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Extraction method of high-purity andrographolide

A technology of andrographolide and extraction method, applied in the direction of organic chemistry, etc., can solve the problems of large amount of organic solvent usage, low yield of andrographolide, high extraction cost, etc., achieve less extraction solvent, shorten production cycle, and short extraction time Effect

Active Publication Date: 2018-05-29
BEIHAI KAIYUAN BIOLOGICAL TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purpose of the present invention is to provide a method for extracting andrographolide, which uses dynamic countercurrent extraction technology to extract andrographolide, effectively solving the problems of low yield of andrographolide, large amount of organic solvent used, high extraction cost, and poor safety.

Method used

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  • Extraction method of high-purity andrographolide
  • Extraction method of high-purity andrographolide
  • Extraction method of high-purity andrographolide

Examples

Experimental program
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Effect test

Embodiment 1

[0035] (1) Pulverization: take 100Kg of Andrographis paniculata, and pulverize it to an average length of 3 cm.

[0036] (2) Extraction: Inject 500L of 95% ethanol into the extraction cylinder. When the liquid level of the solvent reaches 3 / 4 of the diameter of the cylinder, open the steam valve to heat the solvent. When the temperature reaches 60°C, start to put Andrographis paniculata in the extraction cylinder. Grass powder, control the rotation speed of the shaft of the extraction cylinder to 3r / min, and the spiral belt fixed on the shaft slowly pushes the Andrographis paniculata powder from the front of the unit to the rear, and at the same time, the extraction solvent enters the filter from the liquid inlet at the end of the unit, and is discharged from the back of the cylinder. The end passes through the moving material and flows to the front end. The solid-liquid two-phase material is fully contacted in this reverse movement. When the Andrographis paniculata powder is c...

Embodiment 2

[0044] (1) Pulverization: take 100Kg of Andrographis paniculata, and pulverize it to an average length of 2 cm.

[0045] (2) Extraction: Inject 500L of 95% methanol into the extraction cylinder. When the liquid level of the solvent reaches 3 / 4 of the diameter of the cylinder, open the steam valve to heat the solvent. When the temperature reaches 60°C, start to put Andrographis paniculata into the extraction cylinder. Grass powder, control the rotation speed of the shaft of the extraction cylinder to 3r / min, and the spiral belt fixed on the shaft slowly pushes the Andrographis paniculata powder from the front of the unit to the rear, and at the same time, the extraction solvent enters the filter from the liquid inlet at the end of the unit, and is discharged from the back of the cylinder. The end passes through the moving material and flows to the front end. The solid-liquid two-phase material is fully contacted in this reverse movement. When the Andrographis paniculata powder i...

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Abstract

The invention discloses an extraction method of high-purity andrographolidume. After herba andrographis paniculatae powder is crushed, a dynamic reverse flow extraction method is used for extracting the andrographolide; the andrographolide is obtained through activated carbon chromatography column decoloring, recrystallization and drying. The yield of the andrographolide is 82.9 percent or higher;the purity is 99.6 percent or higher; the solvent consumption is low; the product purity is high; the impurity content is low; the method is suitable for being used for synthesizing potassium dehydroandrographolide succinate and potassium sodium dehydroandroan drographolide succinate; the relevant substance content of synthetics is very low.

Description

technical field [0001] The invention relates to the field of extraction of traditional Chinese medicines, in particular to a method for extracting high-purity andrographolide based on the principle of dynamic countercurrent extraction technology. Background technique [0002] Andrographis paniculata Nees is a perennial or annual herb of the family Andrographis paniculata Nees. It is also known as Yijianxi, Zhanshejian, Zhantongjian, bitter grass, bitter gall grass, square grass, Larvae, and cone herb. The whole plant is used as medicine. Andrographis paniculata is bitter in taste and cold in nature, and it is a commonly used traditional Chinese medicine, and it is one of the first-selected antiviral drugs. [0003] Andrographolide is a diterpene lactone compound extracted from Andrographis paniculata. It is one of the main active ingredients of the traditional Chinese medicine Andrographis paniculata. The molecular formula is C 20 h 30 o 5 , white prismatic or flaky cryst...

Claims

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Application Information

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IPC IPC(8): C07D307/60
CPCC07D307/60
Inventor 石清东莫丽影
Owner BEIHAI KAIYUAN BIOLOGICAL TECH