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A kind of toluidine blue high-efficiency photodynamic bactericidal composition and its application

A technology of toluidine blue and composition, applied in the field of medicine and health, can solve the problems of unsatisfactory long-term stability of products, decrease in sterilization effect, influence on application effect, etc., and achieve the effects of convenient storage and application and good stability

Active Publication Date: 2020-03-27
北京德得创业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gel provided by this solution is sensitive to the wavelength range of light when used, and the change of wavelength will lead to a significant decrease in its bactericidal effect, thereby affecting its application effect; at the same time, the long-term stability of the product provided by this solution is not ideal.

Method used

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  • A kind of toluidine blue high-efficiency photodynamic bactericidal composition and its application
  • A kind of toluidine blue high-efficiency photodynamic bactericidal composition and its application
  • A kind of toluidine blue high-efficiency photodynamic bactericidal composition and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0017] This example provides a high-efficiency photodynamic bactericidal composition, which is a gel, prepared by the following method: take 100 mL of phosphate buffer solution with a pH value of 7.5, first add 0.1 g of toluidine blue to configure a concentration of 0.001 g / ml solution, add 0.01g methylene blue after fully dispersed, add 0.05g sodium hyaluronate after fully dispersed to form a gel state.

Embodiment 2

[0019] This embodiment provides a high-efficiency photodynamic bactericidal composition, which is a gel, prepared by the following method: take 100 mL of phosphate buffer solution with a pH value of 8.0, first add 0.5 g of toluidine blue to configure a concentration of 0.005 g / ml solution, add 0.05g methylene blue after fully dispersed, add 0.1g sodium hyaluronate after fully dispersed to form a gel state.

Embodiment 3

[0021] This embodiment provides a high-efficiency photodynamic bactericidal composition, which is a gel, prepared by the following method: take 100 mL of phosphate buffer solution with a pH value of 7.0, first add 0.01 g of toluidine blue to configure a concentration of 0.0001 g / ml solution, add 0.01g methylene blue after fully dispersed, add 1g sodium hyaluronate after fully dispersed to form a gel state.

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Abstract

The invention relates to a toluidine blue efficient photodynamic bactericidal composition, which comprises toluidine blue and methylene blue in a mass ratio of 1:0.03-30. The composition provided by the invention uses the synergistic effect of toluidine blue and methylene blue, has a bactericidal effect superior to a toluidine blue single component under the same condition, also the product is notsensitive to the light wavelength range change, and the wavelength change does not affect the bactericidal effect, therefore wavelength range change does not cause a reduced bactericidal effect during application of the composition. At the same time, the composition provided by the invention has good stability, and is convenient for storage and application.

Description

technical field [0001] The invention relates to the field of medicine and hygiene, in particular to a toluidine blue high-efficiency photodynamic bactericidal composition and a preparation method thereof. Background technique [0002] Photodynamic therapy is a non / minimally invasive treatment method that uses the optical properties of substances to generate reactive oxygen species (ROS) by combining photosensitizers with light waves of a certain wavelength to kill bacteria. This method is widely used in various fields such as comprehensive treatment of various cancers, skin disease treatment, oral disease control and treatment, etc. This method has quick results, is effective against a large number of bacteria, has no immune response, has no side effects, and can be used repeatedly The advantages. Toluidine blue gel is a photosensitizer gel, which has the following advantages: The gel preparation has certain viscosity and adhesion, which can make the drug stay in the diseas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P31/04A61P17/02A61P31/02
CPCA61K41/0057A61K2300/00
Inventor 常丽李次会王宏
Owner 北京德得创业科技有限公司