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Novel application of 4-hydroxyisoleucine

A hydroxyisoleucine and drug technology, applied in the field of drug application, can solve the problems of lack of reliable clinical trial research and no curative treatment drugs

Inactive Publication Date: 2018-05-29
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the complex and diverse characteristics of the pathogenesis of NAFLD, the current research on the mechanism is mostly limited to cell and animal experiments, and there is still a lack of reliable clinical trial research, so there is currently no therapeutic drug with significant curative effect

Method used

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  • Novel application of 4-hydroxyisoleucine
  • Novel application of 4-hydroxyisoleucine
  • Novel application of 4-hydroxyisoleucine

Examples

Experimental program
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Embodiment Construction

[0021] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0022] Application test.

[0023] Experimental program.

[0024] Materials and Instruments

[0025] .

[0026] experimental animals.

[0027] C57BL / 6 mice, male, SPF grade, 4 weeks old, were purchased from Beijing Weitong Lihua Biotechnology Co., Ltd.

[0028] The experimental animals were raised aseptically, the feeding temperature: 23±2°C, the humidity: (55±10)%, 12 / 12h day and night cycle, free to eat and drink. The cages, feed, litter and drinking water used were all sterilized by autoclaving, and the breeding environment met the requirements for the environmental facilities of medical experimental animals.

[0029] Animal food.

[0030] 60% high-fat purified feed was purchased from Beijing Huafukang Biotechnology Co., Ltd., and the main energy content is shown...

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Abstract

The invention relates to an application of 4-hydroxyisoleucine in preparation of weight losing drugs or non-alcoholic fatty liver disease protecting drugs or healthcare food, that is, an application of the 4-hydroxyisoleucine in preparation of drugs for treating obesity and non-alcoholic fatty liver diseases. Oral preparations, capsules, tablets, granules and the like can be produced. Experiment find that 4-hydroxyisoleucine can effectively reduce weight, gathering of fat in the body, content of total cholesterol, triglyceride and low density lipoprotein in plasma and glutamic oxalacetic transaminase, protect the liver function, relieve fatty liver, reduce accumulation of liver lipid and safely and effectively reduce weight, reduce lipid and protect the liver for groups requiring obesity treatment.

Description

technical field [0001] The invention belongs to the technical field of drug application, and specifically relates to the new medical application of 4-hydroxyisoleucine, especially the application of 4-hydroxyisoleucine in preparing weight-loss drugs or non-alcoholic fatty liver protection drugs. Background technique [0002] Today's social and economic development has changed people's way of life and brought a lot of convenience to people. At the same time, the number of obese people in the world has increased sharply, and the adverse effects of obesity on health have been highlighted. Obesity is a chronic metabolic disease caused by multiple factors and is a major risk factor for type Ⅱ diabetes, cardiovascular disease and certain cancers. At least 2.8 million deaths worldwide each year can be attributed to being overweight or obese. Obesity is characterized by an increase in the volume and number of fat cells in the body, an abnormally high percentage of body fat to body...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P1/16A61P3/04A61P3/06A23L33/175
Inventor 李国栋杨佳丽宋舒怡祁元明高艳锋
Owner ZHENGZHOU UNIV
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