Honeysuckle extraction method, honeysuckle dry extract powder, honeysuckle detoxification capsules and preparation method thereof

An extraction method and detoxification capsule technology, which are applied in the directions of capsule delivery, antidote, powder delivery, etc., can solve the problems of insufficient utilization of honeysuckle, low chlorogenic acid extraction rate, low chlorogenic acid content, etc. Efficacy and utilization rate of medicinal materials, simple and effective extraction method, and the effect of improving the utilization rate of medicinal materials

Inactive Publication Date: 2018-05-15
广东广发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Honeysuckle is also known as double flower and silver flower. It is the dried flower bud of Lonicerae. It is a commonly used traditional Chinese medicine for clearing away heat and detoxifying, cooling wind and heat. Its main active ingredient is chlorogenic acid. Chlorogenic acid has a long history of medicinal use and has antibacterial and antiviral properties. , the effect of protecting the liver and gallbladder, etc., the active ingredients of honeysuckle have been extracted all the time. In the past, the extraction methods of chlorogenic acid include water extraction of lime milk, water extraction, water extraction and alcohol precipitation, dilute alcohol extraction and other common methods. The content of chlorogenic acid obtained by these methods is low, the extraction rate of chlorogenic acid is low, and the honeysuckle is not fully utilized, resulting in waste of resources. The dilute alcohol extraction method is a better extraction process at present, but the content of chlorogenic acid is obtained. not high
[0003] And because the chlorogenic acid content of the existing honeysuckle extract is not high, the honeysuckle extract is generally used as an adjuvant, but honeysuckle is good at clearing away heat and detoxifying, and the capsule with honeysuckle as the king medicine is also extremely effective in clearing away heat and detoxifying Yes, but there are relatively few compositions using honeysuckle as the monarch drug in the prior art

Method used

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  • Honeysuckle extraction method, honeysuckle dry extract powder, honeysuckle detoxification capsules and preparation method thereof
  • Honeysuckle extraction method, honeysuckle dry extract powder, honeysuckle detoxification capsules and preparation method thereof
  • Honeysuckle extraction method, honeysuckle dry extract powder, honeysuckle detoxification capsules and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] A method for extracting honeysuckle, characterized in that: comprising the steps of:

[0048] (1) One-time decoction: adding honeysuckle to water 10 times the weight of the honeysuckle to obtain a primary immersion liquid, vacuumize the primary immersion liquid, heat to 70°C to boil the primary immersion liquid, keep warm for 2 hours, then filter, Obtain primary filtrate and filter residue;

[0049] (2) Secondary decoction: add the filter residue obtained in step (1) to water that is 8 times the weight of the filter residue to obtain a secondary immersion liquid, vacuumize the secondary immersion liquid, and heat it to 70°C to make the secondary immersion liquid The liquid boils, and after being kept warm for 2 hours, it is filtered to obtain the secondary filtrate;

[0050] (3) concentration under reduced pressure: after combining the primary filtrate obtained in step (1) and the secondary filtrate obtained by step (2), carry out concentration under reduced pressure t...

Embodiment 2

[0056] A method for extracting honeysuckle, characterized in that: comprising the steps of:

[0057] (1) One-time decoction: add honeysuckle flower to the water of 8 times the weight of the honeysuckle flower to obtain a primary immersion liquid, vacuumize the primary immersion liquid, heat to 60° C. to boil the primary immersion liquid, and filter after keeping the temperature for 1 hour. Obtain primary filtrate and filter residue;

[0058] (2) Secondary decoction: add the filter residue obtained in step (1) to water that is 7 times the weight of the filter residue to obtain a secondary immersion liquid, vacuumize the secondary immersion liquid, and heat it to 60°C to make the secondary immersion liquid The liquid boils, and after being kept warm for 1h, it is filtered to obtain the secondary filtrate;

[0059] (3) concentration under reduced pressure: after combining the primary filtrate obtained in step (1) and the secondary filtrate obtained by step (2), carry out concent...

Embodiment 3

[0065] A method for extracting honeysuckle, characterized in that: comprising the steps of:

[0066] (1) One-time decoction: adding honeysuckle to water 12 times the weight of the honeysuckle to obtain a primary immersion liquid, vacuumize the primary immersion liquid, heat to 80° C. to boil the primary immersion liquid, keep warm for 3 hours, and then filter. Obtain primary filtrate and filter residue;

[0067] (2) Secondary decoction: add the filter residue obtained in step (1) to water 9 times the weight of the filter residue to obtain a secondary immersion liquid, vacuumize the secondary immersion liquid, and heat it to 80°C to make the secondary immersion liquid The liquid boils, and after being kept warm for 3 hours, it is filtered to obtain the secondary filtrate;

[0068] (3) concentration under reduced pressure: after combining the primary filtrate obtained in step (1) and the secondary filtrate obtained by step (2), carry out concentration under reduced pressure to ...

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Abstract

The invention relates to the technical field of Chinese herbal medicines, in particular to a honeysuckle extraction method, honeysuckle dry extract powder, honeysuckle detoxification capsules and a preparation method thereof. The honeysuckle extraction method comprises the following steps: (1) first decoction; (2) second decoction; (3) decompression and concentration; (4) vacuum drying. Accordingto the invention, a new vacuum dynamic low-temperature extraction method is adopted to ensure complete extraction of antibacterial active ingredients, improve the curative effect of medicines and theutilization rate of medicinal materials, the influencing factors are investigated to optimize experiments, the finally extracted honeysuckle dry extract powder has a high chlorogenic acid content, andthe extraction method is simple, effective, and easy to popularize. In addition, the invention further provides detoxification capsules taking the honeysuckle dry extract powder as a monarch drug, and the detoxification capsules have reasonable compatibility in a whole formula, have a high curative effect on clearing away heat and toxic materials and treating cold, and have a mild medicinal property and are easy to be absorbed by human bodies.

Description

technical field [0001] The invention relates to the technical field of Chinese herbal medicines, in particular to a method for extracting honeysuckle, dried honeysuckle paste powder, honeysuckle detoxifying capsules and a preparation method. Background technique [0002] Honeysuckle is also known as double flower and silver flower. It is the dried flower bud of Lonicerae. It is a commonly used traditional Chinese medicine for clearing away heat and detoxifying, cooling wind and heat. Its main active ingredient is chlorogenic acid. Chlorogenic acid has a long history of medicinal use and has antibacterial and antiviral properties. , the effect of protecting the liver and gallbladder, etc., the active ingredients of honeysuckle have been extracted all the time. In the past, the extraction methods of chlorogenic acid include water extraction of lime milk, water extraction, water extraction and alcohol precipitation, dilute alcohol extraction and other common methods. The conten...

Claims

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Application Information

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IPC IPC(8): A61K36/355A61K36/84A61K9/14A61K9/48A61P29/00A61P39/02A61P31/12A61K133/00
CPCA61K9/14A61K9/48A61K36/19A61K36/232A61K36/238A61K36/287A61K36/324A61K36/328A61K36/355A61K36/484A61K36/634A61K36/84A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 高东翔姜学勇周亚林施雪肖
Owner 广东广发制药有限公司
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