were intragastrically administered with normal saline and pasted with a blank patch on the front side of the neck (common carotid artery) of the rats after hair removal; Paste on the neck of rats after hair removal; Nimodipine group and Yinkeluo group were given corresponding doses of nimodipine and Yinkeluo respectively, and a blank patch was pasted on the neck of rats after hair removal, every day 1 time, 7 days in a row.

[0028] Experiment 1: Protective effect of m...

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Abstract

The invention discloses a muscone patch and a preparation method and application thereof. The muscone patch comprises a backing layer and an anti-adhesive layer, a drug-containing adhesive layer is arranged between the backing layer and the anti-adhesive layer and comprises muscone and framework materials. The framework materials are silicone pressure-sensitive adhesive, the backing layer is polyethylene terephathalate, and the anti-adhesive layer is smooth thick paper treated with paraffin. According to the muscone patch and the preparation method and application thereof, muscone is preparedinto the patch, the defects of oral preparations and injection preparations are overcome, the first-pass effect of the liver and the gastro-intestinal inactivation can be avoided, the constant blood drug concentration is kept, the treatment effect is improved, and the toxic and side effects are reduced. By means of the patch, the use frequency of drugs can be reduced, and the patch is suitable forthe treatment of ischemic stroke in particular to the treatment in the recovery period of stroke.

Description

technical field [0001] The invention relates to the technical field of muskone medicine and its application, in particular to a muskone patch and its preparation method and application. Background technique [0002] Stroke has always been a serious disease that threatens human health, and ischemic stroke is the main type of stroke. Ischemic stroke is also called ischemic cerebrovascular disease. The key to its treatment is anti-cerebral edema, improvement of cerebral blood circulation and brain protection, so as to restore the blood supply of the ischemic area and save dying neurons. The treatment methods mainly include reducing intracranial pressure, regulating blood pressure, anticoagulation, thrombolysis, protecting microcirculation and brain protection. [0003] The traditional dosage forms for the treatment of ischemic stroke are mainly decoctions, capsules, oral liquids, tablets, and injections. However, these dosage forms have the disadvantages of large amount of us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/122A61P9/10
CPCA61K9/703A61K31/122
Inventor 魏永恒谭乐俊李利芬崔曰新战旗李樱孟兆青
Owner 山东宏济堂制药集团股份有限公司
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