Soluble PD-1 (programmed death-1) molecule with high affinity

A PD-1, PDL-1 technology, applied in the biological field, can solve the problems of tumor immune escape and weaken anti-tumor immune response
CN107987153AInactive Publication Date: 2018-05-04GUANGDONG XIANGXUE LIFE SCI LTD
1 Cites 7 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG XIANGXUE LIFE SCI LTD
Publication Date
2018-05-04
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a soluble PD-1 (programmed death-1) molecule with high affinity, and particularly provides a PD-1 molecule. The PD-1 molecule is mutated on the basis of a wild PD-1 molecule, and affinity of the PD-1 molecule and a PDL-1 (Programmed Death Ligand-1) molecule is at least twice that of the wild PD-1 molecule and a wild PDL-1 molecule. Meanwhile, the PD-1 molecule can effectively improve the killing capacity of lymphocytes. Besides, the invention provides nucleic acid encoding the PD-1 molecule and a PD-1 molecule complex. The PD-1 molecule can be used alone or in combination with other molecules.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to the field of biotechnology, more specifically to high-affinity soluble programmed death receptor (Programmed Death-1, PD-1) molecules that can recognize programmed death receptor ligand PDL-1 (Programmed Death-1) with high affinity Ligand-1, PDL-1) molecules. The present invention relates to the preparation method and use of this molecule. Background technique

[0002] PD-1 is an immunosuppressive receptor expressed on activated T cells and B cells, and its ligand is PDL-1 or PDL-2. PD-1 belongs to the B7 family and is an Ig superfamily type I transmembrane glycoprotein with a size of 50-55kD; it consists of three parts: the extracellular IgV region, the transmembrane region and the intracellular region. Membrane-proximal cysteine ​​residues, PD-1 exist as monomers (Xuewu Zhang and Almo, Immunity, 2004, 20, 337–347). PD-1 interacts with the ligand PDL-1 and plays an important role in the negative regulation of the im...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More