Radix salviae miltiorrhizae gel patch for external use
A technology of gel patch and Salvia miltiorrhiza, applied in the directions of anti-inflammatory agents, non-central analgesics, medical preparations with inactive ingredients, etc., can solve the problems of poor drug release permeability and insignificant effect, and achieve drug release The effect of rate increase
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Embodiment 1
[0021] A kind of Danshen gel patch for external use, comprising medical non-woven fabric, gel layer, antisticking layer, described gel layer is Danshen gel, and the formula component of described Danshen gel is: Tanshinone 0.8- 1.2%, carbomer 18-22%, hydroxypropyl methylcellulose 45-50%, polyvinylpyrrolidone 15-20%, cross-linking agent 2-5%, surfactant 1-3%, co-surfactant Agent 0.8-1.5%, moisturizing agent 0.5-0.8%, the preparation of Danshen gel comprises the following steps:
[0022] S1. Add 18% carbomer in the glass container by weight, add distilled water with a material-to-liquid weight ratio of 3:97, configure 3% carbomer hydrogel, and adjust the pH value to 5 with triethanolamine;
[0023] S2. In another glass container, add 45% hydroxypropyl methylcellulose by weight, add distilled water at a material-to-liquid weight ratio of 5:95, and configure 5% hydroxypropylmethylcellulose hydrogel ;
[0024] S3. Mix the configured 3% carbomer hydrogel with 5% hydroxypropyl meth...
Embodiment 2
[0033] The preparation of Danshen gel comprises the following steps:
[0034] S1. Add 20% carbomer in the glass container by weight, add distilled water at a weight ratio of 3:97 to liquid, configure 3% carbomer hydrogel, and adjust the pH value to 5 with triethanolamine;
[0035] S2. In another glass container, add 47% hydroxypropyl methylcellulose by weight, add distilled water at a weight ratio of 5:95, and configure 5% hydroxypropylmethylcellulose hydrogel ;
[0036] S3. Mix the configured 3% carbomer hydrogel with 5% hydroxypropyl methylcellulose hydrogel, stir, and after centrifugation, add 1.2% tanshinone and 18% polyvinyl alcohol in sequence. Vinylpyrrolidone, 5% cross-linking agent, 2% surfactant, 1.2% co-surfactant, 0.5% moisturizing agent, ultrasonic treatment is used to mix all components evenly to obtain drug-containing gel;
[0037] S4. Steam sterilize the obtained drug-containing gel at a pressure of 105kPa and a temperature of 120-150°C for 45 minutes to obta...
Embodiment 3
[0043] The preparation of Danshen gel comprises the following steps:
[0044] S1. Add 22% carbomer in the glass container by weight, add distilled water at a weight ratio of 3:97 to liquid, configure 3% carbomer hydrogel, and adjust the pH value to 5 with triethanolamine;
[0045] S2. In another glass container, add 50% hydroxypropyl methylcellulose by weight, add distilled water at a material-to-liquid weight ratio of 5:95, and configure 5% hydroxypropylmethylcellulose hydrogel ;
[0046] S3. Mix the configured 3% carbomer hydrogel with 5% hydroxypropyl methylcellulose hydrogel, stir, and after centrifugation, add 1.2% tanshinone and 20% polyvinyl alcohol in sequence. Vinylpyrrolidone, 4.5% cross-linking agent, 3% surfactant, 1.5% co-surfactant, 0.8% moisturizing agent, ultrasonic treatment is used to mix all components evenly to obtain drug-containing gel;
[0047] S4, steam sterilize the obtained drug-containing gel at a pressure of 105kPa and a temperature of 120-150°C f...
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