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Radix salviae miltiorrhizae gel patch for external use

A technology of gel patch and Salvia miltiorrhiza, applied in the directions of anti-inflammatory agents, non-central analgesics, medical preparations with inactive ingredients, etc., can solve the problems of poor drug release permeability and insignificant effect, and achieve drug release The effect of rate increase

Inactive Publication Date: 2018-05-29
ANHUI AIKEER PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally, it is administered orally or by injection. There are few Danshen gel patches on the market that are used as patches for external use, have good contact with the skin, are non-irritating to the skin, and can control the drug release rate. Poor sex, resulting in insignificant effect

Method used

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  • Radix salviae miltiorrhizae gel patch for external use

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of Danshen gel patch for external use, comprising medical non-woven fabric, gel layer, antisticking layer, described gel layer is Danshen gel, and the formula component of described Danshen gel is: Tanshinone 0.8- 1.2%, carbomer 18-22%, hydroxypropyl methylcellulose 45-50%, polyvinylpyrrolidone 15-20%, cross-linking agent 2-5%, surfactant 1-3%, co-surfactant Agent 0.8-1.5%, moisturizing agent 0.5-0.8%, the preparation of Danshen gel comprises the following steps:

[0022] S1. Add 18% carbomer in the glass container by weight, add distilled water with a material-to-liquid weight ratio of 3:97, configure 3% carbomer hydrogel, and adjust the pH value to 5 with triethanolamine;

[0023] S2. In another glass container, add 45% hydroxypropyl methylcellulose by weight, add distilled water at a material-to-liquid weight ratio of 5:95, and configure 5% hydroxypropylmethylcellulose hydrogel ;

[0024] S3. Mix the configured 3% carbomer hydrogel with 5% hydroxypropyl meth...

Embodiment 2

[0033] The preparation of Danshen gel comprises the following steps:

[0034] S1. Add 20% carbomer in the glass container by weight, add distilled water at a weight ratio of 3:97 to liquid, configure 3% carbomer hydrogel, and adjust the pH value to 5 with triethanolamine;

[0035] S2. In another glass container, add 47% hydroxypropyl methylcellulose by weight, add distilled water at a weight ratio of 5:95, and configure 5% hydroxypropylmethylcellulose hydrogel ;

[0036] S3. Mix the configured 3% carbomer hydrogel with 5% hydroxypropyl methylcellulose hydrogel, stir, and after centrifugation, add 1.2% tanshinone and 18% polyvinyl alcohol in sequence. Vinylpyrrolidone, 5% cross-linking agent, 2% surfactant, 1.2% co-surfactant, 0.5% moisturizing agent, ultrasonic treatment is used to mix all components evenly to obtain drug-containing gel;

[0037] S4. Steam sterilize the obtained drug-containing gel at a pressure of 105kPa and a temperature of 120-150°C for 45 minutes to obta...

Embodiment 3

[0043] The preparation of Danshen gel comprises the following steps:

[0044] S1. Add 22% carbomer in the glass container by weight, add distilled water at a weight ratio of 3:97 to liquid, configure 3% carbomer hydrogel, and adjust the pH value to 5 with triethanolamine;

[0045] S2. In another glass container, add 50% hydroxypropyl methylcellulose by weight, add distilled water at a material-to-liquid weight ratio of 5:95, and configure 5% hydroxypropylmethylcellulose hydrogel ;

[0046] S3. Mix the configured 3% carbomer hydrogel with 5% hydroxypropyl methylcellulose hydrogel, stir, and after centrifugation, add 1.2% tanshinone and 20% polyvinyl alcohol in sequence. Vinylpyrrolidone, 4.5% cross-linking agent, 3% surfactant, 1.5% co-surfactant, 0.8% moisturizing agent, ultrasonic treatment is used to mix all components evenly to obtain drug-containing gel;

[0047] S4, steam sterilize the obtained drug-containing gel at a pressure of 105kPa and a temperature of 120-150°C f...

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Abstract

The invention discloses a radix salviae miltiorrhizae gel patch for external use. The radix salviae miltiorrhizae gel patch comprises medical nonwoven fabric, a gel layer and an anti-sticking layer, wherein the gel layer is radix salviae miltiorrhizae gel, and the radix salviae miltiorrhizae gel is prepared from the following formula components by weight percent: 0.8-1.2% of tanshinone, 18-22% ofcarbomer, 45-50% of hydroxypropyl methyl cellulose, 15-20% of polyvinylpyrrolidone, 2-5% of a cross-linking agent, 1-3% of a surface active agent, 0.8-1.5% of a cosurfactant and 0.5-0.8% of a humidifying agent. According to the radix salviae miltiorrhizae gel patch, the carbomer is used as a gel substrate, the hydroxypropyl methyl cellulose and the polyvinylpyrrolidone which are taken as a penetration enhancer, the cross-linking agent and the surface active agent are added, and all the components are evenly mixed by adopting ultrasonic treatment, so that the drug release rate is increased; furthermore, the radix salviae miltiorrhizae gel patch for external use is free from irritation to skin.

Description

technical field [0001] The invention relates to the field of gel preparations, in particular to a Danshen gel patch for external use. Background technique [0002] Tanshinone is a fat-soluble active ingredient of Danshen containing a variety of conjugated quinones and ketones. It has antibacterial, anti-inflammatory, blood-activating and stasis-removing effects, and can treat various bacterial infections and cardiovascular and cerebrovascular diseases. Generally, it is administered orally or by injection. There are few Danshen gel patches on the market that are used as patches for external use, have good contact with the skin, are non-irritating to the skin, and can control the drug release rate. Poor performance, resulting in insignificant effect. Contents of the invention [0003] The object of the present invention is to provide a kind of Danshen gel patch for external use, to solve the problems raised in the above-mentioned background technology. [0004] To achi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/38A61K31/58A61P29/00A61P31/04
CPCA61K9/7061A61K31/58A61K47/32A61K47/38
Inventor 王殿阔
Owner ANHUI AIKEER PHARMA CO LTD
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