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Aerosol inhalation preparation capable of inhibiting or treating COPD and application thereof

An atomized inhalation agent and atomized inhalation technology, which is applied in respiratory diseases, sulfur/selenium/tellurium active ingredients, drug delivery, etc., to achieve the effects of increasing liver index and spleen index, improving weight loss, and broad clinical application prospects

Inactive Publication Date: 2018-05-08
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, no studies have reported that sodium hydrosulfide, especially in the form of aerosol inhalation, has the effect of inhibiting or treating COPD

Method used

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  • Aerosol inhalation preparation capable of inhibiting or treating COPD and application thereof
  • Aerosol inhalation preparation capable of inhibiting or treating COPD and application thereof
  • Aerosol inhalation preparation capable of inhibiting or treating COPD and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] In the following, the present invention will be further described in detail in combination with examples and accompanying drawings, inhalation of NaHS inhibits the occurrence and development of CS-induced COPD in mice, and this inhibitory effect is related to the regulation of CFTR expression and function. However, the following embodiments are only used to illustrate the purpose of the present invention, and do not limit the protection scope of the present invention.

[0029] 1. Main materials

[0030] 1. Main reagents and consumables for the experiment

[0031] Human airway epithelial cells 16HBE, Shanghai Cell Bank, Chinese Academy of Sciences;

[0032] Sodium hydrosulfide (NaHS), American Sigma company;

[0033] Red Rose brand cigarettes, Guangdong China Tobacco Industry Co., Ltd.;

[0034] Sodium pentobarbital, Guangzhou Chemical Plant No. 2;

[0035] Normal saline, Dongguan Puji Pharmaceutical Co., Ltd.;

[0036] PBS (Phosphate), Geno Biopharmaceutical Co., L...

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PUM

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Abstract

The invention discloses an aerosol inhalation preparation capable of inhibiting or treating a COPD. The aerosol inhalation preparation is a NaHS aerosol inhalation preparation. The aerosol inhalationpreparation has the efficacy of inhibiting or treating the COPD. The invention further discloses application of the aerosol inhalation preparation to preparation of medicines with the efficacy of inhibiting or treating the COPD.

Description

technical field [0001] The invention belongs to the technical field of chronic obstructive pulmonary disease, and in particular relates to an atomized inhalation preparation for inhibiting or treating COPD and its application in the preparation of medicaments capable of inhibiting or treating COPD. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by irreversible airflow limitation. The incidence rate in my country is as high as 8.2% (male 12.4%, female 5.1%). Mortality from COPD is rising, killing more than 3 million people worldwide each year. Excessive mucus secretion and inflammatory responses in the lungs induced by long-term cigarette smoke (cigarette smoke, CS) exposure are one of the main causes of the development of COPD. Cigarette smoke exposure leads to alveolar destruction by inducing the occurrence of acute and chronic inflammatory responses in the lungs, resulting in decreased lung functi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61K9/72A61P11/00
CPCA61K9/0078A61K33/04
Inventor 卢文菊王健李德富
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)