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Three-dimensional hotspot Raman detection chip based on shell-layer insulating nanoparticles

A nanoparticle, silver nanoparticle technology, applied in Raman scattering, measurement devices, instruments, etc., can solve the problems of long chip cycle, expensive sputtering gold plating technology, and difficulty in widespread promotion of portable surface-enhanced Raman detection technology.

Inactive Publication Date: 2018-05-08
XIAMEN SPEC TECH CO LTD
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  • Description
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Problems solved by technology

However, the preparation process of this kind of chip has a long cycle, and the ion beam etching and sputtering gold plating technologies are very expensive and complicated, so the preparation cost of the chip is very high, which brings great challenges to the widespread promotion of portable surface-enhanced Raman detection technology. difficulty

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  • Three-dimensional hotspot Raman detection chip based on shell-layer insulating nanoparticles
  • Three-dimensional hotspot Raman detection chip based on shell-layer insulating nanoparticles
  • Three-dimensional hotspot Raman detection chip based on shell-layer insulating nanoparticles

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Embodiment Construction

[0023] The schematic diagram of the low-light structure of the Raman spectrum detection chip based on the shell-isolated nanoparticles of the present invention is as follows figure 1 As shown, on a hydrophobic substrate 1, the shell-isolated nanoparticles 2 are tightly packed to form a three-dimensional structure, and a dense hot spot structure is formed between the particles. After the molecules of the analyte enter the hot spot, their The Raman spectrum signal will be greatly enhanced, increasing the detection sensitivity.

[0024] in:

[0025] (1) Synthesis of shell-isolated gold or silver nanoparticles. The nanoparticles used to enhance the Raman spectrum signal are shell-isolated gold or silver nanoparticles, that is, a layer of dense silica shell is coated on the surface of 150nm gold or silver nanoparticles. For the synthesis method, please refer to the patent number CN201010579701. 7 and CN201510287999.7. Synthetic particles such as figure 2 shown.

[0026] (2) H...

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Abstract

The invention discloses a three-dimensional hotspot Raman detection chip based on shell-layer insulating nanoparticles. The three-dimensional hotspot Raman detection chip comprises two parts, one partis a hydrophobic substrate, the other part is shell-layer insulating nanoparticles, and the shell-layer insulating nanoparticles are piled together to form a three-dimensional hotpot structure. The chip is applied to Raman spectrum detection, and has a relatively good enhancement effect for substances entering hotpots and is capable of greatly increasing Raman detection limits when being comparedwith a conventional two-dimensional SERS substrate or a pure metal substrate; in addition, due to an inert shell layer, nanoparticles are relatively stable, cannot be damaged by external environments, and cannot react with a substance to be detected to influence detection results, so that detection accuracy and stability are ensured; in addition, the preservation time of the substrate is prolonged, harsh preservation conditions are avoided, and the chip has characteristics of common products, so that use, preservation and circulation of the chip are facilitated.

Description

technical field [0001] The invention relates to a high-sensitivity and high-stability three-dimensional hotspot Raman spectrum detection chip based on shell-isolated nanoparticles. Background technique [0002] The rapid development of social economy has also brought about various environmental problems. Various pollutants (cyanides, polycyclic aromatic diameters and heavy metal ions, etc.) are constantly produced, which seriously endanger people's health and daily life. With the improvement of people's living standards, health and environmental protection are getting more and more attention. Therefore, the state, enterprises, and research institutions have introduced testing standards for various industries, fields, and substances, as well as market access mechanisms. Conventional detection methods for various hazardous substances (such as chromatography, mass spectrometry, etc.) require complex sample pretreatment processes, cumbersome operations, expensive equipment, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 李剑锋杨振威金志平
Owner XIAMEN SPEC TECH CO LTD
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